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Small-molecule–induced DNA damage identifies alternative DNA structures in human genes
Rodriguez, Raphaël, Miller, Kyle M, Forment, Josep V, Bradshaw, Charles R, Nikan, Mehran, Britton, Sébastien, Oelschlaegel, Tobias, Xhemalce, Blerta, Balasubramanian, Shankar, Jackson, Stephen P
Published in Nature chemical biology (01.03.2012)
Published in Nature chemical biology (01.03.2012)
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Small molecule metabolites: discovery of biomarkers and therapeutic targets
Qiu, Shi, Cai, Ying, Yao, Hong, Lin, Chunsheng, Xie, Yiqiang, Tang, Songqi, Zhang, Aihua
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Published in Signal transduction and targeted therapy (20.03.2023)
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95-LB: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Novel Oral Small Molecule GLP-1 Receptor Agonist (HRS-7535) in Healthy Subjects —A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single- and Multiple-Ascending Dose Study
WU, JINGYING, HU, WEI, DU, YIJUN, ZHANG, QIAN, ZHOU, RENPENG, ZHANG, QIN, QIN, HUILING, YE, ZI, XU, YIMEI, FENG, SHENG, SHU, CHANG, SHEN, YU, FAN, YANG
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Published in Diabetes (New York, N.Y.) (20.06.2023)
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1983-LB: A Phase 1 Study of ID110521156, a Small Molecule Glucagon-Like Peptide 1 Receptor Agonist, in Healthy Subjects
JE, IN-GYU, KYOUNG, YU-JUNG, YOO, SUN-HOO, HONG, EUN-HYUNG, KIM, MINCHEOL, YANG, JI-YOUNG, WON, HEEJAE, LEE, SEUNGHWAN, PARK, JOONTAE
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Published in Diabetes (New York, N.Y.) (20.06.2025)
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First‐in‐human study to assess the safety, pharmacokinetics and pharmacodynamics of BMS‐962212, a direct, reversible, small molecule factor XIa inhibitor in non‐Japanese and Japanese healthy subjects
Perera, Vidya, Luettgen, Joseph M., Wang, Zhaoqing, Frost, Charles E., Yones, Cynthia, Russo, Cesare, Lee, John, Zhao, Yue, LaCreta, Frank P., Ma, Xuewen, Knabb, Robert M., Seiffert, Dietmar, DeSouza, Mary, Mugnier, Pierre, Cirincione, Brenda, Ueno, Takayo, Frost, Robert J. A.
Published in British Journal of Clinical Pharmacology (01.05.2018)
Published in British Journal of Clinical Pharmacology (01.05.2018)
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A versatile small-molecule fluorescence scaffold: Carbazole derivatives for bioimaging
Yin, Junling, Ma, Yanyan, Li, Guanghan, Peng, Min, Lin, Weiying
Published in Coordination chemistry reviews (01.06.2020)
Published in Coordination chemistry reviews (01.06.2020)
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99mTc-labeled small-molecule inhibitors of prostate-specific membrane antigen: pharmacokinetics and biodistribution studies in healthy subjects and patients with metastatic prostate cancer
Vallabhajosula, Shankar, Nikolopoulou, Anastasia, Babich, John W, Osborne, Joseph R, Tagawa, Scott T, Lipai, Irina, Solnes, Lilja, Maresca, Kevin P, Armor, Thomas, Joyal, John L, Crummet, Robert, Stubbs, James B, Goldsmith, Stanley J
Published in The Journal of nuclear medicine (1978) (01.11.2014)
Published in The Journal of nuclear medicine (1978) (01.11.2014)
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THU-248 Preliminary safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple doses of AB-101, a small-molecule PD-L1 inhibitor, in healthy and chronic hepatitis B subjects
Gane, Edward J., Dobryanska, Marta, Jucov, Alina, Yuen, Man-Fung, Wong, Grace Lai-Hung, Thi, Emily P., Eley, Timothy, Ganchua, Sharie C., Espiritu, Christine L., Sharma, Varun, Pamulapati, Reddy, Cole, Andrew G., Heffernan, Gavin D., Ozturk, Seyma, Lam, Angela M., Harasym, Troy O., Dugyala, Ravi, Sofia, Michael J., Sims, Karen D., Varughese, Tilly
Published in Journal of hepatology (01.05.2025)
Published in Journal of hepatology (01.05.2025)
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Structural features of the protein kinase domain and targeted binding by small-molecule inhibitors
Arter, Chris, Trask, Luke, Ward, Sarah, Yeoh, Sharon, Bayliss, Richard
Published in The Journal of biological chemistry (01.08.2022)
Published in The Journal of biological chemistry (01.08.2022)
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KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington’s disease patients
Quinti, Luisa, Naidu, Sharadha Dayalan, Träger, Ulrike, Chen, Xiqun, Kegel-Gleason, Kimberly, Llères, David, Connolly, Colúm, Chopra, Vanita, Low, Cho, Moniot, Sébastien, Sapp, Ellen, Tousley, Adelaide R., Vodicka, Petr, Van Kanegan, Michael J., Kaltenbach, Linda S., Crawford, Lisa A., Fuszard, Matthew, Higgins, Maureen, Miller, James R. C., Farmer, Ruth E., Potluri, Vijay, Samajdar, Susanta, Meisel, Lisa, Zhang, Ningzhe, Snyder, Andrew, Stein, Ross, Hersch, Steven M., Ellerby, Lisa M., Weerapana, Eranthie, Schwarzschild, Michael A., Steegborn, Clemens, Leavitt, Blair R., Degterev, Alexei, Tabrizi, Sarah J., Lo, Donald C., DiFiglia, Marian, Thompson, Leslie M., Dinkova-Kostova, Albena T., Kazantsev, Aleksey G.
