Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Modeling of Filgotinib (GLPG0634), a Selective JAK1 Inhibitor, in Support of Phase IIB Dose Selection
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Published in Clinical pharmacokinetics (01.08.2015)
Published in Clinical pharmacokinetics (01.08.2015)
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Safety, pharmacokinetics and pharmacodynamics of GLPG0974, a potent and selective FFA2 antagonist, in healthy male subjects
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Published in British journal of clinical pharmacology (01.07.2016)
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188 Exploration of GLPG0634, the First Selective JAK1 Inhibitor, in Inflammatory Bowel Disease Is Supported by Early Clinical Results and Mouse DSS-Colitis Data
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Development of an implantable infusion pump for sustained anti-HIV drug administration
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Published in International journal of pharmaceutics (01.05.2008)
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Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases
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Published in The Journal of immunology (1950) (01.10.2013)
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The influence of cisapride and clarithromycin on QT intervals in healthy volunteers
van Haarst, A D, van 't Klooster, G A, van Gerven, J M, Schoemaker, R C, van Oene, J C, Burggraaf, J, Coene, M C, Cohen, A F
Published in Clinical pharmacology and therapeutics (01.11.1998)
Published in Clinical pharmacology and therapeutics (01.11.1998)
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An open-label assessment of TMC 125: a new, next-generation NNRTI, for 7 days in HIV-1 infected individuals with NNRTI resistance
GAZZARD, Brian G, POZNIAK, Anton L, VANT'KLOOSTER, Gerben A. E, ROSENBAUM, Willy, YENI, G. Patrick, STASZEWSKI, Schlomo, ARASTEH, Keikawus, DE DIER, Karin, PEETERS, Monika, WOODFALL, Brian, STEBBING, Justin
Published in AIDS (London) (05.12.2003)
Published in AIDS (London) (05.12.2003)
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Correlations between factors determining the pharmacokinetics and antiviral activity of HIV-1 non-nucleoside reverse transcriptase inhibitors of the diaryltriazine and diarylpyrimidine classes of compounds
Lewi, Paul, Arnold, Eddy, Andries, Koen, Bohets, Hilde, Borghys, Herman, Clark, Arthur, Daeyaert, Frits, Das, Kalyan, de Béthune, Marie-Pierre, de Jonge, Marc, Heeres, Jan, Koymans, Luc, Leempoels, Jos, Peeters, Jef, Timmerman, Philip, Van den Broeck, Walter, Vanhoutte, Frédéric, Van't Klooster, Gerben, Vinkers, Maarten, Volovik, Yulia, Janssen, Paul A J
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Published in Drugs in R&D (2004)
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Inulin solid dispersion technology to improve the absorption of the BCS Class IV drug TMC240
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Published in European journal of pharmaceutics and biopharmaceutics (01.02.2010)
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Clinical Confirmation that the Selective JAK1 Inhibitor Filgotinib (GLPG0634) has a Low Liability for Drug-drug Interactions
Namour, Florence, Desrivot, Julie, Van der Aa, Annegret, Harrison, Pille, Tasset, Chantal, van't Klooster, Gerben
Published in Drug metabolism letters (2016)
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Published in Drug metabolism letters (2016)
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A randomized, double-blind, placebo-controlled trial of TMC125 as 7-day monotherapy in antiretroviral naive, HIV-1 infected subjects
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Published in AIDS (London) (21.11.2003)
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Co-administration of darunavir and a new pharmacokinetic booster: Formulation strategies and evaluation in dogs
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Published in European journal of pharmaceutical sciences (09.10.2010)
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TMC125 exerts similar initial antiviral potency as a five-drug, triple class antiretroviral regimen
SANKATSING, Sanjay U. C, WEVERLING, Gerrit J, PEETERS, Monika, VAN'T KLOOSTER, Gerben, GRUZDEV, Boris, RAKHMANOVA, Aza, DANNER, Sven A, JURRIAANS, Suzanne, PRINS, Jan M, LANGE, Joep M. A
Published in AIDS (London) (05.12.2003)
Published in AIDS (London) (05.12.2003)
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Cytochrome P450 induction and metabolism of alkoxyresorufins, ethylmorphine and testosterone in cultured hepatocytes from goats, sheep and cattle
van't Klooster, Gerben A.E., Blaauboer, Bas J., Noordhoek, Jan, van Miert, Adelbert S.J.P.A.M.
Published in Biochemical pharmacology (17.11.1993)
Published in Biochemical pharmacology (17.11.1993)
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METHODS FOR THE TREATMENT OF CARDIOVASCULAR DISORDERS
VAN'T KLOOSTER, Gerben, Albert, Eleutherius, WIGERINCK, Piet, Tom, Bert, Paul
Year of Publication 11.01.2019
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Year of Publication 11.01.2019
Patent
Uso de compuestos aminotriazolopiridinas sustituidos, en el tratamiento de afecciones inflamatorias, autoinmunitarias, proliferativas, alergias, rechazo de trasplantes, entre otras; composicion farmaceutica que los comprende; combinacion farmaceutica
BRYS, REGINALD CHRISTOPHE XAVIER, VAN ROMPAEY, LUC JULIAAN CORINA, NAMOUR, FLORENCE SYLVIE, VAN'T KLOOSTER, GERBEN ALBERT ELEUTHERIUS
Year of Publication 27.02.2015
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Year of Publication 27.02.2015
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Induction of hepatic drug metabolizing enzymes and interaction with carbon tetrachloride in rats after a single oral exposure to atrazine
Ugazio, Giancarlo, Burdino, Elisa, Dacasto, Mauro, Bosio, Anita, van't Klooster, Gerben, Nebbia, Carlo
Published in Toxicology letters (01.09.1993)
Published in Toxicology letters (01.09.1993)
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Hepatic cytochrome P450 induction in goats: Effects of model inducers on the metabolism of alkoxyresorufins, testosterone and ethylmorphine, and on apoprotein and mRNA levels
Van't Klooster, Gerben A.E., Horbach, G.J.M.Jean, Natsuhori, Masahiro, Blaauboer, Bas J., Noordhoek, Jan, Van Miert, Adelbert S.J.P.A.M.
Published in Biochemical pharmacology (07.01.1993)
Published in Biochemical pharmacology (07.01.1993)
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Hepatic cytochrome P450 induction in goats
Van't Klooster, Gerben A.E., Horbach, G.J.M.Jean, Natsuhori, Masahiro, Blaauboer, Bas J., Noordhoek, Jan, Van Miert, Adelbert S.J.P.A.M.
Published in Biochemical pharmacology (01.01.1993)
Published in Biochemical pharmacology (01.01.1993)
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