BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis
McArthur, Kate, Whitehead, Lachlan W, Heddleston, John M, Li, Lucy, Padman, Benjamin S, Oorschot, Viola, Geoghegan, Niall D, Chappaz, Stephane, Davidson, Sophia, San Chin, Hui, Lane, Rachael M, Dramicanin, Marija, Saunders, Tahnee L, Sugiana, Canny, Lessene, Romina, Osellame, Laura D, Chew, Teng-Leong, Dewson, Grant, Lazarou, Michael, Ramm, Georg, Lessene, Guillaume, Ryan, Michael T, Rogers, Kelly L, van Delft, Mark F, Kile, Benjamin T
Published in Science (American Association for the Advancement of Science) (23.02.2018)
Published in Science (American Association for the Advancement of Science) (23.02.2018)
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Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production
White, Michael J., McArthur, Kate, Metcalf, Donald, Lane, Rachael M., Cambier, John C., Herold, Marco J., van Delft, Mark F., Bedoui, Sammy, Lessene, Guillaume, Ritchie, Matthew E., Huang, David C.S., Kile, Benjamin T.
Published in Cell (18.12.2014)
Published in Cell (18.12.2014)
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MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex
Djajawi, Tirta Mario, Liu, Lei, Gong, Jia-nan, Huang, Allan Shuai, Luo, Ming-jie, Xu, Zhen, Okamoto, Toru, Call, Melissa J., Huang, David C. S., van Delft, Mark F.
Published in Cell death and differentiation (01.08.2020)
Published in Cell death and differentiation (01.08.2020)
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Fluorescence Interference Contrast-enabled structures improve the microarrays performance
Dobroiu, S., van Delft, F.C.M.J.M., Aveyard-Hanson, J., Shetty, Prasad, Nicolau, D.V.
Published in Biosensors & bioelectronics (01.01.2019)
Published in Biosensors & bioelectronics (01.01.2019)
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Clonal origins of ETV6-RUNX1+ acute lymphoblastic leukemia: studies in monozygotic twins
Alpar, D, Wren, D, Ermini, L, Mansur, M B, van Delft, F W, Bateman, C M, Titley, I, Kearney, L, Szczepanski, T, Gonzalez, D, Ford, A M, Potter, N E, Greaves, M
Published in Leukemia (01.04.2015)
Published in Leukemia (01.04.2015)
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The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL
Jacobsen, Annette V., Pierotti, Catia L., Lowes, Kym N., Au, Amanda E., Zhang, Ying, Etemadi, Nima, Fitzgibbon, Cheree, Kersten, Wilhelmus J. A., Samson, André L., van Delft, Mark F., Huang, David C. S., Sabroux, Hélène Jousset, Lessene, Guillaume, Silke, John, Murphy, James M.
Published in Cell death & disease (01.04.2022)
Published in Cell death & disease (01.04.2022)
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The threshold at which substrate nanogroove dimensions may influence fibroblast alignment and adhesion
Loesberg, W.A, te Riet, J, van Delft, F.C.M.J.M, Schön, P, Figdor, C.G, Speller, S, van Loon, J.J.W.A, Walboomers, X.F, Jansen, J.A
Published in Biomaterials (01.09.2007)
Published in Biomaterials (01.09.2007)
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The influence of nanoscale topographical cues on initial osteoblast morphology and migration
Lamers, E, van Horssen, R, te Riet, J, van Delft, F Cmjm, Luttge, R, Walboomers, X F, Jansen, J A
Published in European cells & materials (09.11.2010)
Published in European cells & materials (09.11.2010)
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VDAC2 enables BAX to mediate apoptosis and limit tumor development
Chin, Hui San, Li, Mark X., Tan, Iris K. L., Ninnis, Robert L., Reljic, Boris, Scicluna, Kristen, Dagley, Laura F., Sandow, Jarrod J., Kelly, Gemma L., Samson, Andre L., Chappaz, Stephane, Khaw, Seong L., Chang, Catherine, Morokoff, Andrew, Brinkmann, Kerstin, Webb, Andrew, Hockings, Colin, Hall, Cathrine M., Kueh, Andrew J., Ryan, Michael T., Kluck, Ruth M., Bouillet, Philippe, Herold, Marco J., Gray, Daniel H. D., Huang, David C. S., van Delft, Mark F., Dewson, Grant
Published in Nature communications (26.11.2018)
Published in Nature communications (26.11.2018)
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CD2-positive B-cell precursor acute lymphoblastic leukemia with an early switch to the monocytic lineage
Slamova, L, Starkova, J, Fronkova, E, Zaliova, M, Reznickova, L, van Delft, F W, Vodickova, E, Volejnikova, J, Zemanova, Z, Polgarova, K, Cario, G, Figueroa, M, Kalina, T, Fiser, K, Bourquin, J P, Bornhauser, B, Dworzak, M, Zuna, J, Trka, J, Stary, J, Hrusak, O, Mejstrikova, E
Published in Leukemia (01.03.2014)
Published in Leukemia (01.03.2014)
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Genome complexity in acute lymphoblastic leukemia is revealed by array-based comparative genomic hybridization
STREFFORD, J. C, WORLEY, H, GRIFFITHS, M, HING, S, ROSS, F. M, TALLEY, P, SAHA, V, MOORMAN, A. V, HARRISON, C. J, BARBER, K, WRIGHT, S, STEWART, A. R. M, ROBINSON, H. M, BETTNEY, G, VAN DELFT, F. W, ATHERTON, M. G, DAVIES, T
Published in Oncogene (21.06.2007)
Published in Oncogene (21.06.2007)
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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
van Delft, Mark F., Wei, Andrew H., Mason, Kylie D., Vandenberg, Cassandra J., Chen, Lin, Czabotar, Peter E., Willis, Simon N., Scott, Clare L., Day, Catherine L., Cory, Suzanne, Adams, Jerry M., Roberts, Andrew W., Huang, David C.S.
