Drug Repurposing Using Deep Embeddings of Gene Expression Profiles
Donner, Yoni, Kazmierczak, Stéphane, Fortney, Kristen
Published in Molecular pharmaceutics (01.10.2018)
Published in Molecular pharmaceutics (01.10.2018)
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Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19
Wong, Lok-Yin Roy, Zheng, Jian, Wilhelmsen, Kevin, Li, Kun, Ortiz, Miguel E., Schnicker, Nicholas J., Thurman, Andrew, Pezzulo, Alejandro A., Szachowicz, Peter J., Li, Pengfei, Pan, Ruangang, Klumpp, Klaus, Aswad, Fred, Rebo, Justin, Narumiya, Shuh, Murakami, Makoto, Zuniga, Sonia, Sola, Isabel, Enjuanes, Luis, Meyerholz, David K., Fortney, Kristen, McCray, Paul B., Perlman, Stanley
Published in Nature (London) (05.05.2022)
Published in Nature (London) (05.05.2022)
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Network-based characterization of drug-regulated genes, drug targets, and toxicity
Kotlyar, Max, Fortney, Kristen, Jurisica, Igor
Published in Methods (San Diego, Calif.) (01.08.2012)
Published in Methods (San Diego, Calif.) (01.08.2012)
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Journal Article
Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity
Fortney, Kristen, Dobriban, Edgar, Garagnani, Paolo, Pirazzini, Chiara, Monti, Daniela, Mari, Daniela, Atzmon, Gil, Barzilai, Nir, Franceschi, Claudio, Owen, Art B, Kim, Stuart K
Published in PLoS genetics (01.12.2015)
Published in PLoS genetics (01.12.2015)
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118-OR: The Apelin Receptor Agonist Azelaprag Increases Weight Loss in Diet-Induced Obese Mice on Incretin Agonists and Restores Body Composition and Muscle Function to That of Lean Controls
Wang, Yan, Yan, Shijun, Banicki, Matthew, Cochran, Mary, Portillo, Claudia, Guerrero, Gabriel, Pan, Yong, Cowdin, Samantha, Patil, Christopher, Rebo, Justin, Hughes, Robert, Montgomery, Rusty, Morgen, Eric, tney, Kristen, Rubin, Paul
Published in Diabetes (New York, N.Y.) (01.06.2024)
Published in Diabetes (New York, N.Y.) (01.06.2024)
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The prostaglandin D2 antagonist asapiprant ameliorates clinical severity in young hosts infected with invasive Streptococcus pneumoniae
Bhalla, Manmeet, Herring, Sydney, Lenhard, Alexsandra, Wheeler, Joshua R, Aswad, Fred, Klumpp, Klaus, Rebo, Justin, Wang, Yan, Wilhelmsen, Kevin, Fortney, Kristen, Bou Ghanem, Elsa N
Published in Infection and immunity (07.05.2024)
Published in Infection and immunity (07.05.2024)
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Journal Article
Validation of biomarkers of aging
Moqri, Mahdi, Herzog, Chiara, Poganik, Jesse R., Ying, Kejun, Justice, Jamie N., Belsky, Daniel W., Higgins-Chen, Albert T., Chen, Brian H., Cohen, Alan A., Fuellen, Georg, Hägg, Sara, Marioni, Riccardo E., Widschwendter, Martin, Fortney, Kristen, Fedichev, Peter O., Zhavoronkov, Alex, Barzilai, Nir, Lasky-Su, Jessica, Kiel, Douglas P., Kennedy, Brian K., Cummings, Steven, Slagboom, P. Eline, Verdin, Eric, Maier, Andrea B., Sebastiano, Vittorio, Snyder, Michael P., Gladyshev, Vadim N., Horvath, Steve, Ferrucci, Luigi
Published in Nature medicine (01.02.2024)
Published in Nature medicine (01.02.2024)
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The discovery of novel and potent indazole NLRP3 inhibitors enabled by DNA-encoded library screening
Hartman, George, Humphries, Paul, Hughes, Robert, Ho, Andrew, Montgomery, Rusty, Deshpande, Aditi, Mahanta, Maitriyee, Tronnes, Sarah, Cowdin, Samantha, He, Xu, Liu, Fangchao, Zhang, Lifang, Liu, Chuan, Dou, Dengfeng, Li, Jin, Spasic, Aleksander, Coll, Rebecca, Marleaux, Michael, Hochheiser, Inga V., Geyer, Matthias, Rubin, Paul, Fortney, Kristen, Wilhelmsen, Kevin
Published in Bioorganic & medicinal chemistry letters (01.04.2024)
Published in Bioorganic & medicinal chemistry letters (01.04.2024)
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Journal Article
Circulating glucuronic acid predicts healthspan and longevity in humans and mice
Ho, Andrew, Sinick, Jonah, Esko, Tõnu, Fischer, Krista, Menni, Cristina, Zierer, Jonas, Matey-Hernandez, Maria, Fortney, Kristen, Morgen, Eric K
Published in Aging (Albany, NY.) (26.09.2019)
Published in Aging (Albany, NY.) (26.09.2019)
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Journal Article
Defining a longevity biotechnology company
Boekstein, Nicola, Barzilai, Nir, Bertram, André, Betts-LaCroix, Joe, Fortney, Kristen, Helliwell, Stephen B., Hufford, Michael, Mannick, Joan, McLaughlin, Jerry, Mellon, Jim, Morgen, Eric, Regge, Nils, Robinton, Daisy A., Sinclair, David A., Young, Sergey, Starr, Risa, Zhavoronkov, Alex, Peyer, James
Published in Nature biotechnology (01.08.2023)
Published in Nature biotechnology (01.08.2023)
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Integrating untargeted metabolomics, genetically informed causal inference, and pathway enrichment to define the obesity metabolome
Hsu, Yu-Han H., Astley, Christina M., Cole, Joanne B., Vedantam, Sailaja, Mercader, Josep M., Metspalu, Andres, Fischer, Krista, Fortney, Kristen, Morgen, Eric K., Gonzalez, Clicerio, Gonzalez, Maria E., Esko, Tonu, Hirschhorn, Joel N.
