Monoubiquitination by the human Fanconi anemia core complex clamps FANCI:FANCD2 on DNA in filamentous arrays
Tan, Winnie, van Twest, Sylvie, Leis, Andrew, Bythell-Douglas, Rohan, Murphy, Vincent J, Sharp, Michael, Parker, Michael W, Crismani, Wayne, Deans, Andrew J
Published in eLife (13.03.2020)
Published in eLife (13.03.2020)
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Methodology for the identification of small molecule inhibitors of the Fanconi Anaemia ubiquitin E3 ligase complex
Sharp, Michael F., Murphy, Vince J., Twest, Sylvie Van, Tan, Winnie, Lui, Jennii, Simpson, Kaylene J., Deans, Andrew J., Crismani, Wayne
Published in Scientific reports (14.05.2020)
Published in Scientific reports (14.05.2020)
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Mechanism of Ubiquitination and Deubiquitination in the Fanconi Anemia Pathway
van Twest, Sylvie, Murphy, Vincent J., Hodson, Charlotte, Tan, Winnie, Swuec, Paolo, O’Rourke, Julienne J., Heierhorst, Jörg, Crismani, Wayne, Deans, Andrew J.
Published in Molecular cell (19.01.2017)
Published in Molecular cell (19.01.2017)
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Mechanism of structure-specific DNA binding by the FANCM branchpoint translocase
Abbouche, Lara, Murphy, Vincent J, Gao, Jixuan, van Twest, Sylvie, Sobinoff, Alexander P, Auweiler, Karen M, Pickett, Hilda A, Bythell-Douglas, Rohan, Deans, Andrew J
Published in Nucleic acids research (14.10.2024)
Published in Nucleic acids research (14.10.2024)
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Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability
Hodson, Charlotte, Low, Jason K K, van Twest, Sylvie, Jones, Samuel E, Swuec, Paolo, Murphy, Vincent, Tsukada, Kaima, Fawkes, Matthew, Bythell-Douglas, Rohan, Davies, Adelina, Holien, Jessica K, O'Rourke, Julienne J, Parker, Benjamin L, Glaser, Astrid, Parker, Michael W, Mackay, Joel P, Blackford, Andrew N, Costa, Alessandro, Deans, Andrew J
Published in Proceedings of the National Academy of Sciences - PNAS (08.02.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (08.02.2022)
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Journal Article
The FA Core Complex Contains a Homo-dimeric Catalytic Module for the Symmetric Mono-ubiquitination of FANCI-FANCD2
Swuec, Paolo, Renault, Ludovic, Borg, Aaron, Shah, Fenil, Murphy, Vincent J., van Twest, Sylvie, Snijders, Ambrosius P., Deans, Andrew J., Costa, Alessandro
Published in Cell reports (Cambridge) (17.01.2017)
Published in Cell reports (Cambridge) (17.01.2017)
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Journal Article
Preparation and purification of mono-ubiquitinated proteins using Avi-tagged ubiquitin
Tan, Winnie, Murphy, Vincent J, Charron, Aude, van Twest, Sylvie, Sharp, Michael, Constantinou, Angelos, Parker, Michael W, Crismani, Wayne, Bythell-Douglas, Rohan, Deans, Andrew J
Published in PloS one (24.02.2020)
Published in PloS one (24.02.2020)
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Branchpoint translocation by fork remodelers as a general mechanism of R-loop removal
Hodson, Charlotte, van Twest, Sylvie, Dylewska, Malgorzata, O’Rourke, Julienne J., Tan, Winnie, Murphy, Vincent J., Walia, Mannu, Abbouche, Lara, Nieminuszczy, Jadwiga, Dunn, Elyse, Bythell-Douglas, Rohan, Heierhorst, Jörg, Niedzwiedz, Wojciech, Deans, Andrew J.
Published in Cell reports (Cambridge) (06.12.2022)
Published in Cell reports (Cambridge) (06.12.2022)
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Association of clinical severity with FANCB variant type in Fanconi anemia
Jung, Moonjung, Ramanagoudr-Bhojappa, Ramanagouda, van Twest, Sylvie, Rosti, Rasim Ozgur, Murphy, Vincent, Tan, Winnie, Donovan, Frank X., Lach, Francis P., Kimble, Danielle C., Jiang, Caroline S., Vaughan, Roger, Mehta, Parinda A., Pierri, Filomena, Dufour, Carlo, Auerbach, Arleen D., Deans, Andrew J., Smogorzewska, Agata, Chandrasekharappa, Settara C.
Published in Blood (30.04.2020)
Published in Blood (30.04.2020)
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Clinical severity in Fanconi anemia correlates with residual function of FANCB missense variants
Jung, Moonjung, Ramanagoudr-Bhojappa, Ramanagouda, Sylvie Van Twest, Rosti, Rasim Ozgur, Murphy, Vincent J, Tan, Winnie, Donovan, Frank, Lach, Francis, Kimble, Danielle, Jiang, Caroline, Vaughan, Roger, Mehta, Parinda, Pierri, Filomena, Doufour, Carlo, Auerbach, Arleen D, Deans, Andrew J, Smogorzewska, Agata, Chandrasekharappa, Settara C
Published in bioRxiv (18.09.2019)
Published in bioRxiv (18.09.2019)
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