Pharmacological characterization of GLPG1972/S201086, a potent and selective small-molecule inhibitor of ADAMTS5
Clement-Lacroix, P., Little, C.B., Smith, M.M., Cottereaux, C., Merciris, D., Meurisse, S., Mollat, P., Touitou, R., Brebion, F., Gosmini, R., De Ceuninck, F., Botez, I., Lepescheux, L., van der Aar, E., Christophe, T., Vandervoort, N., Blanqué, R., Comas, D., Deprez, P., Amantini, D.
Published in Osteoarthritis and cartilage (01.02.2022)
Published in Osteoarthritis and cartilage (01.02.2022)
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Evaluation of S201086/GLPG1972, an ADAMTS-5 inhibitor, for the treatment of knee osteoarthritis in ROCCELLA: a phase 2 randomized clinical trial
Schnitzer, T., Pueyo, M., Deckx, H., van der Aar, E., Bernard, K., Hatch, S., van der Stoep, M., Grankov, S., Phung, D., Imbert, O., Chimits, D., Muller, K., Hochberg, M.C., Bliddal, H., Wirth, W., Eckstein, F., Conaghan, P.G.
Published in Osteoarthritis and cartilage (01.07.2023)
Published in Osteoarthritis and cartilage (01.07.2023)
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OP0258 Efficacy of the highly selective adamts-5 inhibitor glpg1972 in the rat meniscectomy model
Lepescheux, L., Clement-Lacroix, P., Merciris, D., Meurisse, S., Borgonovi, M., Cottereaux, C., Mollat, P., Brebion, F., Gosmini, R., De Ceuninck, F., Botez, I., van der Aar, E., Christophe, T., Vandervoort, N., Blanqué, R., Comas, D., Deprez, P., Amantini, D.
Published in Annals of the rheumatic diseases (01.06.2018)
Published in Annals of the rheumatic diseases (01.06.2018)
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GLPG1972: a potent, selective, orally available adamts-5 inhibitor for the treatment of OA
Clement-Lacroix, P, Little, C, Meurisse, S, Blanqué, R, Mollat, P, Brebion, F, Gosmini, R, De Ceuninck, F, Botez, I, Lepescheux, L, van der Aar, E, Christophe, T, Vandervoort, N, Cottereaux, C, Comas, D, Deprez, P, Amantini, D
Published in Osteoarthritis and cartilage (01.04.2017)
Published in Osteoarthritis and cartilage (01.04.2017)
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Enzyme kinetics and substrate selectivities of rat glutathione S-transferase isoenzymes towards a series of new 2-substituted 1-chloro-4-nitrobenzenes
van der Aar, E M, Buikema, D, Commandeur, J N, te Koppele, J M, van Ommen, B, van Bladeren, P J, Vermeulen, N P
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Published in Xenobiotica (01.02.1996)
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Better self-concept, better future choices? Behavioral and neural changes after a naturalistic self-concept training program for adolescents
Van der Aar, L. P. E., Peters, S., Becht, A. I., Crone, E. A.
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Published in Cognitive, affective, & behavioral neuroscience (01.04.2022)
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Interaction profile and tolerability of barnidipine
Beudeker, H J, van der Velden, J W, van der Aar, E M
Published in International journal of clinical practice. Supplement (01.11.2000)
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Published in International journal of clinical practice. Supplement (01.11.2000)
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Social media use and the not-so-imaginary audience: Behavioral and neural mechanisms underlying the influence on self-concept
Peters, S., Van der Cruijsen, R., van der Aar, L.P.E., Spaans, J.P., Becht, A.I., Crone, E.A.
Published in Developmental cognitive neuroscience (01.04.2021)
Published in Developmental cognitive neuroscience (01.04.2021)
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AB0860 STUDY DESIGN OF ROCCELLA: A PHASE 2 CLINICAL TRIAL WITH A DISEASE-MODIFYING OSTEOARTHRITIS DRUG CANDIDATE GLPG1972/S201086
Deckx, H., Van der Aar, E., Van der Stoep, M., Wooning, M., Bernard, K., Grankov, S., Imbert, O., Pueyo, M., Eckstein, F.
Published in Annals of the rheumatic diseases (01.06.2020)
Published in Annals of the rheumatic diseases (01.06.2020)
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FRI0393 BASELINE CHARACTERISTICS OF THE STUDY POPULATION IN ROCCELLA, A PHASE 2 CLINICAL TRIAL EVALUATING THE EFFICACY AND THE SAFETY OF S201086/GLPG1972 IN PATIENTS WITH KNEE OSTEOARTHRITIS
Bernard, K., Grankov, S., Van der Stoep, M., Lalande, A., Imbert, O., Phung, D., Chimits, D., Muller, K., Van der Aar, E., Deckx, H., Pueyo, M., Eckstein, F.
Published in Annals of the rheumatic diseases (01.06.2020)
Published in Annals of the rheumatic diseases (01.06.2020)
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47 POSTER UNBS5162: A new naphthalimide derivative with radiosensitizing and anti-angiogenic activity entering phase I
Mijatovic, T, DeNève, N, Bruyère, C, Simon, G, Dewelle, J, Van Quaquebeke, E, Van Der Aar, E, Van Vynckt, F, Lefranc, F, Kiss, R
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A72 MECHANISMS DRIVING FIBROSIS: Autotaxin Inhibitor Glpg1690 Affects Tgfâ-Induced Production Of The Pro-Fibrotic Mediators CTgf, Il-6 And Et-1 In Fibroblasts
Coornaert, B, Duys, I, Der Schueren, J Van, Van Der Aar, E, Heckmann, B
Published in American journal of respiratory and critical care medicine (01.01.2017)
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Published in American journal of respiratory and critical care medicine (01.01.2017)
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Efficacy and safety of s201086/GLPG1972, an ADAMTS-5 inhibitor, in patients with knee osteoarthritis: roccella, a 52-week, randomized, double-blind, dose-ranging phase 2 study
Schnitzer, T.J., Pueyo, M., Deckx, H., van der Aar, E., Bernard, K., Hatch, S., van der Stoep, M., Grankov, S., Phung, D., Imbert, O., Chimits, D., Muller, K., Hochberg, M., Bliddal, H., Eckstein, F., Conaghan, P.
Published in Osteoarthritis and cartilage (01.04.2021)
Published in Osteoarthritis and cartilage (01.04.2021)
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OP0180 Pharmacological characterization of the ADAMTS-5 inhibitor GLPG1972: an oral anti-catabolic agent for the treatment of osteoarthritis
Clement-Lacroix, P, Little, C, Blanqué, R, Meurisse, S, Mollat, P, Brebion, F, Gosmini, R, Ceuninck, F De, Botez, I, Lepescheux, L, Aar, E van der, Christophe, T, Vandervoort, N, Cottereaux, C, Comas, D, Deprez, P, Amantini, D
Published in Annals of the rheumatic diseases (01.06.2017)
Published in Annals of the rheumatic diseases (01.06.2017)
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