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Single-Dose Pharmacokinetics and Pharmacodynamics of Transthyretin Targeting N-acetylgalactosamine-Small Interfering Ribonucleic Acid Conjugate, Vutrisiran, in Healthy Subjects
Habtemariam, Bahru A, Karsten, Verena, Attarwala, Husain, Goel, Varun, Melch, Megan, Clausen, Valerie A, Garg, Pushkal, Vaishnaw, Akshay K, Sweetser, Marianne T, Robbie, Gabriel J, Vest, John
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Published in Clinical pharmacology and therapeutics (01.02.2021)
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Phase I study of [68Ga]Ga-HX01 for targeting integrin αvβ3 and CD13 in healthy and malignancy subjects
Zhang, Xiao, Fang, Hanyi, Yang, Biao, Qin, Chunxia, Hu, Fan, Ruan, Weiwei, Chen, Jing, Zeng, Dexing, Gai, Yongkang, Lan, Xiaoli
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Published in European journal of nuclear medicine and molecular imaging (01.03.2025)
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Therapeutic Targeting of Signaling Pathways Related to Cancer Stemness
Asunción Espinosa-Sánchez, Elisa Suárez-Martínez, Laura Sánchez-Díaz, Amancio Carnero
Published in Frontiers in Oncology (26.08.2020)
Published in Frontiers in Oncology (26.08.2020)
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Targeting brain regions of interest in functional near‐infrared spectroscopy—Scalp‐cortex correlation using subject‐specific light propagation models
Cai, Lin, Nitta, Tomonori, Yokota, Sho, Obata, Takayuki, Okada, Eiji, Kawaguchi, Hiroshi
Published in Human brain mapping (01.05.2021)
Published in Human brain mapping (01.05.2021)
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Targeting Mitochondria in Diabetes
Krako Jakovljevic, Nina, Pavlovic, Kasja, Jotic, Aleksandra, Lalic, Katarina, Stoiljkovic, Milica, Lukic, Ljiljana, Milicic, Tanja, Macesic, Marija, Stanarcic Gajovic, Jelena, Lalic, Nebojsa M.
Published in International journal of molecular sciences (21.06.2021)
Published in International journal of molecular sciences (21.06.2021)
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TSH receptor specific monoclonal autoantibody K1‐70TM targeting of the TSH receptor in subjects with Graves' disease and Graves' orbitopathy—Results from a phase I clinical trial
Furmaniak, Jadwiga, Sanders, Jane, Sanders, Paul, Li, Yang, Rees Smith, Bernard
Published in Clinical endocrinology (Oxford) (01.06.2022)
Published in Clinical endocrinology (Oxford) (01.06.2022)
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Pharmacokinetics and Pharmacodynamics of JNJ-55920839, an Antibody Targeting Interferon α/ω, in Healthy Subjects and Subjects with Mild-to-Moderate Systemic Lupus Erythematosus
Yao, Zhenling, Loggia, Laura, Fink, Damien, Chevrier, Marc, Marciniak, Stanley, Sharma, Amarnath, Xu, Zhenhua
Published in Clinical drug investigation (01.12.2020)
Published in Clinical drug investigation (01.12.2020)
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Pharmacokinetics and Safety Profile of SNS812, a First in Human Fully Modified siRNA Targeting Wide‐Spectrum SARS‐CoV‐2, in Healthy Subjects
Chang, Yi‐Chung, Chen, Yi‐Fen, Yang, Chi‐Fan, Ho, Hui‐Ju, Yang, Jen Fu, Chou, Yuan‐Lin, Lin, Ching‐Wen, Yang, Pan‐Chyr
Published in Clinical and translational science (01.03.2025)
Published in Clinical and translational science (01.03.2025)
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First-in-human phase I study of ISTH0036, an antisense oligonucleotide selectively targeting transforming growth factor beta 2 (TGF-β2), in subjects with open-angle glaucoma undergoing glaucoma filtration surgery
Pfeiffer, Norbert, Voykov, Bogomil, Renieri, Giulia, Bell, Katharina, Richter, Paul, Weigel, Melanie, Thieme, Hagen, Wilhelm, Barbara, Lorenz, Katrin, Feindor, Martin, Wosikowski, Katja, Janicot, Michel, Päckert, Daniela, Römmich, Regina, Mala, Carola, Fettes, Petra, Leo, Eugen
Published in PloS one (30.11.2017)
Published in PloS one (30.11.2017)
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Novel Approach Targeting the Complex Pathophysiology of Hypertrophic Cardiomyopathy: The Impact of Late Sodium Current Inhibition on Exercise Capacity in Subjects with Symptomatic Hypertrophic Cardiomyopathy (LIBERTY-HCM) Trial
Olivotto, Iacopo, Hellawell, Jennifer L., Farzaneh-Far, Ramin, Blair, Christiana, Coppini, Raffaele, Myers, Jonathan, Belardinelli, Luiz, Maron, Martin S.
