Tumor suppressors BTG1 and BTG2: Beyond growth control
Yuniati, Laurensia, Scheijen, Blanca, Meer, Laurens T., Leeuwen, Frank N.
Published in Journal of cellular physiology (01.05.2019)
Published in Journal of cellular physiology (01.05.2019)
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Journal Article
Amino Acid Depletion Therapies: Starving Cancer Cells to Death
Butler, Miriam, van der Meer, Laurens T., van Leeuwen, Frank N.
Published in Trends in endocrinology and metabolism (01.06.2021)
Published in Trends in endocrinology and metabolism (01.06.2021)
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Journal Article
The origin and nature of tightly clustered BTG1 deletions in precursor B-cell acute lymphoblastic leukemia support a model of multiclonal evolution
Waanders, Esmé, Scheijen, Blanca, van der Meer, Laurens T, van Reijmersdal, Simon V, van Emst, Liesbeth, Kroeze, Yvet, Sonneveld, Edwin, Hoogerbrugge, Peter M, van Kessel, Ad Geurts, van Leeuwen, Frank N, Kuiper, Roland P
Published in PLoS genetics (01.02.2012)
Published in PLoS genetics (01.02.2012)
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Journal Article
Histone deacetylase inhibition sensitizes p53-deficient B-cell precursor acute lymphoblastic leukemia to chemotherapy
Cox, Willem P J, Evander, Nils, Van Ingen Schenau, Dorette S, Stoll, Gawin R, Anderson, Nadia, De Groot, Lieke, Grünewald, Kari J T, Hagelaar, Rico, Butler, Miriam, Kuiper, Roland P, Van der Meer, Laurens T, Van Leeuwen, Frank N
Published in Haematologica (Roma) (01.06.2024)
Published in Haematologica (Roma) (01.06.2024)
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Journal Article
Reversal of IKZF1-induced glucocorticoid resistance by dual targeting of AKT and ERK signaling pathways
Butler, Miriam, Vervoort, Britt M.T., van Ingen Schenau, Dorette S., Jongeneel, Lieneke, van der Zwet, Jordy C.G., Marke, René, Meijerink, Jules P.P., Scheijen, Blanca, van der Meer, Laurens T., van Leeuwen, Frank N.
Published in Frontiers in oncology (02.09.2022)
Published in Frontiers in oncology (02.09.2022)
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Journal Article
Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients
Scheijen, Blanca, Boer, Judith M, Marke, René, Tijchon, Esther, van Ingen Schenau, Dorette, Waanders, Esmé, van Emst, Liesbeth, van der Meer, Laurens T, Pieters, Rob, Escherich, Gabriele, Horstmann, Martin A, Sonneveld, Edwin, Venn, Nicola, Sutton, Rosemary, Dalla-Pozza, Luciano, Kuiper, Roland P, Hoogerbrugge, Peter M, den Boer, Monique L, van Leeuwen, Frank N
Published in Haematologica (Roma) (01.03.2017)
Published in Haematologica (Roma) (01.03.2017)
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Journal Article
Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1
Marteijn, Jurgen A.F., van der Meer, Laurens T., van Emst, Liesbeth, van Reijmersdal, Simon, Wissink, Willemijn, de Witte, Theo, Jansen, Joop H., Van der Reijden, Bert A.
Published in Blood (01.11.2007)
Published in Blood (01.11.2007)
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Journal Article
BTK inhibition sensitizes acute lymphoblastic leukemia to asparaginase by suppressing the amino acid response pathway
Butler, Miriam, van Ingen Schenau, Dorette S., Yu, Jiangyan, Jenni, Silvia, Dobay, Maria P., Hagelaar, Rico, Vervoort, Britt M.T., Tee, Trisha M., Hoff, Fieke W., Meijerink, Jules P., Kornblau, Steven M., Bornhauser, Beat, Bourquin, Jean-Pierre, Kuiper, Roland P., van der Meer, Laurens T., van Leeuwen, Frank N.
