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A Placebo- and Midazolam-Controlled Phase I Single Ascending-Dose Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics of Remimazolam (CNS 7056): Part I. Safety, Efficacy, and Basic Pharmacokinetics
Antonik, Laurie J., Goldwater, D. Ronald, Kilpatrick, Gavin J., Tilbrook, Gary S., Borkett, Keith M.
Published in Anesthesia and analgesia (01.08.2012)
Published in Anesthesia and analgesia (01.08.2012)
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A Placebo- and Midazolam-Controlled Phase I Single Ascending-Dose Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics of Remimazolam (CNS 7056): Part II. Population Pharmacokinetic and Pharmacodynamic Modeling and Simulation
Wiltshire, Hugh R., Kilpatrick, Gavin J., Tilbrook, Gary S., Borkett, Keith M.
Published in Anesthesia and analgesia (01.08.2012)
Published in Anesthesia and analgesia (01.08.2012)
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A double‐blind, placebo‐controlled, single‐ascending dose study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of HM15136, a novel long‐acting glucagon analogue, in healthy subjects
Huh, Ki Young, Hwang, Jun Gi, Shin, Wonjung, BAEK, Seungjae, Choi, JaeDuk, Lee, Nora, Cho, Young Min, Lee, Howard
Published in Diabetes, obesity & metabolism (01.03.2022)
Published in Diabetes, obesity & metabolism (01.03.2022)
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A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects
Taylor, Lesley, Gidal, Barry, Blakey, Graham, Tayo, Bola, Morrison, Gilmour
Published in CNS drugs (01.11.2018)
Published in CNS drugs (01.11.2018)
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Safety, tolerability, and pharmacokinetics of a single ascending dose of baicalein chewable tablets in healthy subjects
Li, Min, Shi, Aixin, Pang, Hongxian, Xue, Wei, Li, Yang, Cao, Guoying, Yan, Bei, Dong, Fan, Li, Kexin, Xiao, Wei, He, Guorong, Du, Guanhua, Hu, Xin
Published in Journal of ethnopharmacology (28.10.2014)
Published in Journal of ethnopharmacology (28.10.2014)
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A Phase 1, Randomized, Single-Ascending-Dose Study To Investigate the Safety, Tolerability, and Pharmacokinetics of DSTA4637S, an Anti- Staphylococcus aureus Thiomab Antibody-Antibiotic Conjugate, in Healthy Volunteers
Peck, Melicent, Rothenberg, Michael E., Deng, Rong, Lewin-Koh, Nicholas, She, Gaohong, Kamath, Amrita V., Carrasco-Triguero, Montserrat, Saad, Ola, Castro, Aide, Teufel, Lisa, Dickerson, Daniel S., Leonardelli, Marisa, Tavel, Jorge A.
Published in Antimicrobial agents and chemotherapy (01.06.2019)
Published in Antimicrobial agents and chemotherapy (01.06.2019)
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Safety, pharmacokinetic and pharmacodynamic properties of single ascending dose and continuous infusion of remimazolam besylate in healthy Chinese volunteers
Sheng, Xiao-yan, Liang, Yan, Yang, Xue-yuan, Li, Li-e, Ye, Xia, Zhao, Xia, Cui, Yi-min
Published in European journal of clinical pharmacology (01.03.2020)
Published in European journal of clinical pharmacology (01.03.2020)
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1859-LB: PG-102, a Novel Bispecific GLP-1R/GLP-2R Fc-Fused Agonist—Data on Safety, Tolerability, and Pharmacokinetics (PK) in Single Ascending Dose Trial in Healthy Subjects and Preliminary Population PK Modeling
HAN, SEUNGHOON, HAN, SUNGPIL, SON, KYOUNG-HWA, SUNG, YOUNGCHUL
Published in Diabetes (New York, N.Y.) (14.06.2024)
Published in Diabetes (New York, N.Y.) (14.06.2024)
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Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Oral NLRP3 Inflammasome Inhibitor ZYIL1: First‐in‐Human Phase 1 Studies (Single Ascending Dose and Multiple Ascending Dose)
Parmar, Deven V., Kansagra, Kevinkumar A., Momin, Taufik, Patel, Hardik B., Jansari, Gaurav A., Bhavsar, Jay, Shah, Chintan, Patel, Jayesh M., Ghoghari, Ashok, Barot, Ajay, Sharma, Bhavesh, Viswanathan, Kasinath, Patel, Harilal V., Jain, Mukul R.
