Radiosynthesis and biodistribution of a histamine H3 receptor antagonist 4-[3-(4-piperidin-1-yl-but-1-ynyl)-[11C]benzyl]-morpholine: evaluation of a potential PET ligand
Airaksinen, Anu J, Jablonowski, Jill A, van der Mey, Margreet, Barbier, Ann J, Klok, Rob P, Verbeek, Joost, Schuit, Robert, Herscheid, Jacobus D M, Leysen, Josee E, Carruthers, Nicholas I, Lammertsma, Adriaan A, Windhorst, Albert D
Published in Nuclear medicine and biology (01.08.2006)
Published in Nuclear medicine and biology (01.08.2006)
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Journal Article
Radiosynthesis and biodistribution of a histamine H 3 receptor antagonist 4-[3-(4-piperidin-1-yl-but-1-ynyl)-[ 11C]benzyl]-morpholine: evaluation of a potential PET ligand
Airaksinen, Anu J., Jablonowski, Jill A., van der Mey, Margreet, Barbier, Ann J., Klok, Rob P., Verbeek, Joost, Schuit, Robert, Herscheid, Jacobus D.M., Leysen, Josee E., Carruthers, Nicholas I., Lammertsma, Adriaan A., Windhorst, Albert D.
Published in Nuclear medicine and biology (01.08.2006)
Published in Nuclear medicine and biology (01.08.2006)
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Journal Article
Substrate specificity of immobilized penicillin-G acylase towards penicillin and cephalosporin derivatives was studied. The phenylacetyl moiety can be altered at the α-position with several small substituents. Depending on polarity and size of the substituent, enzyme activity decreases or increases. Insertion or deletion of atoms between the aromatic nucleus of the phenylacetyl group and the center of hydrolysis leads to substrates that are no longer recognized by the enzyme
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