Published in Blood (09.12.2021)
Published in Blood (09.12.2021)
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Journal Article
IKZF1 gene deletions drive resistance to cytarabine in B-cell precursor acute lymphoblastic leukemia
Vervoort, Britt M T, Butler, Miriam, Grünewald, Kari J T, Schenau, Dorette S van Ingen, Tee, Trisha M, Lucas, Luc, Huitema, Alwin D R, Boer, Judith M, Bornhauser, Beat C, Bourquin, Jean-Pierre, Hoogerbrugge, Peter M, Van der Velden, Vincent H J, Kuiper, Roland P, Van der Meer, Laurens T, Van Leeuwen, Frank N
Published in Haematologica (Roma) (06.06.2024)
Published in Haematologica (Roma) (06.06.2024)
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Journal Article
Tumor suppressor BTG1 promotes PRMT1-mediated ATF4 function in response to cellular stress
Yuniati, Laurensia, van der Meer, Laurens T, Tijchon, Esther, van Ingen Schenau, Dorette, van Emst, Liesbeth, Levers, Marloes, Palit, Sander A L, Rodenbach, Caroline, Poelmans, Geert, Hoogerbrugge, Peter M, Shan, Jixiu, Kilberg, Michael S, Scheijen, Blanca, van Leeuwen, Frank N
Published in Oncotarget (19.01.2016)
Published in Oncotarget (19.01.2016)
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Journal Article
In Vivo Imaging of Antileukemic Drug Asparaginase Reveals a Rapid Macrophage-Mediated Clearance from the Bone Marrow
van der Meer, Laurens T, Terry, Samantha Y A, van Ingen Schenau, Dorette S, Andree, Kiki C, Franssen, Gerben M, Roeleveld, Debbie M, Metselaar, Josbert M, Reinheckel, Thomas, Hoogerbrugge, Peter M, Boerman, Otto C, van Leeuwen, Frank N
Published in Journal of Nuclear Medicine (01.02.2017)
Published in Journal of Nuclear Medicine (01.02.2017)
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Journal Article
Tumor suppressor BTG1 limits activation of BCL6 expression downstream of ETV6-RUNX1
Tijchon, Esther, van Emst, Liesbeth, Yuniati, Laurensia, van Ingen Schenau, Dorette, Gerritsen, Mylène, van der Meer, Laurens T., Williams, Owen, Hoogerbrugge, Peter M., Scheijen, Blanca, van Leeuwen, Frank N.
Published in Experimental hematology (01.04.2018)
Published in Experimental hematology (01.04.2018)
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Journal Article
A germ line mutation in cathepsin B points toward a role in asparaginase pharmacokinetics
van der Meer, Laurens T., Waanders, Esmé, Levers, Marloes, Venselaar, Hanka, Roeleveld, Debbie, Boos, Joachim, Lanvers, Claudia, Brüggemann, Roger J., Kuiper, Roland P., Hoogerbrugge, Peter M., van Leeuwen, Frank N., te Loo, D. Maroeska
Published in Blood (06.11.2014)
Published in Blood (06.11.2014)
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Journal Article
TP53 Aberrant B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Are Uniquely Sensitive to a Combination of Pyrimidine De Novo Synthesis Blockade and Replication Checkpoint Inhibition
Stoll, Gawin R., Van Ingen Schenau, Dorette, Cox, Willem P. J., Tang, Ziqin, Wagener, Emmely M., van der Meer, Laurens T., van Leeuwen, Frank N.
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
MLL (KMT2A)-rearranged Acute Lymphoblastic Leukemias Are Addicted to S-Adenosyl Methionine (SAM): Implications for Therapy
Tee, Trisha, Ruiter, Titine, Wajon, Danique, Wu, Shuiyan, Dahaoui, Ahmed, van Ingen Schenau, Dorette S, van der Meer, Laurens T, van Leeuwen, Frank N
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Histone Deacetylase Inhibition Restores Therapy Response in TP53mutated Acute Lymphoblastic Leukemia to Chemotherapy
Cox, Willem, Butler, Miriam, van Ingen Schenau, Dorette S, Anderson, Nadia, de Groot, Lieke, van der Meer, Laurens T, van Leeuwen, Frank N
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Loss of p53 Impairs Death Receptor Expression and Confers Resistance to CD19-Directed CAR T-Cell Therapy in B-Cell Precursor Acute Lymphoblastic Leukemia
Cox, Willem P. J., Dautzenberg, Noel M. M., Dekker, Linde, Klenovšek, Tesa, van Hoesel, Marliek, Stoll, Gawin R., Kuiper, Roland P., van der Meer, Laurens T., Calkoen, Friso G. J., Nierkens, Stefan, van Leeuwen, Frank N.
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
IKZF1 Deletions Induce Resistance to AraC in BCP-ALL Reversible By CDK8/19 Inhibition
Vervoort, Britt M T, Butler, Miriam, van Ingen Schenau, Dorette, van der Velden, Vincent H.J., Bornhauser, Beat, Bourquin, Jean-Pierre, van der Meer, Laurens T, van Leeuwen, Frank N
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article