Published in International Journal of Obesity (01.07.2020)
Published in International Journal of Obesity (01.07.2020)
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Journal Article
Prioritizing therapeutics for lung cancer: an integrative meta-analysis of cancer gene signatures and chemogenomic data
Fortney, Kristen, Griesman, Joshua, Kotlyar, Max, Pastrello, Chiara, Angeli, Marc, Sound-Tsao, Ming, Jurisica, Igor
Published in PLoS computational biology (01.03.2015)
Published in PLoS computational biology (01.03.2015)
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Journal Article
Whole-genome sequencing of the world's oldest people
Gierman, Hinco J, Fortney, Kristen, Roach, Jared C, Coles, Natalie S, Li, Hong, Glusman, Gustavo, Markov, Glenn J, Smith, Justin D, Hood, Leroy, Coles, L Stephen, Kim, Stuart K
Published in PloS one (12.11.2014)
Published in PloS one (12.11.2014)
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Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity
Lyu, Yu-Xuan, Fu, Qiang, Wilczok, Dominika, Ying, Kejun, King, Aaron, Antebi, Adam, Vojta, Aleksandar, Stolzing, Alexandra, Moskalev, Alexey, Georgievskaya, Anastasia, Maier, Andrea B, Olsen, Andrea, Groth, Anja, Simon, Anna Katharina, Brunet, Anne, Jamil, Aisyah, Kulaga, Anton, Bhatti, Asif, Yaden, Benjamin, Pedersen, Bente Klarlund, Schumacher, Björn, Djordjevic, Boris, Kennedy, Brian, Chen, Chieh, Huang, Christine Yuan, Correll, Christoph U, Murphy, Coleen T, Ewald, Collin Y, Chen, Danica, Valenzano, Dario Riccardo, Sołdacki, Dariusz, Erritzoe, David, Meyer, David, Sinclair, David A, Chini, Eduardo Nunes, Teeling, Emma C, Morgen, Eric, Verdin, Eric, Vernet, Erik, Pinilla, Estefano, Fang, Evandro F, Bischof, Evelyne, Mercken, Evi M, Finger, Fabian, Kuipers, Folkert, Pun, Frank W, Gyülveszi, Gabor, Civiletto, Gabriele, Zmudze, Garri, Blander, Gil, Pincus, Harold A, McClure, Joshua, Kirkland, James L, Peyer, James, Justice, Jamie N, Vijg, Jan, Gruhn, Jennifer R, McLaughlin, Jerry, Mannick, Joan, Passos, João, Baur, Joseph A, Betts-LaCroix, Joe, Sedivy, John M, Speakman, John R, Shlain, Jordan, von Maltzahn, Julia, Andreasson, Katrin I, Moody, Kelsey, Palikaras, Konstantinos, Fortney, Kristen, Niedernhofer, Laura J, Rasmussen, Lene Juel, Veenhoff, Liesbeth M, Melton, Lisa, Ferrucci, Luigi, Quarta, Marco, Koval, Maria, Marinova, Maria, Hamalainen, Mark, Unfried, Maximilian, Ringel, Michael S, Filipovic, Milos, Topors, Mourad, Mitin, Natalia, Roy, Nawal, Pintar, Nika, Barzilai, Nir, Binetti, Paolo, Singh, Parminder, Kohlhaas, Paul, Robbins, Paul D, Rubin, Paul, Fedichev, Peter O, Kamya, Petrina, Muñoz-Canoves, Pura, de Cabo, Rafael, Faragher, Richard G A, Konrad, Rob, Ripa, Roberto, Mansukhani, Robin
Published in Aging (Albany, NY.) (16.10.2024)
Published in Aging (Albany, NY.) (16.10.2024)
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NetwoRx: connecting drugs to networks and phenotypes in Saccharomyces cerevisiae
Fortney, Kristen, Xie, Wing, Kotlyar, Max, Griesman, Joshua, Kotseruba, Yulia, Jurisica, Igor
Published in Nucleic acids research (01.01.2013)
Published in Nucleic acids research (01.01.2013)
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