The Cytosolic Entry of Diphtheria Toxin Catalytic Domain Requires a Host Cell Cytosolic Translocation Factor Complex
Ratts, Ryan, Zeng, Huiyan, Berg, Eric A., Blue, Clare, McComb, Mark E., Costello, Cathy E., vanderSpek, Johanna C., Murphy, John R.
Published in The Journal of cell biology (31.03.2003)
Published in The Journal of cell biology (31.03.2003)
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Genetic and Biophysical Studies of Diphtheria Toxin Repressor (DtxR) and the Hyperactive Mutant DtxR(E175K) Support a Multistep Model of Activation
Love, John F., vanderSpek, Johanna C., Marin, Vedrana, Guerrero, Luis, Logan, Timothy M., Murphy, John R., Mekalanos, John J.
Published in Proceedings of the National Academy of Sciences - PNAS (24.02.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (24.02.2004)
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Journal Article
Structure of the metal-ion-activated diphtheria toxin repressor/ tox operator complex
Ringe, Dagmar, White, André, Ding, Xiaochun, vanderSpek, Johanna C, Murphy, John R
Published in Nature (London) (30.07.1998)
Published in Nature (London) (30.07.1998)
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Journal Article
Mn(II) Binding by the Anthracis Repressor from Bacillus anthracis
Sen, K. Ilker, Sienkiewicz, Andrzej, Love, John F, vanderSpek, Johanna C, Fajer, Piotr G, Logan, Timothy M
Published in Biochemistry (Easton) (04.04.2006)
Published in Biochemistry (Easton) (04.04.2006)
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A survival motor neuron:tetanus toxin fragment C fusion protein for the targeted delivery of SMN protein to neurons
Francis, Jonathan W., Figueiredo, Dayse, vanderSpek, Johanna C., Ayala, Laura M., Kim, Young Seon, Remington, Mary P., Young, Philip J., Lorson, Christian L., Ikebe, Shinichiro, Fishman, Paul S., Brown, Robert H.
Published in Brain research (02.01.2004)
Published in Brain research (02.01.2004)
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Characterization and receptor specific toxicity of two diphtheria toxin‐related interleukin‐3 fusion proteins DAB389–mIL‐3 and DAB389–(Gly4Ser)2‐mIL‐3
Liger, Dominique, vanderSpek, Johanna C, Gaillard, Carole, Cansier, Christophe, Murphy, John R, Leboulch, Philippe, Gillet, Daniel
Published in FEBS letters (07.04.1997)
Published in FEBS letters (07.04.1997)
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Inhibition of protein synthesis in small cell lung cancer cells induced by the diphtheria toxin-related fusion protein DAB389 GRP
VANDERSPEK, J. C, SUTHERLAND, J. A, ZENG, H, BATTEY, J. F, JENSEN, R. T, MURPHY, J. R
Published in Cancer research (Chicago, Ill.) (15.01.1997)
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Published in Cancer research (Chicago, Ill.) (15.01.1997)
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Enhancement of diphtheria toxin potency by replacement of the receptor binding domain with tetanus toxin C-fragment : A potential vector for delivering heterologous proteins to neurons
FRANCIS, J. W, BROWN, R. H, FIGUEIREDO, D, REMINGTON, T. P, CASTILLO, O, SCHWARZSCHILD, M. A, FISHMAN, P. S, MURPHY, J. R, VANDERSPEK, J. C
Published in Journal of neurochemistry (01.06.2000)
Published in Journal of neurochemistry (01.06.2000)
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Journal Article
Enhancement of Diphtheria Toxin Potency by Replacement of the Receptor Binding Domain with Tetanus Toxin C‐Fragment
Francis, Jonathan W., Brown, Robert H., Figueiredo, Dayse, Remington, Mary P., Castillo, Orlando, Schwarzschild, Michael A., Fishman, Paul S., Murphy, John R., VanderSpek, Johanna C.
Published in Journal of neurochemistry (01.06.2000)
Published in Journal of neurochemistry (01.06.2000)
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Structure/function analysis of the transmembrane domain of DAB389-interleukin-2, an interleukin-2 receptor-targeted fusion toxin. The amphipathic helical region of the transmembrane domain is essential for the efficient delivery of the catalytic domain to the cytosol of target cells
VANDERSPEK, J. C, MINDELL, J. A, FINKELSTEIN, A, MURPHY, J. R
Published in The Journal of biological chemistry (05.06.1993)
Published in The Journal of biological chemistry (05.06.1993)
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Journal Article
Characterization and receptor specific toxicity of two diphtheria toxin-related interleukin-3 fusion proteins DAB 389–mIL-3 and DAB 389–(Gly 4Ser) 2-mIL-3
Liger, Dominique, vanderSpek, Johanna C, Gaillard, Carole, Cansier, Christophe, Murphy, John R, Leboulch, Philippe, Gillet, Daniel
Published in FEBS letters (07.04.1997)
Published in FEBS letters (07.04.1997)
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Journal Article
Genetic Construction and Properties of a Diphtheria Toxin-Related Substance P Fusion Protein: In vitro Destruction of Cells Bearing Substance P Receptors
Fisher, Caroline E., Sutherland, Jay A., Krause, James E., Murphy, John R., Leeman, Susan E., VanderSpek, Johanna C.
Published in Proceedings of the National Academy of Sciences - PNAS (09.07.1996)
Published in Proceedings of the National Academy of Sciences - PNAS (09.07.1996)
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