Identification and Development of Biphenyl Substituted Iminosugars as Improved Dual Glucosylceramide Synthase/Neutral Glucosylceramidase Inhibitors
Ghisaidoobe, Amar T, van den Berg, Richard J. B. H. N, Butt, Saleem S, Strijland, Anneke, Donker-Koopman, Wilma E, Scheij, Saskia, van den Nieuwendijk, Adrianus M. C. H, Koomen, Gerrit-Jan, van Loevezijn, Arnold, Leemhuis, Mark, Wennekes, Tom, van der Stelt, Mario, van der Marel, Gijsbert A, van Boeckel, Constant A. A, Aerts, Johannes M. F. G, Overkleeft, Herman S
Published in Journal of medicinal chemistry (13.11.2014)
Published in Journal of medicinal chemistry (13.11.2014)
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Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C
Allen, John D, van Loevezijn, Arnold, Lakhai, Jeany M, van der Valk, Martin, van Tellingen, Olaf, Reid, Glen, Schellens, Jan H M, Koomen, Gerrit-Jan, Schinkel, Alfred H
Published in Molecular cancer therapeutics (01.04.2002)
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Published in Molecular cancer therapeutics (01.04.2002)
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N′-(Arylsulfonyl)pyrazoline-1-carboxamidines as Novel, Neutral 5-Hydroxytryptamine 6 Receptor (5-HT6R) Antagonists with Unique Structural Features
van Loevezijn, Arnold, Venhorst, Jennifer, Iwema Bakker, Wouter I, de Korte, Cor G, de Looff, Wouter, Verhoog, Stefan, van Wees, Jan-Willem, van Hoeve, Martijn, van de Woestijne, Rob P, van der Neut, Martina A. W, Borst, Alice J. M, van Dongen, Maria J. P, de Bruin, Natasja M. W. J, Keizer, Hiskias G, Kruse, Chris G
Published in Journal of medicinal chemistry (27.10.2011)
Published in Journal of medicinal chemistry (27.10.2011)
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Optimization of N'-(arylsulfonyl)pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT sub(6) antagonistic binding pocket
Loevezijn, Arnold van, Venhorst, Jennifer, Bakker, Wouter IIwema, Lange, Jos HM, Looff, Wouter de, Henzen, Remco, Vries, Jelle de, Woestijne, Rob Pvan de, Hartog, Arnold Pden, Verhoog, Stefan, van der Neut, Martina AW, Bruin, Natasja MWJde, Kruse, Chris G
Published in Bioorganic & medicinal chemistry letters (15.03.2016)
Published in Bioorganic & medicinal chemistry letters (15.03.2016)
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Optimization of N ′-(arylsulfonyl)pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT 6 antagonistic binding pocket
van Loevezijn, Arnold, Venhorst, Jennifer, Iwema Bakker, Wouter I., Lange, Jos H.M., de Looff, Wouter, Henzen, Remco, de Vries, Jelle, van de Woestijne, Rob P., den Hartog, Arnold P., Verhoog, Stefan, van der Neut, Martina A.W., de Bruin, Natasja M.W.J., Kruse, Chris G.
Published in Bioorganic & medicinal chemistry letters (01.03.2016)
Published in Bioorganic & medicinal chemistry letters (01.03.2016)
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Journal Article
Optimization of N′-(arylsulfonyl)pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT6 antagonistic binding pocket
van Loevezijn, Arnold, Venhorst, Jennifer, Iwema Bakker, Wouter I., Lange, Jos H.M., de Looff, Wouter, Henzen, Remco, de Vries, Jelle, van de Woestijne, Rob P., den Hartog, Arnold P., Verhoog, Stefan, van der Neut, Martina A.W., de Bruin, Natasja M.W.J., Kruse, Chris G.
Published in Bioorganic & medicinal chemistry letters (15.03.2016)
Published in Bioorganic & medicinal chemistry letters (15.03.2016)
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A novel atom-efficient, one-pot synthesis of sulfonylguanidines and sulfamoylguanidines
Lange, Jos H.M., Verhoog, Stefan, Sanders, Hans J., van Loevezijn, Arnold, Kruse, Chris G.
Published in Tetrahedron letters (22.06.2011)
Published in Tetrahedron letters (22.06.2011)
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Function of the ABC transporters, P-glycoprotein, multidrug resistance protein and breast cancer resistance protein, in minimal residual disease in acute myeloid leukemia
van der Pol, MA, Broxterman, HJ, Pater, JM, Feller, N, van der Maas, M, Weijers, GW, Scheffer, GL, Allen, JD, Scheper, RJ, van Loevezijn, A, Ossenkoppele, GJ, Schuurhuis, GJ
Published in Haematologica (Roma) (01.02.2003)
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Published in Haematologica (Roma) (01.02.2003)
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Potent and Specific Inhibition of the Breast Cancer Resistance Protein Multidrug Transporter in Vitro and in Mouse Intestine by a Novel Analogue of Fumitremorgin C 1 This work was supported in part by grant NKI 97-1433 from the Dutch Cancer Society (to A. H. S.). Synthesis investigations by A. v. L. and G-J. K. were supported by the Netherlands Research Council for Chemical Sciences (NWO/CW) and the Netherlands Technology Foundation (STW).1
John D. Allen, Arnold van Loevezijn, Jeany M. Lakhai, Martin van der Valk, Olaf van Tellingen, Glen Reid, Jan H. M. Schellens, Gerrit-Jan Koomen, Alfred H. Schinkel
Published in Molecular cancer therapeutics (01.04.2002)
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Published in Molecular cancer therapeutics (01.04.2002)
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