A human monoclonal antibody blocking SARS-CoV-2 infection
Wang, Chunyan, Li, Wentao, Drabek, Dubravka, Okba, Nisreen M. A., van Haperen, Rien, Osterhaus, Albert D. M. E., van Kuppeveld, Frank J. M., Haagmans, Bart L., Grosveld, Frank, Bosch, Berend-Jan
Published in Nature Communications (04.05.2020)
Published in Nature Communications (04.05.2020)
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A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies
Wang, Chunyan, van Haperen, Rien, Gutiérrez-Álvarez, Javier, Li, Wentao, Okba, Nisreen M. A., Albulescu, Irina, Widjaja, Ivy, van Dieren, Brenda, Fernandez-Delgado, Raul, Sola, Isabel, Hurdiss, Daniel L., Daramola, Olalekan, Grosveld, Frank, van Kuppeveld, Frank J. M., Haagmans, Bart L., Enjuanes, Luis, Drabek, Dubravka, Bosch, Berend-Jan
Published in Nature communications (17.03.2021)
Published in Nature communications (17.03.2021)
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Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes
Wang, Chunyan, Hesketh, Emma L., Shamorkina, Tatiana M., Li, Wentao, Franken, Peter J., Drabek, Dubravka, van Haperen, Rien, Townend, Sarah, van Kuppeveld, Frank J. M., Grosveld, Frank, Ranson, Neil A., Snijder, Joost, de Groot, Raoul J., Hurdiss, Daniel L., Bosch, Berend-Jan
Published in Nature communications (25.05.2022)
Published in Nature communications (25.05.2022)
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Publisher Correction: A human monoclonal antibody blocking SARS-CoV-2 infection
Wang, Chunyan, Li, Wentao, Drabek, Dubravka, Okba, Nisreen M. A., van Haperen, Rien, Osterhaus, Albert D. M. E., van Kuppeveld, Frank J. M., Haagmans, Bart L., Grosveld, Frank, Bosch, Berend-Jan
Published in Nature communications (14.05.2020)
Published in Nature communications (14.05.2020)
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Overexpression of endothelial nitric oxide synthase suppresses features of allergic asthma in mice
Ten Broeke, Robert, De Crom, Rini, Van Haperen, Rien, Verweij, Vivienne, Leusink-Muis, Thea, Van Ark, Ingrid, De Clerck, Fred, Nijkamp, Frans P, Folkerts, Gert
Published in Respiratory research (05.04.2006)
Published in Respiratory research (05.04.2006)
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Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress
CHENG, Caroline, TEMPEL, Dennie, VAN HAPEREN, Rien, VAN DER BAAN, Arjen, GROSVELD, Frank, DAEMEN, Mat J. A. P, KRAMS, Rob, DE CROM, Rini
Published in Circulation (New York, N.Y.) (13.06.2006)
Published in Circulation (New York, N.Y.) (13.06.2006)
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Neutralizing antibodies reveal cryptic vulnerabilities and interdomain crosstalk in the porcine deltacoronavirus spike protein
Du, Wenjuan, Debski-Antoniak, Oliver, Drabek, Dubravka, van Haperen, Rien, van Dortmondt, Melissa, van der Lee, Joline, Drulyte, Ieva, van Kuppeveld, Frank J. M., Grosveld, Frank, Hurdiss, Daniel L., Bosch, Berend-Jan
Published in Nature communications (22.06.2024)
Published in Nature communications (22.06.2024)
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WNT/beta-catenin signalling interrupts a senescence-induction cascade in human mesenchymal stem cells that restricts their expansion
Lehmann, Johannes, Narcisi, Roberto, Franceschini, Natasja, Chatzivasileiou, Danai, Boer, Cindy G., Koevoet, Wendy J. L. M., Putavet, Diana, Drabek, Dubravka, van Haperen, Rien, de Keizer, Peter L. J., van Osch, Gerjo J. V. M., ten Berge, Derk
Published in Cellular and molecular life sciences : CMLS (01.02.2022)
Published in Cellular and molecular life sciences : CMLS (01.02.2022)
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Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein
Widjaja, Ivy, Wang, Chunyan, van Haperen, Rien, Gutiérrez-Álvarez, Javier, van Dieren, Brenda, Okba, Nisreen M.A., Raj, V. Stalin, Li, Wentao, Fernandez-Delgado, Raul, Grosveld, Frank, van Kuppeveld, Frank J. M., Haagmans, Bart L., Enjuanes, Luis, Drabek, Dubravka, Bosch, Berend-Jan
Published in Emerging microbes & infections (01.01.2019)
Published in Emerging microbes & infections (01.01.2019)
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Spatiotemporal endothelial cell – pericyte association in tumors as shown by high resolution 4D intravital imaging
Seynhaeve, Ann L. B., Oostinga, Douwe, van Haperen, Rien, Eilken, Hanna M., Adams, Susanne, Adams, Ralf H., ten Hagen, Timo L. M.
