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Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of the β-Lactamase Inhibitor Vaborbactam (RPX7009) in Healthy Adult Subjects
Griffith, David C., Loutit, Jeffery S., Morgan, Elizabeth E., Durso, Stephanie, Dudley, Michael N.
Published in Antimicrobial agents and chemotherapy (01.10.2016)
Published in Antimicrobial agents and chemotherapy (01.10.2016)
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Efficacy, Safety, and Durability of Voretigene Neparvovec-rzyl in RPE65 Mutation-Associated Inherited Retinal Dystrophy: Results of Phase 1 and 3 Trials
Maguire, Albert M, Russell, Stephen, Wellman, Jennifer A, Chung, Daniel C, Yu, Zi-Fan, Tillman, Amy, Wittes, Janet, Pappas, Julie, Elci, Okan, Marshall, Kathleen A, McCague, Sarah, Reichert, Hannah, Davis, Maria, Simonelli, Francesca, Leroy, Bart P, Wright, J Fraser, High, Katherine A, Bennett, Jean
Published in Ophthalmology (Rochester, Minn.) (01.09.2019)
Published in Ophthalmology (Rochester, Minn.) (01.09.2019)
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MEDI0382, a GLP‐1/glucagon receptor dual agonist, meets safety and tolerability endpoints in a single‐dose, healthy‐subject, randomized, Phase 1 study
Ambery, Philip D., Klammt, Sebastian, Posch, Maximillian G., Petrone, Marcella, Pu, Wenji, Rondinone, Cristina, Jermutus, Lutz, Hirshberg, Boaz
Published in British journal of clinical pharmacology (01.10.2018)
Published in British journal of clinical pharmacology (01.10.2018)
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Effects of AMG 145 on Low-Density Lipoprotein Cholesterol Levels: Results From 2 Randomized, Double-Blind, Placebo-Controlled, Ascending-Dose Phase 1 Studies in Healthy Volunteers and Hypercholesterolemic Subjects on Statins
DIAS, Clapton S, SHAYWITZ, Adam J, GIBBS, John P, RETTER, Marc W, COOKE, Blaire P, UY, Stephen T, MATSON, Mark, STEIN, Evan A, WASSERMAN, Scott M, SMITH, Brian P, BING GAO, STOLMAN, Dina S, CRISPINO, Caroline P, SMIRNAKIS, Karen V, EMERY, Maurice G, COLBERT, Alexander
Published in Journal of the American College of Cardiology (06.11.2012)
Published in Journal of the American College of Cardiology (06.11.2012)
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A Phase 1, Open‐Label, Parallel‐Group, Single‐Dose Trial of the Pharmacokinetics and Safety of Cannabidiol (CBD) in Subjects With Mild to Severe Hepatic Impairment
Taylor, Lesley, Crockett, Julie, Tayo, Bola, Morrison, Gilmour
Published in Journal of clinical pharmacology (01.08.2019)
Published in Journal of clinical pharmacology (01.08.2019)
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Umbilical cord mesenchymal stem cells for COVID‐19 acute respiratory distress syndrome: A double‐blind, phase 1/2a, randomized controlled trial
Lanzoni, Giacomo, Linetsky, Elina, Correa, Diego, Messinger Cayetano, Shari, Alvarez, Roger A., Kouroupis, Dimitrios, Alvarez Gil, Ana, Poggioli, Raffaella, Ruiz, Phillip, Marttos, Antonio C., Hirani, Khemraj, Bell, Crystal A., Kusack, Halina, Rafkin, Lisa, Baidal, David, Pastewski, Andrew, Gawri, Kunal, Leñero, Clarissa, Mantero, Alejandro M. A., Metalonis, Sarah W., Wang, Xiaojing, Roque, Luis, Masters, Burlett, Kenyon, Norma S., Ginzburg, Enrique, Xu, Xiumin, Tan, Jianming, Caplan, Arnold I., Glassberg, Marilyn K., Alejandro, Rodolfo, Ricordi, Camillo
Published in Stem cells translational medicine (01.05.2021)
Published in Stem cells translational medicine (01.05.2021)
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Phase 1 Evaluation of [64Cu]DOTA-Patritumab to Assess Dosimetry, Apparent Receptor Occupancy, and Safety in Subjects with Advanced Solid Tumors
Lockhart, A. Craig, Liu, Yongjian, Dehdashti, Farrokh, Laforest, Richard, Picus, Joel, Frye, Jennifer, Trull, Lauren, Belanger, Stefanie, Desai, Madhuri, Mahmood, Syed, Mendell, Jeanne, Welch, Michael J., Siegel, Barry A.
