TMC647055, a Potent Nonnucleoside Hepatitis C Virus NS5B Polymerase Inhibitor with Cross-Genotypic Coverage
DEVOGELAERE, Benoit, BERKE, Jan Martin, LENZ, Oliver, CUMMINGS, Maxwell D, CLAYTON, Reginald F, VENDEVILLE, Sandrine, RABOISSON, Pierre, SIMMEN, Kenneth A, FANNING, Gregory C, LIN, Tse-I, VIJGEN, Leen, DEHERTOGH, Pascale, FRANSEN, Els, CLEIREN, Erna, VAN DER HELM, Liesbet, NYANGUILE, Origène, TAHRI, Abdellah, AMSSOMS, Katie
Published in Antimicrobial Agents and Chemotherapy (01.09.2012)
Published in Antimicrobial Agents and Chemotherapy (01.09.2012)
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Structure-Based Macrocyclization Yields Hepatitis C Virus NS5B Inhibitors with Improved Binding Affinities and Pharmacokinetic Properties
Cummings, Maxwell D., Lin, Tse-I, Hu, Lili, Tahri, Abdellah, McGowan, David, Amssoms, Katie, Last, Stefaan, Devogelaere, Benoit, Rouan, Marie-Claude, Vijgen, Leen, Berke, Jan Martin, Dehertogh, Pascale, Fransen, Els, Cleiren, Erna, van der Helm, Liesbet, Fanning, Gregory, Van Emelen, Kristof, Nyanguile, Origène, Simmen, Kenny, Raboisson, Pierre, Vendeville, Sandrine
Published in Angewandte Chemie (International ed.) (07.05.2012)
Published in Angewandte Chemie (International ed.) (07.05.2012)
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Binding-Site Identification and Genotypic Profiling of Hepatitis C Virus Polymerase Inhibitors
PAUWELS, Frederik, MOSTMANS, Wendy, SIMMEN, Kenneth A, QUIRYNEN, Ludo M. M, VAN DER HELM, Liesbet, BOUTTON, Carlo W, RUEFF, Anne-Stéphanie, CLEIREN, Erna, RABOISSON, Pierre, SURLERAUX, Dominique, NYANGUILE, Origène
Published in Journal of Virology (01.07.2007)
Published in Journal of Virology (01.07.2007)
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1,5-Benzodiazepines, a Novel Class of Hepatitis C Virus Polymerase Nonnucleoside Inhibitors
NYANGUILE, Origene, PAUWELS, Frederik, DEHERTOGH, Pascale, CUMMINGS, Maxwell D, BONFANTI, Jean-Francois, SIMMEN, Kenneth A, RABOISSON, Pierre, VAN DEN BROECK, Walter, BOUTTON, Carlo W, QUIRYNEN, Ludo, IVENS, Tania, VAN DER HELM, Liesbet, VANDERCRUYSSEN, Geneviève, MOSTMANS, Wendy, DELOUVROY, Frédéric
Published in Antimicrobial Agents and Chemotherapy (01.12.2008)
Published in Antimicrobial Agents and Chemotherapy (01.12.2008)
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Discovery and Early Development of TMC647055, a Non-Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase
Cummings, Maxwell D., Lin, Tse-I, Hu, Lili, Tahri, Abdellah, McGowan, David, Amssoms, Katie, Last, Stefaan, Devogelaere, Benoit, Rouan, Marie-Claude, Vijgen, Leen, Berke, Jan Martin, Dehertogh, Pascale, Fransen, Els, Cleiren, Erna, van der Helm, Liesbet, Fanning, Gregory, Nyanguile, Origène, Simmen, Kenny, Van Remoortere, Pieter, Raboisson, Pierre, Vendeville, Sandrine
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055
Vendeville, Sandrine, Lin, Tse-I., Hu, Lili, Tahri, Abdellah, McGowan, David, Cummings, Maxwell D., Amssoms, Katie, Canard, Maxime, Last, Stefaan, Van den Steen, Iris, Devogelaere, Benoit, Rouan, Marie-Claude, Vijgen, Leen, Berke, Jan Martin, Dehertogh, Pascale, Fransen, Els, Cleiren, Erna, van der Helm, Liesbet, Fanning, Gregory, Van Emelen, Kristof, Nyanguile, Origène, Simmen, Kenny, Raboisson, Pierre
Published in Bioorganic & medicinal chemistry letters (01.07.2012)
Published in Bioorganic & medicinal chemistry letters (01.07.2012)
