Discovery of N‑Substituted 3‑Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II
Van Zandt, Michael C, Jagdmann, G. Erik, Whitehouse, Darren L, Ji, Minkoo, Savoy, Jennifer, Potapova, Olga, Cousido-Siah, Alexandra, Mitschler, Andre, Howard, Eduardo I, Pyle, Anna Marie, Podjarny, Alberto D
Published in Journal of medicinal chemistry (12.09.2019)
Published in Journal of medicinal chemistry (12.09.2019)
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Chemical Synthesis and Characterization of Epicatechin Glucuronides and Sulfates: Bioanalytical Standards for Epicatechin Metabolite Identification
Zhang, Mingbao, Jagdmann, G. Erik, Van Zandt, Michael, Sheeler, Ryan, Beckett, Paul, Schroeter, Hagen
Published in Journal of natural products (Washington, D.C.) (22.02.2013)
Published in Journal of natural products (Washington, D.C.) (22.02.2013)
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The antimalarial activity of the pantothenamide α-PanAm is via inhibition of pantothenate phosphorylation
Chiu, Joy E., Thekkiniath, Jose, Choi, Jae-Yeon, Perrin, Benjamin A., Lawres, Lauren, Plummer, Mark, Virji, Azan Z., Abraham, Amanah, Toh, Justin Y., Zandt, Michael Van, Aly, Ahmed S. I., Voelker, Dennis R., Mamoun, Choukri Ben
Published in Scientific reports (27.10.2017)
Published in Scientific reports (27.10.2017)
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Discovery of (R)‑2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury
Van Zandt, Michael C, Whitehouse, Darren L, Golebiowski, Adam, Ji, Min Koo, Zhang, Mingbao, Beckett, R. Paul, Jagdmann, G. Erik, Ryder, Todd R, Sheeler, Ryan, Andreoli, Monica, Conway, Bruce, Mahboubi, Keyvan, D’Angelo, Gerard, Mitschler, Andre, Cousido-Siah, Alexandra, Ruiz, Francesc X, Howard, Eduardo I, Podjarny, Alberto D, Schroeter, Hagen
Published in Journal of medicinal chemistry (28.03.2013)
Published in Journal of medicinal chemistry (28.03.2013)
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Discovery of 3-[(4,5,7-Trifluorobenzothiazol-2-yl)methyl]indole-N-acetic Acid (Lidorestat) and Congeners as Highly Potent and Selective Inhibitors of Aldose Reductase for Treatment of Chronic Diabetic Complications
Van Zandt, Michael C, Jones, Michael L, Gunn, David E, Geraci, Leo S, Jones, J. Howard, Sawicki, Diane R, Sredy, Janet, Jacot, Jorge L, DiCioccio, A. Thomas, Petrova, Tatiana, Mitschler, Andre, Podjarny, Alberto D
Published in Journal of medicinal chemistry (05.05.2005)
Published in Journal of medicinal chemistry (05.05.2005)
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Small molecules that target group II introns are potent antifungal agents
Fedorova, Olga, Jagdmann, G. Erik, Adams, Rebecca L., Yuan, Lin, Van Zandt, Michael C., Pyle, Anna Marie
Published in Nature chemical biology (01.12.2018)
Published in Nature chemical biology (01.12.2018)
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Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b] pyridin-1-yl]acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications
VAN ZANDT, Michael C, DOAN, Brian, SAWICKI, Diane R, SREDY, Janet, PODJARNY, Alberto D
Published in Bioorganic & medicinal chemistry letters (01.04.2009)
Published in Bioorganic & medicinal chemistry letters (01.04.2009)
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Topical application of aminoglycoside antibiotics enhances host resistance to viral infections in a microbiota-independent manner
Gopinath, Smita, Kim, Myoungjoo V., Rakib, Tasfia, Wong, Patrick W., van Zandt, Michael, Barry, Natasha A., Kaisho, Tsuneyasu, Goodman, Andrew L., Iwasaki, Akiko
Published in Nature microbiology (01.05.2018)
Published in Nature microbiology (01.05.2018)
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Enantioselective synthesis of orthogonally protected (2R,3R)-(−)-epicatechin derivatives, key intermediates in the de novo chemical synthesis of (−)-epicatechin glucuronides and sulfates
Zhang, Mingbao, Erik Jagdmann, G., Van Zandt, Michael, Beckett, Paul, Schroeter, Hagen
Published in Tetrahedron: asymmetry (15.04.2013)
Published in Tetrahedron: asymmetry (15.04.2013)
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Design and synthesis of highly potent and selective (2-arylcarbamoyl-phenoxy)-acetic acid inhibitors of aldose reductase for treatment of chronic diabetic complications
Van Zandt, Michael C., Sibley, Evelyn O., McCann, Erin E., Combs, Kerry J., Flam, Brenda, Sawicki, Diane R., Sabetta, Al, Carrington, Anne, Sredy, Janet, Howard, Eduardo, Mitschler, Andre, Podjarny, Alberto D.
Published in Bioorganic & medicinal chemistry (01.11.2004)
Published in Bioorganic & medicinal chemistry (01.11.2004)
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특화된 사전 해소 매개체의 염에 관한 조성물 및 방법
DWORAK JESSICA J, JAGDMANN GUNNAR ERIK JR, VAN ZANDT MICHAEL C, MATHIAS GARY, SCIAVOLINO FRANK C
Year of Publication 10.04.2019
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Year of Publication 10.04.2019
Patent
아르기나제 활성을 억제시키기 위한 조성물 및 방법
PETERSEN LENE RAUNKJAER, STANTON TIMOTHY F, CHEN LIJING, WHITEHOUSE DARREN, LI JIM, PARLATI FRANCESCO, JAGDMANN GUNNAR E. JR, SJOGREN ERIC B, BILLEDEAU ROLAND J, GROSS MATTHEW I, VAN ZANDT MICHAEL
Year of Publication 22.10.2019
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Year of Publication 22.10.2019
Patent
INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS
BECKETT PAUL, GOLEBIOWSKI ADAM, KOO, JI MIN, WHITEHOUSE DARREN, RYDER TODD, VAN ZANDT MICHAEL
Year of Publication 16.09.2013
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Year of Publication 16.09.2013
Patent
Discovery of a Series of Potent, Selective, and Orally Bioavailable Nucleoside Inhibitors of CD73 That Demonstrates In Vivo Antitumor Activity
Li, Jim, Chen, Lijing, Billedeau, Roland J., Stanton, Timothy F., Chiang, John T. P., Lee, Clarissa C., Li, Weiqun, Steggerda, Susanne, Emberley, Ethan, Gross, Matthew, Bhupathi, Deepthi, Che, Xiaoying, Chen, Jason, Dang, Rosalyn, Huang, Tony, Ma, Yong, MacKinnon, Andrew, Makkouk, Amani, Marguier, Gisele, Neou, Silinda, Sotirovska, Natalija, Spurlock, Sandra, Zhang, Jing, Zhang, Winter, van Zandt, Michael, Yuan, Lin, Savoy, Jennifer, Parlati, Francesco, Sjogren, Eric B.
Published in Journal of medicinal chemistry (12.01.2023)
Published in Journal of medicinal chemistry (12.01.2023)
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