Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis
Cardaci, Simone, Zheng, Liang, MacKay, Gillian, van den Broek, Niels J. F., MacKenzie, Elaine D., Nixon, Colin, Stevenson, David, Tumanov, Sergey, Bulusu, Vinay, Kamphorst, Jurre J., Vazquez, Alexei, Fleming, Stewart, Schiavi, Francesca, Kalna, Gabriela, Blyth, Karen, Strathdee, Douglas, Gottlieb, Eyal
Published in Nature cell biology (01.10.2015)
Published in Nature cell biology (01.10.2015)
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Analysis of Cell Metabolism Using LC-MS and Isotope Tracers
Mackay, Gillian M, Zheng, Liang, van den Broek, Niels J F, Gottlieb, Eyal
Published in Methods in enzymology (01.01.2015)
Published in Methods in enzymology (01.01.2015)
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Convergence of immune escape strategies highlights plasticity of SARS-CoV-2 spike
Yu, Xiaodi, Juraszek, Jarek, Rutten, Lucy, Bakkers, Mark J G, Blokland, Sven, Melchers, Jelle M, van den Broek, Niels J F, Verwilligen, Annemiek Y W, Abeywickrema, Pravien, Vingerhoets, Johan, Neefs, Jean-Marc, Bakhash, Shah A Mohamed, Roychoudhury, Pavitra, Greninger, Alex, Sharma, Sujata, Langedijk, Johannes P M
Published in PLoS pathogens (01.05.2023)
Published in PLoS pathogens (01.05.2023)
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Mdm2 induces mono-ubiquitination of FOXO4
Brenkman, Arjan B, de Keizer, Peter L J, van den Broek, Niels J F, Jochemsen, A G, Burgering, Boudewijn M Th
Published in PloS one (30.07.2008)
Published in PloS one (30.07.2008)
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Mps1 Phosphorylates Borealin to Control Aurora B Activity and Chromosome Alignment
Jelluma, Nannette, Brenkman, Arjan B., van den Broek, Niels J.F., Cruijsen, Carin W.A., van Osch, Maria H.J., Lens, Susanne M.A., Medema, René H., Kops, Geert J.P.L.
Published in Cell (25.01.2008)
Published in Cell (25.01.2008)
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SIRT1 mediates FOXA2 breakdown by deacetylation in a nutrient-dependent manner
van Gent, Rogier, Di Sanza, Claudio, van den Broek, Niels J F, Fleskens, Veerle, Veenstra, Aukje, Stout, Gerdine J, Brenkman, Arjan B
Published in PloS one (29.05.2014)
Published in PloS one (29.05.2014)
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Metabolic engineering of a carbapenem antibiotic synthesis pathway in Escherichia coli
Shomar, Helena, Gontier, Sophie, van den Broek, Niels J. F., Tejeda Mora, Héctor, Noga, Marek J., Hagedoorn, Peter-Leon, Bokinsky, Gregory
Published in Nature chemical biology (01.08.2018)
Published in Nature chemical biology (01.08.2018)
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The serine/threonine phosphatase PPM1B (PP2Cβ) selectively modulates PPARγ activity
Tasdelen, Ismayil, van Beekum, Olivier, Gorbenko, Olena, Fleskens, Veerle, van den Broek, Niels J F, Koppen, Arjen, Hamers, Nicole, Berger, Ruud, Coffer, Paul J, Brenkman, Arjan B, Kalkhoven, Eric
Published in Biochemical journal (01.04.2013)
Published in Biochemical journal (01.04.2013)
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Posttranslational Control of PlsB Is Sufficient To Coordinate Membrane Synthesis with Growth in Escherichia coli
Noga, Marek J., Büke, Ferhat, van den Broek, Niels J. F., Imholz, Nicole C. E., Scherer, Nicole, Yang, Flora, Bokinsky, Gregory
Published in mBio (18.08.2020)
Published in mBio (18.08.2020)
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Modulating the therapeutic response of tumours to dietary serine and glycine starvation
Maddocks, Oliver D. K., Athineos, Dimitris, Cheung, Eric C., Lee, Pearl, Zhang, Tong, van den Broek, Niels J. F., Mackay, Gillian M., Labuschagne, Christiaan F., Gay, David, Kruiswijk, Flore, Blagih, Julianna, Vincent, David F., Campbell, Kirsteen J., Ceteci, Fatih, Sansom, Owen J., Blyth, Karen, Vousden, Karen H.