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Journal Article
1,5-Benzodiazepine inhibitors of HCV NS5B polymerase
McGowan, David, Nyanguile, Origène, Cummings, Maxwell D., Vendeville, Sandrine, Vandyck, Koen, Van den Broeck, Walter, Boutton, Carlo W., De Bondt, Hendrik, Quirynen, Ludo, Amssoms, Katie, Bonfanti, Jean-François, Last, Stefaan, Rombauts, Klara, Tahri, Abdellah, Hu, Lili, Delouvroy, Frédéric, Vermeiren, Katrien, Vandercruyssen, Geneviève, Van der Helm, Liesbet, Cleiren, Erna, Mostmans, Wendy, Lory, Pedro, Pille, Geert, Van Emelen, Kristof, Fanning, Gregory, Pauwels, Frederik, Lin, Tse-I, Simmen, Kenneth, Raboisson, Pierre
Published in Bioorganic & medicinal chemistry letters (01.05.2009)
Published in Bioorganic & medicinal chemistry letters (01.05.2009)
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Isolation and expression of novel human glutamate carboxypeptidases with N-acetylated alpha-linked acidic dipeptidase and dipeptidyl peptidase IV activity
Pangalos, M N, Neefs, J M, Somers, M, Verhasselt, P, Bekkers, M, van der Helm, L, Fraiponts, E, Ashton, D, Gordon, R D
Published in The Journal of biological chemistry (26.03.1999)
Published in The Journal of biological chemistry (26.03.1999)
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Journal Article
Structure-Based Macrocyclization Yields Hepatitis C Virus NS5B Inhibitors with Improved Binding Affinities and Pharmacokinetic Properties
Cummings, Maxwell D., Lin, Tse-I, Hu, Lili, Tahri, Abdellah, McGowan, David, Amssoms, Katie, Last, Stefaan, Devogelaere, Benoit, Rouan, Marie-Claude, Vijgen, Leen, Berke, Jan Martin, Dehertogh, Pascale, Fransen, Els, Cleiren, Erna, van der Helm, Liesbet, Fanning, Gregory, Van Emelen, Kristof, Nyanguile, Origène, Simmen, Kenny, Raboisson, Pierre, Vendeville, Sandrine
Published in Angewandte Chemie (07.05.2012)
Published in Angewandte Chemie (07.05.2012)
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Isolation and Expression of Novel Human Glutamate Carboxypeptidases with N-Acetylated α-Linked Acidic Dipeptidase and Dipeptidyl Peptidase IV Activity
Menelas N. Pangalos, Jean-Marc Neefs, Marijke Somers, Peter Verhasselt, Mariette Bekkers, Liesbet van der Helm, Erwin Fraiponts, David Ashton, Robert D. Gordon
Published in The Journal of biological chemistry (26.03.1999)
Published in The Journal of biological chemistry (26.03.1999)
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Enovin, a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. Existence and tissue-specific expression of different splice variants
Masure, S, Geerts, H, Cik, M, Hoefnagel, E, Van Den Kieboom, G, Tuytelaars, A, Harris, S, Lesage, A S, Leysen, J E, Van Der Helm, L, Verhasselt, P, Yon, J, Gordon, R D
Published in European journal of biochemistry (01.12.1999)
Published in European journal of biochemistry (01.12.1999)
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Enovin, a member of the glial cell‐line‐derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells
Masure, Stefan, Geerts, Hugo, Cik, Miroslav, Hoefnagel, Evert, Van Den Kieboom, Gerd, Tuytelaars, An, Harris, Sarah, Lesage, Anne S. J., Leysen, Josee E., van der Helm, Liesbet, Verhasselt, Peter, Yon, Jeff, Gordon, Robert D.
Published in European journal of biochemistry (01.12.1999)
Published in European journal of biochemistry (01.12.1999)
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