Published in Circulation. Heart failure (01.03.2016)
Published in Circulation. Heart failure (01.03.2016)
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Cell-Penetrating Pepducin Therapy Targeting PAR1 in Subjects With Coronary Artery Disease
Gurbel, Paul A., Bliden, Kevin P., Turner, Susan E., Tantry, Udaya S., Gesheff, Martin G., Barr, Travis P., Covic, Lidija, Kuliopulos, Athan
Published in Arteriosclerosis, thrombosis, and vascular biology (01.01.2016)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.01.2016)
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IL-33 promotes food anaphylaxis in epicutaneously sensitized mice by targeting mast cells
Galand, Claire, Leyva-Castillo, Juan Manuel, Yoon, Juhan, Han, Alex, Lee, Margaret S., McKenzie, Andrew N.J., Stassen, Michael, Oyoshi, Michiko K., Finkelman, Fred D., Geha, Raif S.
Published in Journal of allergy and clinical immunology (01.11.2016)
Published in Journal of allergy and clinical immunology (01.11.2016)
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Pharmacokinetic and Pharmacodynamic Properties of Cemdisiran, an RNAi Therapeutic Targeting Complement Component 5, in Healthy Subjects and Patients with Paroxysmal Nocturnal Hemoglobinuria
Badri, Prajakta, Jiang, Xuemin, Borodovsky, Anna, Najafian, Nader, Kim, Jae, Clausen, Valerie A., Goel, Varun, Habtemariam, Bahru, Robbie, Gabriel J.
Published in Clinical pharmacokinetics (01.03.2021)
Published in Clinical pharmacokinetics (01.03.2021)
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53019 Efficacy and tolerability of a face serum targeting healthy aging in subjects with sensitive skin
Pellacani, Giovanni, Grivet-Seyve, Mathieu, Le Noel, Virginie, Piotrowski, Krzysztof, Lachmann, Nadège
Published in Journal of the American Academy of Dermatology (01.09.2024)
Published in Journal of the American Academy of Dermatology (01.09.2024)
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Repetitive transcranial magnetic stimulation targeting the insular cortex for reduction of heavy drinking in treatment-seeking alcohol-dependent subjects: a randomized controlled trial
Perini, Irene, Kämpe, Robin, Arlestig, Theodor, Karlsson, Hanna, Löfberg, Andreas, Pietrzak, Michal, Zangen, Abraham, Heilig, Markus
Published in Neuropsychopharmacology (New York, N.Y.) (01.04.2020)
Published in Neuropsychopharmacology (New York, N.Y.) (01.04.2020)
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Improved glycemic control with minimal systemic metformin exposure: Effects of Metformin Delayed-Release (Metformin DR) targeting the lower bowel over 16 weeks in a randomized trial in subjects with type 2 diabetes
Henry, Robert R., Frias, Juan P., Walsh, Brandon, Skare, Sharon, Hemming, John, Burns, Colleen, Bicsak, Thomas A., Baron, Alain, Fineman, Mark
Published in PloS one (25.09.2018)
Published in PloS one (25.09.2018)
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Estrogen supplementation deteriorates visceral adipose function in aged postmenopausal subjects via Gas5 targeting IGF2BP1
Lv, Yifan, Wang, Fengliang, Sheng, Yunlu, Xia, Fan, Jin, Yi, Ding, Guoxian, Wang, Xiaodong, Yu, Jing
Published in Experimental gerontology (15.06.2022)
Published in Experimental gerontology (15.06.2022)
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Mavrilimumab, a human monoclonal antibody targeting GM-CSF receptor-α, in subjects with rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase I, first-in-human study
Burmester, Gerd R, Feist, Eugen, Sleeman, Matthew A, Wang, Bing, White, Barbara, Magrini, Fabio
Published in Annals of the rheumatic diseases (01.09.2011)
Published in Annals of the rheumatic diseases (01.09.2011)
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Targeting hypoxia in solid and haematological malignancies
Harris, Bill, Saleem, Sana, Cook, Natalie, Searle, Emma
Published in Journal of experimental & clinical cancer research (02.11.2022)
Published in Journal of experimental & clinical cancer research (02.11.2022)
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