Published in Nature (London) (20.04.2017)
Published in Nature (London) (20.04.2017)
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Calibrating the Bacterial Growth Rate Speedometer: A Re-evaluation of the Relationship Between Basal ppGpp, Growth, and RNA Synthesis in Escherichia coli
Imholz, Nicole C. E., Noga, Marek J., van den Broek, Niels J. F., Bokinsky, Gregory
Published in Frontiers in microbiology (17.09.2020)
Published in Frontiers in microbiology (17.09.2020)
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Journal Article
The Adipogenic Acetyltransferase Tip60 Targets Activation Function 1 of Peroxisome Proliferator-Activated Receptor γ
van Beekum, Olivier, Brenkman, Arjan B, Grøntved, Lars, Hamers, Nicole, van den Broek, Niels J. F, Berger, Ruud, Mandrup, Susanne, Kalkhoven, Eric
Published in Endocrinology (Philadelphia) (01.04.2008)
Published in Endocrinology (Philadelphia) (01.04.2008)
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Journal Article
Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress
Schug, Zachary T., Peck, Barrie, Jones, Dylan T., Zhang, Qifeng, Grosskurth, Shaun, Alam, Israt S., Goodwin, Louise M., Smethurst, Elizabeth, Mason, Susan, Blyth, Karen, McGarry, Lynn, James, Daniel, Shanks, Emma, Kalna, Gabriela, Saunders, Rebecca E., Jiang, Ming, Howell, Michael, Lassailly, Francois, Thin, May Zaw, Spencer-Dene, Bradley, Stamp, Gordon, van den Broek, Niels J.F., Mackay, Gillian, Bulusu, Vinay, Kamphorst, Jurre J., Tardito, Saverio, Strachan, David, Harris, Adrian L., Aboagye, Eric O., Critchlow, Susan E., Wakelam, Michael J.O., Schulze, Almut, Gottlieb, Eyal
Published in Cancer cell (12.01.2015)
Published in Cancer cell (12.01.2015)
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Insulin/IGF‐1‐mediated longevity is marked by reduced protein metabolism
Stout, Gerdine J, Stigter, Edwin C A, Essers, Paul B, Mulder, Klaas W, Kolkman, Annemieke, Snijders, Dorien S, van den Broek, Niels J F, Betist, Marco C, Korswagen, Hendrik C, MacInnes, Alyson W, Brenkman, Arjan B
Published in Molecular systems biology (02.07.2013)
Published in Molecular systems biology (02.07.2013)
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A protocol for quantifying lipid peroxidation in cellular systems by F2-isoprostane analysis
Labuschagne, Christiaan F, van den Broek, Niels J F, Postma, Pjotr, Berger, Ruud, Brenkman, Arjan B
Published in PloS one (14.11.2013)
Published in PloS one (14.11.2013)
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Multi-omics & pathway analysis identify potential roles for tumor N-acetyl aspartate accumulation in murine models of castration-resistant prostate cancer
Salji, Mark J., Blomme, Arnaud, Däbritz, J. Henry M., Repiscak, Peter, Lilla, Sergio, Patel, Rachana, Sumpton, David, van den Broek, Niels J.F., Daly, Ronan, Zanivan, Sara, Leung, Hing Y.
Published in iScience (15.04.2022)
Published in iScience (15.04.2022)
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Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation
Bulusu, Vinay, Tumanov, Sergey, Michalopoulou, Evdokia, van den Broek, Niels J., MacKay, Gillian, Nixon, Colin, Dhayade, Sandeep, Schug, Zachary T., Vande Voorde, Johan, Blyth, Karen, Gottlieb, Eyal, Vazquez, Alexei, Kamphorst, Jurre J.
Published in Cell reports (Cambridge) (17.01.2017)
Published in Cell reports (Cambridge) (17.01.2017)
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