Published in Clinical pharmacology in drug development (01.02.2023)
Published in Clinical pharmacology in drug development (01.02.2023)
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Keverprazan, a novel potassium-competitive acid blocker: Single ascending dose safety, tolerability, pharmacokinetics, pharmacodynamics and food effect in healthy subjects
Zhou, Sufeng, Xie, Lijun, Zhou, Chen, Zhao, Yuqing, Wang, Lu, Ding, Sijia, Chen, Juan, Zhu, Bei, Su, Mei, Shao, Feng
Published in European journal of pharmaceutical sciences (01.11.2023)
Published in European journal of pharmaceutical sciences (01.11.2023)
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A Phase I, Randomized, Single‑Blind, Placebo‑Controlled, Single Ascending Dose Study of the Safety, Tolerability, and Pharmacokinetics of Subcutaneous and Oral TRV250, a G Protein-Selective Delta Receptor Agonist, in Healthy Subjects
Fossler, Michael J., Schmith, Virginia, Greene, Stephen A., Lohmer, Lauren, Kramer, Michael S., Arscott, Kelly, James, Ian E., Demitrack, Mark A.
Published in CNS drugs (01.08.2020)
Published in CNS drugs (01.08.2020)
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A PHASE 1, SINGLE ASCENDING DOSE STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF SRSD107 IN HEALTHY ADULT SUBJECTS
Li, Shuya, Yue, Patrick, Wang, Weicong, Qu, Emma, pan, jie, ji, qunsheng
Published in Journal of the American College of Cardiology (01.04.2025)
Published in Journal of the American College of Cardiology (01.04.2025)
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92-LB: Safety, Tolerability, and Clinical Effects of ZP8396, a Novel Long-Acting Amylin Analog—A Single Ascending Dose Trial
OLSEN, MINNA B., HÖVELMANN, ULRIKE, GRIFFIN, JON, KNUDSEN, KIM M., JOHANSEN, THUE, KENDALL, DAVID, HEISE, TIM
Published in Diabetes (New York, N.Y.) (20.06.2023)
Published in Diabetes (New York, N.Y.) (20.06.2023)
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Intranasal dexmedetomidine in elderly subjects with or without beta blockade: a randomised double-blind single-ascending-dose cohort study
Barends, Clemens R.M., Driesens, Mendy K., Struys, Michel M.R.F., Visser, Anita, Absalom, Anthony R.
Published in British journal of anaesthesia : BJA (01.04.2020)
Published in British journal of anaesthesia : BJA (01.04.2020)
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Safety, pharmacokinetics, and pharmacodynamics of TG103, a novel long-acting GLP-1/Fc fusion protein after a single ascending dose in Chinese healthy subjects
Jin, Jiangli, Cui, Gang, Mi, Na, Wu, Wei, Zhang, Xin, Xiao, Chunyan, Wang, Jing, Qiu, Xueying, Han, Mai, Li, Ziyan, Wang, Lei, Lu, Tong, Niu, Huikun, Wu, Zhaoxi, Li, Jintong
Published in European journal of pharmaceutical sciences (01.06.2023)
Published in European journal of pharmaceutical sciences (01.06.2023)
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Single-Ascending-Dose, Food-Effect, and Multiple-Dose Study of the Safety, Tolerability, and Pharmacokinetics of the Pangenotypic Anti-Hepatitis C Virus Drug Holybuvir in Healthy Chinese Subjects
Cao, Yuran, Wu, Xiaojie, Wang, Zhiqiang, Huang, Yuxian, Wu, Junzhen, Cao, Guoying, Yu, Jicheng, Wang, Jingjing, Yang, Haijing, Zhang, Wenhong, Zhang, Jing
Published in Antimicrobial agents and chemotherapy (16.03.2023)
Published in Antimicrobial agents and chemotherapy (16.03.2023)
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