Published in Cancer cell (01.11.2006)
Published in Cancer cell (01.11.2006)
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Key residues in the VDAC2-BAK complex can be targeted to modulate apoptosis
Yuan, Zheng, van Delft, Mark F, Li, Mark Xiang, Sumardy, Fransisca, Smith, Brian J, Huang, David C S, Lessene, Guillaume, Khakam, Yelena, Jin, Ruitao, He, Sitong, Smith, Nicholas A, Birkinshaw, Richard W, Czabotar, Peter E, Dewson, Grant
Published in PLoS biology (02.05.2024)
Published in PLoS biology (02.05.2024)
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Protracted dormancy of pre-leukemic stem cells
Ford, A M, Mansur, M B, Furness, C L, van Delft, F W, Okamura, J, Suzuki, T, Kobayashi, H, Kaneko, Y, Greaves, M
Published in Leukemia (01.11.2015)
Published in Leukemia (01.11.2015)
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Journal Article
HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death
Jacobsen, A V, Lowes, K N, Tanzer, M C, Lucet, I S, Hildebrand, J M, Petrie, E J, van Delft, M F, Liu, Z, Conos, S A, Zhang, J-G, Huang, D C S, Silke, J, Lessene, G, Murphy, J M
Published in Cell death & disease (14.01.2016)
Published in Cell death & disease (14.01.2016)
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Structural insights into the degradation of Mcl-1 induced by BH3 domains
Czabotar, Peter E, Lee, Erinna F, van Delft, Mark F, Day, Catherine L, Smith, Brian J, Huang, David C.S, Fairlie, W. Douglas, Hinds, Mark G, Colman, Peter M
Published in Proceedings of the National Academy of Sciences - PNAS (10.04.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (10.04.2007)
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AML1/ETO and POU4F1 synergy drives B-lymphoid gene expression typical of t(8;21) acute myeloid leukemia
Dunne, J, Mannari, D, Farzaneh, T, Gessner, A, van Delft, F W, Heidenreich, O, Young, B D, Gascoyne, D M
Published in Leukemia (01.05.2012)
Published in Leukemia (01.05.2012)
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Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis
Okamoto, Toru, Coultas, Leigh, Metcalf, Donald, van Delft, Mark F., Glaser, Stefan P., Takiguchi, Megumi, Strasser, Andreas, Bouillet, Philippe, Adams, Jerry M., Huang, David C. S.
Published in Proceedings of the National Academy of Sciences - PNAS (07.01.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (07.01.2014)
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Discovery of Potent and Selective Benzothiazole Hydrazone Inhibitors of Bcl‑XL
Sleebs, Brad E, Kersten, Wilhemus J. A, Kulasegaram, Sanji, Nikolakopoulos, George, Hatzis, Effie, Moss, Rebecca M, Parisot, John P, Yang, Hong, Czabotar, Peter E, Fairlie, W. Douglas, Lee, Erinna F, Adams, Jerry M, Chen, Lin, van Delft, Mark F, Lowes, Kym N, Wei, Andrew, Huang, David C.S, Colman, Peter M, Street, Ian P, Baell, Jonathan B, Watson, Keith, Lessene, Guillaume
Published in Journal of medicinal chemistry (11.07.2013)
Published in Journal of medicinal chemistry (11.07.2013)
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