Mechanism of improved antibody aggregate separation in polyethylene glycol-modulated cation exchange chromatography
Kluters, Simon, Neumann, Sebastian, von Hirschheydt, Thomas, Grossmann, Adelbert, Schaubmar, Andreas, Frech, Christian
Published in Journal of separation science (01.11.2012)
Published in Journal of separation science (01.11.2012)
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Journal Article
Modeling of bispecific antibody elution in mixed‐mode cation‐exchange chromatography
Lee, Yi Feng, Kluters, Simon, Hillmann, Mirjam, Hirschheydt, Thomas, Frech, Christian
Published in Journal of separation science (01.09.2017)
Published in Journal of separation science (01.09.2017)
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Journal Article
End-to-end approach for the characterization and control of product-related impurities in T cell bispecific antibody preparations
Larivière, Laurent, Krüger, Julia Eva, von Hirschheydt, Thomas, Schlothauer, Tilman, Bray-French, Katharine, Bader, Martin, Runza, Valeria
Published in International journal of pharmaceutics: X (01.12.2023)
Published in International journal of pharmaceutics: X (01.12.2023)
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Journal Article
Anti-Langmuir elution behavior of a bispecific monoclonal antibody in cation exchange chromatography: Mechanistic modeling using a pH-dependent Self-Association Steric Mass Action isotherm
Seelinger, Felix, Wittkopp, Felix, von Hirschheydt, Thomas, Frech, Christian
Published in Journal of Chromatography A (25.01.2023)
Published in Journal of Chromatography A (25.01.2023)
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Journal Article
Application of the Steric Mass Action formalism for modeling under high loading conditions: Part 2. Investigation of high loading and column overloading effects
Seelinger, Felix, Wittkopp, Felix, von Hirschheydt, Thomas, Frech, Christian
Published in Journal of Chromatography A (02.08.2022)
Published in Journal of Chromatography A (02.08.2022)
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Journal Article
Application of the Steric Mass Action formalism for modeling under high loading conditions: Part 1. Investigation of the influence of pH on the steric shielding factor
Seelinger, Felix, Wittkopp, Felix, von Hirschheydt, Thomas, Hafner, Mathias, Frech, Christian
Published in Journal of Chromatography A (02.08.2022)
Published in Journal of Chromatography A (02.08.2022)
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Journal Article
A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors
Bacac, Marina, Fauti, Tanja, Sam, Johannes, Colombetti, Sara, Weinzierl, Tina, Ouaret, Djamila, Bodmer, Walter, Lehmann, Steffi, Hofer, Thomas, Hosse, Ralf J, Moessner, Ekkehard, Ast, Oliver, Bruenker, Peter, Grau-Richards, Sandra, Schaller, Teilo, Seidl, Annette, Gerdes, Christian, Perro, Mario, Nicolini, Valeria, Steinhoff, Nathalie, Dudal, Sherri, Neumann, Sebastian, von Hirschheydt, Thomas, Jaeger, Christiane, Saro, Jose, Karanikas, Vaios, Klein, Christian, Umaña, Pablo
Published in Clinical cancer research (01.07.2016)
Published in Clinical cancer research (01.07.2016)
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Journal Article
Solvent modulation strategy for superior antibody monomer/aggregate separation in cation exchange chromatography
Kluters, Simon, Frech, Christian, von Hirschheydt, Thomas, Schaubmar, Andreas, Neumann, Sebastian
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.12.2015)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.12.2015)
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Journal Article
Abstract 2508: GE-huMab-HER3, a novel humanized, glycoengineered HER3 antibody with enhanced ADCC and superior preclinical in vitro and in vivo efficacy
Bossenmaier, Birgit, Friess, Thomas, Gerdes, Christian, Kolm, Irene, Dimoudis, Nikolaos, Lifke, Valeria, Reiff, Ulrike, Moessner, Ekkehard, Hoelzlwimmer, Gabriele, von Hirschheydt, Thomas, Burtscher, Helmut, Niederfellner, Gerhard
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Journal Article
Mechanism of improved antibody aggregate separation in polyethylene glycol-modulated cation exchange chromatography: Biotechnology
KLUTERS, Simon, NEUMANN, Sebastian, VON HIRSCHHEYDT, Thomas, GROSSMANN, Adelbert, SCHAUBMAR, Andreas, FRECH, Christian
Published in Journal of separation science (2012)
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Published in Journal of separation science (2012)
Journal Article
Depletion of light chain mispaired antibody variants by hydrophobic interaction chromatography
Hertenberger, Hubert, Rueger, Petra, Weydanz, Birgit, Von Hirschheydt, Thomas
Year of Publication 02.04.2024
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Year of Publication 02.04.2024
Patent
Depletion of Light Chain Mispaired Antibody Variants By Hydrophobic Interaction Chromatography
Hertenberger, Hubert, Rueger, Petra, Weydanz, Birgit, Von Hirschheydt, Thomas
Year of Publication 26.11.2020
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Year of Publication 26.11.2020
Patent
DEPLETION OF LIGHT CHAIN MISPAIRED ANTIBODY VARIANTS BY HYDROPHOBIC INTERACTION CHROMATOGRAPHY
HERTENBERGER, Hubert, WEYDANZ, Birgit, RUEGER, Petra, VON HIRSCHHEYDT, Thomas
Year of Publication 28.10.2020
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Year of Publication 28.10.2020
Patent
DEPLETION OF LIGHT CHAIN MISPAIRED ANTIBODY VARIANTS BY HYDROPHOBIC INTERACTION CHROMATOGRAPHY
HERTENBERGER, Hubert, WEYDANZ, Birgit, RUEGER, Petra, VON HIRSCHHEYDT, Thomas
Year of Publication 27.06.2019
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Year of Publication 27.06.2019
Patent