Published in Molecular imaging and biology (01.06.2016)
Published in Molecular imaging and biology (01.06.2016)
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Rimegepant 75 mg in Subjects With Hepatic Impairment: Results of a Phase 1, Open‐Label, Single‐Dose, Parallel‐Group Study
Bhardwaj, Rajinder, Ivans, Andrea, Stringfellow, Joseph, Morris, Beth, Coric, Vladimir, Croop, Robert, Bertz, Richard
Published in Clinical pharmacology in drug development (01.08.2023)
Published in Clinical pharmacology in drug development (01.08.2023)
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A Phase 1, Open‐Label, Pharmacokinetic Trial to Investigate Possible Drug‐Drug Interactions Between Clobazam, Stiripentol, or Valproate and Cannabidiol in Healthy Subjects
Morrison, Gilmour, Crockett, Julie, Blakey, Graham, Sommerville, Kenneth
Published in Clinical pharmacology in drug development (01.11.2019)
Published in Clinical pharmacology in drug development (01.11.2019)
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Pharmacokinetics of Upadacitinib in Healthy Subjects and Subjects With Rheumatoid Arthritis, Crohn's Disease, Ulcerative Colitis, or Atopic Dermatitis: Population Analyses of Phase 1 and 2 Clinical Trials
Nader, Ahmed, Stodtmann, Sven, Friedel, Anna, Mohamed, Mohamed-Eslam F, Othman, Ahmed A
Published in Journal of clinical pharmacology (01.04.2020)
Published in Journal of clinical pharmacology (01.04.2020)
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Evaluation of a Janus kinase 1 inhibitor, PF‐04965842, in healthy subjects: A phase 1, randomized, placebo‐controlled, dose‐escalation study
Peeva, Elena, Hodge, Martin R., Kieras, Elizabeth, Vazquez, Michael L., Goteti, Kosalaram, Tarabar, Sanela G., Alvey, Christine W., Banfield, Christopher
Published in British journal of clinical pharmacology (01.08.2018)
Published in British journal of clinical pharmacology (01.08.2018)
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STOP 101: A Phase 1, Randomized, Open‐Label, Comparative Bioavailability Study of INP104, Dihydroergotamine Mesylate (DHE) Administered Intranasally by a I123 Precision Olfactory Delivery (POD®) Device, in Healthy Adult Subjects
Shrewsbury, Stephen B., Jeleva, Maria, Satterly, Kelsey H., Lickliter, Jason, Hoekman, John
Published in Headache (01.03.2019)
Published in Headache (01.03.2019)
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A Randomized Phase 1 Pharmacokinetic Study Comparing the Potential Biosimilar LRG201902 With Liraglutide (Victoza®) in Healthy Male Subjects
Mai, Gang, Fan, Lianlian, Li, Mupeng, Zhang, Peiwen, Gan, Chunyan, Huang, Qian, Shentu, Jianzhong
Published in Frontiers in pharmacology (29.01.2021)
Published in Frontiers in pharmacology (29.01.2021)
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829-P: Once-Weekly Insulin SHR-3167 in Healthy Subjects and Type 2 Diabetes Mellitus Participants—A Phase 1, Randomized, Single- and Multiple-Ascending Dose Study
LIU, YUN, ZHOU, HONGWEN, MENG, CHAO, PAN, TIANRONG, WANG, YUAN, SHEN, KAI, DONG, YANLI, ZENG, MEIFANG, XIANG, LIPING, MA, YANLIN
Published in Diabetes (New York, N.Y.) (20.06.2025)
Published in Diabetes (New York, N.Y.) (20.06.2025)
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PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial
Narayan, Vivek, Barber-Rotenberg, Julie S., Jung, In-Young, Lacey, Simon F., Rech, Andrew J., Davis, Megan M., Hwang, Wei-Ting, Lal, Priti, Carpenter, Erica L., Maude, Shannon L., Plesa, Gabriela, Vapiwala, Neha, Chew, Anne, Moniak, Michael, Sebro, Ronnie A., Farwell, Michael D., Marshall, Amy, Gilmore, Joan, Lledo, Lester, Dengel, Karen, Church, Sarah E., Hether, Tyler D., Xu, Jun, Gohil, Mercy, Buckingham, Thomas H., Yee, Stephanie S., Gonzalez, Vanessa E., Kulikovskaya, Irina, Chen, Fang, Tian, Lifeng, Tien, Kyle, Gladney, Whitney, Nobles, Christopher L., Raymond, Hayley E., Hexner, Elizabeth O., Siegel, Donald L., Bushman, Frederic D., June, Carl H., Fraietta, Joseph A., Haas, Naomi B.
Published in Nature medicine (01.04.2022)
Published in Nature medicine (01.04.2022)
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Phase 1/2 trial of talazoparib in combination with temozolomide in children and adolescents with refractory/recurrent solid tumors including Ewing sarcoma: A Children's Oncology Group Phase 1 Consortium study (ADVL1411)
Schafer, Eric S., Rau, Rachel E., Berg, Stacey L., Liu, Xiaowei, Minard, Charles G., Bishop, Alexander J.R., Romero, J. Carolina, Hicks, M. John, Nelson, Marvin D., Voss, Stephan, Reid, Joel M., Fox, Elizabeth, Weigel, Brenda J., Blaney, Susan M.
Published in Pediatric blood & cancer (01.02.2020)
Published in Pediatric blood & cancer (01.02.2020)
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Phase 1 Clinical Trial of a Conditionally Replication-Defective Human Cytomegalovirus (CMV) Vaccine in CMV-Seronegative Subjects
Adler, Stuart P., Lewis, Nicole, Conlon, Anthony, Christiansen, Mark P., Al-Ibrahim, Mohamed, Rupp, Richard, Fu, Tong-Ming, Bautista, Oliver, Tang, Huaping, Wang, Dai, Fisher, Alison, Culp, Timothy, Das, Rituparna, Beck, Karen, Tamms, Gretchen, Musey, Luwy
Published in The Journal of infectious diseases (02.07.2019)
Published in The Journal of infectious diseases (02.07.2019)
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Efficacy and Safety of Alirocumab in Japanese Subjects (Phase 1 and 2 Studies)
Teramoto, Tamio, Kobayashi, Masahiko, Uno, Kiyoko, Takagi, Yoshiharu, Matsuoka, Osamu, Sugimoto, Masayuki, Inoue, Satoshi, Minami, Fumiko, Baccara-Dinet, Marie Thérèse
Published in The American journal of cardiology (01.07.2016)
Published in The American journal of cardiology (01.07.2016)
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