Published in Scientific reports (25.06.2018)
Published in Scientific reports (25.06.2018)
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Generation and preclinical evaluation of a human heavy-chain-only antibody recognizing the membrane-bound tumor-associated antigen mesothelin
Janssens, Rick, van Haperen, Rien, van der Reijden, Michael, Maas, Alex, Wang, Jingsong, Grosveld, Frank, Drabek, Dubravka
Published in Frontiers in Chemical Biology (22.07.2024)
Published in Frontiers in Chemical Biology (22.07.2024)
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An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern
Du, Wenjuan, Hurdiss, Daniel L, Drabek, Dubravka, Mykytyn, Anna Z, Kaiser, Franziska K, González-Hernández, Mariana, Muñoz-Santos, Diego, Lamers, Mart M, van Haperen, Rien, Li, Wentao, Drulyte, Ieva, Wang, Chunyan, Sola, Isabel, Armando, Federico, Beythien, Georg, Ciurkiewicz, Malgorzata, Baumgärtner, Wolfgang, Guilfoyle, Kate, Smits, Tony, van der Lee, Joline, van Kuppeveld, Frank J M, van Amerongen, Geert, Haagmans, Bart L, Enjuanes, Luis, Osterhaus, Albert D M E, Grosveld, Frank, Bosch, Berend-Jan
Published in Science immunology (29.07.2022)
Published in Science immunology (29.07.2022)
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Avidity engineering of human heavy-chain-only antibodies mitigates neutralization resistance of SARS-CoV-2 variants
Du, Wenjuan, Janssens, Rick, Mykytyn, Anna Z, Li, Wentao, Drabek, Dubravka, van Haperen, Rien, Chatziandreou, Marianthi, Rissmann, Melanie, van der Lee, Joline, van Dortmondt, Melissa, Martin, Itziar Serna, van Kuppeveld, Frank J M, Hurdiss, Daniel L, Haagmans, Bart L, Grosveld, Frank, Bosch, Berend-Jan
Published in Frontiers in immunology (21.02.2023)
Published in Frontiers in immunology (21.02.2023)
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Shear stress-induced changes in atherosclerotic plaque composition are modulated by chemokines
Cheng, Caroline, Tempel, Dennie, van Haperen, Rien, de Boer, Hetty C, Segers, Dolf, Huisman, Martin, van Zonneveld, Anton Jan, Leenen, Pieter J M, van der Steen, Anton, Serruys, Patrick W, de Crom, Rini, Krams, Rob
Published in The Journal of clinical investigation (01.03.2007)
Published in The Journal of clinical investigation (01.03.2007)
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Large variations in absolute wall shear stress levels within one species and between species
Cheng, Caroline, Helderman, Frank, Tempel, Dennie, Segers, Dolf, Hierck, Beerend, Poelmann, Rob, van Tol, Arie, Duncker, Dirk J, Robbers-Visser, Danielle, Ursem, Nicolette T.C, van Haperen, Rien, Wentzel, Jolanda J, Gijsen, Frank, van der Steen, Anton F.W, de Crom, Rini, Krams, Rob
Published in Atherosclerosis (01.12.2007)
Published in Atherosclerosis (01.12.2007)
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Shear stress affects the intracellular distribution of eNOS: direct demonstration by a novel in vivo technique
Cheng, Caroline, van Haperen, Rien, de Waard, Monique, van Damme, Luc C.A., Tempel, Dennie, Hanemaaijer, Laurens, van Cappellen, Gert W.A., Bos, Joop, Slager, Cornelis J., Duncker, Dirk J., van der Steen, Anton F.W., de Crom, Rini, Krams, Rob
Published in Blood (01.12.2005)
Published in Blood (01.12.2005)
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High throughput identification of human monoclonal antibodies and heavy-chain-only antibodies to treat snakebite
Slagboom, Julien, Lewis, Abigail H., Schouten, Wietse M., van Haperen, Rien, Veltman, Mieke, Bittenbinder, Mátyás A., Vonk, Freek J., Casewell, Nicholas R., Grosveld, Frank, Drabek, Dubravka, Kool, Jeroen
Published in Toxicon X (01.03.2024)
Published in Toxicon X (01.03.2024)
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Beneficial effects of exercise training after myocardial infarction require full eNOS expression
de Waard, Monique C, van Haperen, Rien, Soullié, Thomas, Tempel, Dennie, de Crom, Rini, Duncker, Dirk J
Published in Journal of molecular and cellular cardiology (01.06.2010)
Published in Journal of molecular and cellular cardiology (01.06.2010)
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Heavy chain-only antibodies and tetravalent bispecific antibody neutralizing Staphylococcus aureus leukotoxins
Laventie, Benoît-Joseph, Rademaker, Hendrik Jan, Saleh, Maher, de Boer, Ernie, Janssens, Rick, Bourcier, Tristan, Subilia, Audrey, Marcellin, Luc, van Haperen, Rien, Lebbink, Joyce H. G, Chen, Tao, Prévost, Gilles, Grosveld, Frank, Drabek, Dubravka
Published in Proceedings of the National Academy of Sciences - PNAS (27.09.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (27.09.2011)
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Endothelial Nitric Oxide Synthase Overexpression Attenuates Congestive Heart Failure in Mice
Jones, Steven P., James J. M. Greer, van Haperen, Rien, Duncker, Dirk J., de Crom, Rini, Lefer, David J.
Published in Proceedings of the National Academy of Sciences - PNAS (15.04.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (15.04.2003)
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