Statins as Anticancer Agents in the Era of Precision Medicine
Longo, Joseph, van Leeuwen, Jenna E, Elbaz, Mohamad, Branchard, Emily, Penn, Linda Z
Published in Clinical cancer research (15.11.2020)
Published in Clinical cancer research (15.11.2020)
Get full text
Journal Article
Statin-Induced Cancer Cell Death Can Be Mechanistically Uncoupled from Prenylation of RAS Family Proteins
Yu, Rosemary, Longo, Joseph, van Leeuwen, Jenna E, Mullen, Peter J, Ba-Alawi, Wail, Haibe-Kains, Benjamin, Penn, Linda Z
Published in Cancer research (Chicago, Ill.) (01.03.2018)
Published in Cancer research (Chicago, Ill.) (01.03.2018)
Get full text
Journal Article
The mevalonate pathway is an actionable vulnerability of t(4;14)-positive multiple myeloma
Longo, Joseph, Smirnov, Petr, Li, Zhihua, Branchard, Emily, van Leeuwen, Jenna E., Licht, Jonathan D., Haibe-Kains, Benjamin, Andrews, David W., Keats, Jonathan J., Pugh, Trevor J., Trudel, Suzanne, Penn, Linda Z.
Published in Leukemia (01.03.2021)
Published in Leukemia (01.03.2021)
Get full text
Journal Article
Computational pharmacogenomic screen identifies drugs that potentiate the anti-breast cancer activity of statins
van Leeuwen, Jenna E., Ba-Alawi, Wail, Branchard, Emily, Cruickshank, Jennifer, Schormann, Wiebke, Longo, Joseph, Silvester, Jennifer, Gross, Peter L., Andrews, David W., Cescon, David W., Haibe-Kains, Benjamin, Penn, Linda Z., Gendoo, Deena M. A.
Published in Nature communications (24.10.2022)
Published in Nature communications (24.10.2022)
Get full text
Journal Article
An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer
Longo, Joseph, Mullen, Peter J., Yu, Rosemary, van Leeuwen, Jenna E., Masoomian, Mehdi, Woon, Dixon T.S., Wang, Yuzhuo, Chen, Eric X., Hamilton, Robert J., Sweet, Joan M., van der Kwast, Theodorus H., Fleshner, Neil E., Penn, Linda Z.
Published in Molecular metabolism (Germany) (01.07.2019)
Published in Molecular metabolism (Germany) (01.07.2019)
Get full text
Journal Article
Mevalonate Pathway Inhibition Slows Breast Cancer Metastasis via Reduced N -glycosylation Abundance and Branching
Yu, Rosemary, Longo, Joseph, van Leeuwen, Jenna E, Zhang, Cunjie, Branchard, Emily, Elbaz, Mohamad, Cescon, David W, Drake, Richard R, Dennis, James W, Penn, Linda Z
Published in Cancer research (Chicago, Ill.) (15.05.2021)
Published in Cancer research (Chicago, Ill.) (15.05.2021)
Get full text
Journal Article
Topoisomerase 1 Inhibition in MYC-Driven Cancer Promotes Aberrant R-Loop Accumulation to Induce Synthetic Lethality
Lin, Peter, Lourenco, Corey, Cruickshank, Jennifer, Palomero, Luis, van Leeuwen, Jenna E, Tong, Amy H Y, Chan, Katherine, El Ghamrasni, Samah, Pujana, Miquel Angel, Cescon, David W, Moffat, Jason, Penn, Linda Z
Published in Cancer research (Chicago, Ill.) (15.12.2023)
Published in Cancer research (Chicago, Ill.) (15.12.2023)
Get full text
Journal Article