Published in Proceedings of the National Academy of Sciences - PNAS (06.06.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (06.06.2017)
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Identification of small molecule antagonists of sonic hedgehog/heparin binding with activity in hedgehog functional assays
Lamson, David R., Tarpley, Michael, Addo, Kezia, Ji, Xiaojia, Abu Rabe, Dina, Ehe, Ben, Hughes, Mark, Smith, Ginger R., Daye, Laura R., Musso, David L., Zheng, Weifan, Williams, Kevin P.
Published in Biochimica et biophysica acta. General subjects (01.11.2024)
Published in Biochimica et biophysica acta. General subjects (01.11.2024)
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Phase 1b/2a study of PLX2853, a small molecule BET inhibitor, in subjects with advanced solid tumors and lymphoma
Gordon, Michael S., Carvajal, Richard D., Spira, Alexander I., Huang, Marilyn, Watkins, Paul, Powell, Ben, Inokuchi, Kerry, Sterba, Michael, Matusow, Bernice, Hope, Chelsea, Halladay, Jason, Zhang, Chao, Walling, Jacqueline M., Tsiatis, Athanasios C., Patnaik, Amita
Published in Journal of clinical oncology (20.05.2021)
Published in Journal of clinical oncology (20.05.2021)
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724-P: A First-in-Human Study of RGT-075, a Novel, Orally Bioavailable, Small-Molecule GLP-1 Receptor Agonist, in Healthy Adult Subjects
PIRNER, MARK A., LIN, JING, LIU, FENG, YAO, LILI, ZETTLER, MARJORIE E., VALACER, DAVID J.
Published in Diabetes (New York, N.Y.) (01.06.2022)
Published in Diabetes (New York, N.Y.) (01.06.2022)
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First-In-Human Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of SHR2285, a Small-Molecule Factor XIa Inhibitor in Healthy Subjects
Chen, Rui, Guan, Xiaoduo, Hu, Pei, Dong, Yanli, Zhu, Yi, Zhang, Tengfei, Zou, Jianjun, Zhang, Shuyang
Published in Frontiers in pharmacology (10.02.2022)
Published in Frontiers in pharmacology (10.02.2022)
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Comparative Efficacy of Biologics and Small Molecule in Ulcerative Colitis: A Systematic Review and Network Meta-analysis
Shehab, Mohammad, Alrashed, Fatema, Alsayegh, Abdulwahab, Aldallal, Usama, Ma, Christopher, Narula, Neeraj, Jairath, Vipul, Singh, Siddharth, Bessissow, Talat
Published in Clinical gastroenterology and hepatology (01.02.2025)
Published in Clinical gastroenterology and hepatology (01.02.2025)
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Safety, Tolerability, and Pharmacokinetics of SC1011 (Sufenidone), a Novel Antifibrotic Small Molecule, in Phase 1 Studies in Healthy Subjects
Liu, Yun, Chen, Xiaoning, Tang, Huimin, Jiang, Fan, Tang, Yaqin, Zhu, Huijuan, Du, Yanping, Qian, Hongjie, Liu, Shuyun, Sun, Xiaoshu, Zan, Bin, Zeng, Yuexia, Li, Yun, Ge, Zhen, Li, Yongguo, Yang, Zhongqi
Published in Clinical and translational science (01.03.2025)
Published in Clinical and translational science (01.03.2025)
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Small molecule ligands for α9 and α7 nicotinic receptors: A survey and an update, respectively
Giraudo, Alessandro, Pallavicini, Marco, Bolchi, Cristiano
Published in Pharmacological research (01.07.2023)
Published in Pharmacological research (01.07.2023)
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The small molecule indirubin-3′-oxime activates Wnt/β-catenin signaling and inhibits adipocyte differentiation and obesity
Choi, O M, Cho, Y-H, Choi, S, Lee, S-H, Seo, S H, Kim, H-Y, Han, G, Min, D S, Park, T, Choi, K Y
Published in International Journal of Obesity (01.08.2014)
Published in International Journal of Obesity (01.08.2014)
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Diagnostic value for methylation in cervical cancer based on a small‐molecule fluorescent probe targeting DNMT1
Yang, Baohua, Xu, Chao, Li, Hang, Zhu, Xiuxiang, Xia, Ziyin, Xu, Ling, Zhang, Qian
Published in Skin research and technology (01.09.2024)
Published in Skin research and technology (01.09.2024)
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