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The orexin story and orexin receptor antagonists for the treatment of insomnia
Muehlan, Clemens, Roch, Catherine, Vaillant, Cedric, Dingemanse, Jasper
Published in Journal of sleep research (01.12.2023)
Published in Journal of sleep research (01.12.2023)
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Daridorexant, a new dual orexin receptor antagonist, in elderly subjects with insomnia disorder
Zammit, Gary, Dauvilliers, Yves, Pain, Scott, Sebök Kinter, Dalma, Mansour, Yosef, Kunz, Dieter
Published in Neurology (26.05.2020)
Published in Neurology (26.05.2020)
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Orexin/hypocretin system and autonomic control: new insights and clinical correlations
Grimaldi, Daniela, Silvani, Alessandro, Benarroch, Eduardo E, Cortelli, Pietro
Published in Neurology (21.01.2014)
Published in Neurology (21.01.2014)
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Functional cardiac orexin receptors: role of orexin-B/orexin 2 receptor in myocardial protection
Patel, Vanlata H., Karteris, Emmanouil, Chen, Jing, Kyrou, Ioannis, Mattu, Harman S., Dimitriadis, Georgios K., Rodrigo, Glenn, Antoniades, Charalambos, Antonopoulos, Alexios, Tan, Bee K., Hillhouse, Edward W., Ng, Andre, Randeva, Harpal S.
Published in Clinical science (1979) (21.12.2018)
Published in Clinical science (1979) (21.12.2018)
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Daridorexant, a New Dual Orexin Receptor Antagonist to Treat Insomnia Disorder
Dauvilliers, Yves, Zammit, Gary, Fietze, Ingo, Mayleben, David, Seboek Kinter, Dalma, Pain, Scott, Hedner, Jan
Published in Annals of neurology (01.03.2020)
Published in Annals of neurology (01.03.2020)
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Population Pharmacokinetics and Exposure‐Response Analyses for the Most Frequent Adverse Events Following Treatment With Lemborexant, an Orexin Receptor Antagonist, in Subjects With Insomnia Disorder
Lalovic, Bojan, Majid, Oneeb, Aluri, Jagadeesh, Landry, Ishani, Moline, Margaret, Hussein, Ziad
Published in Journal of clinical pharmacology (01.12.2020)
Published in Journal of clinical pharmacology (01.12.2020)
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Orexin-A is Associated with Increases in Cerebrospinal Fluid Phosphorylated-Tau in Cognitively Normal Elderly Subjects
Osorio, Ricardo S., Ducca, Emma L., Wohlleber, Margaret E., Tanzi, Emily B., Gumb, Tyler, Twumasi, Akosua, Tweardy, Samuel, Lewis, Clifton, Fischer, Esther, Koushyk, Viachaslau, Cuartero-Toledo, Maria, Sheikh, Mohammed O., Pirraglia, Elizabeth, Zetterberg, Henrik, Blennow, Kaj, Lu, Shou-En, Mosconi, Lisa, Glodzik, Lidia, Schuetz, Sonja, Varga, Andrew W., Ayappa, Indu, Rapoport, David M., de Leon, Mony J.
Published in Sleep (New York, N.Y.) (01.06.2016)
Published in Sleep (New York, N.Y.) (01.06.2016)
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Pharmacokinetics and Pharmacodynamics of the Dual Orexin Receptor Antagonist Daridorexant in Japanese and Caucasian Subjects
Muehlan, Clemens, Zuiker, Rob, Peeters, Pierre, Rowles, Racheal, Dingemanse, Jasper
Published in Journal of clinical psychopharmacology (01.03.2020)
Published in Journal of clinical psychopharmacology (01.03.2020)
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Pharmacological Interactions between the Dual Orexin Receptor Antagonist Daridorexant and Ethanol in a Double-Blind, Randomized, Placebo-Controlled, Double-Dummy, Four-Way Crossover Phase I Study in Healthy Subjects
Berger, Benjamin, Brooks, Sander, Zuiker, Rob, Richard, Muriel, Muehlan, Clemens, Dingemanse, Jasper
Published in CNS drugs (01.12.2020)
Published in CNS drugs (01.12.2020)
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Multiple daytime administration of the selective orexin-2 receptor antagonist JNJ-42847922 induces somnolence in healthy subjects without residual central effects
van der Ark, Peter D, Golor, Georg, van Nueten, Luc, Nandy, Partha, de Boer, Peter
Published in Journal of psychopharmacology (Oxford) (01.12.2018)
Published in Journal of psychopharmacology (Oxford) (01.12.2018)
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CD4+ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy
De la Herrán-Arita, Alberto K, Kornum, Birgitte Rahbek, Mahlios, Josh, Jiang, Wei, Lin, Ling, Hou, Tieying, Macaubas, Claudia, Einen, Mali, Plazzi, Giuseppe, Crowe, Catherine, Newell, Evan W, Davis, Mark M, Mellins, Elizabeth D, Mignot, Emmanuel
Published in Science translational medicine (18.12.2013)
Published in Science translational medicine (18.12.2013)
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A key role for orexin in panic anxiety
Johnson, Philip L, Truitt, William, Fitz, Stephanie D, Minick, Pamela E, Dietrich, Amy, Sanghani, Sonal, Träskman-Bendz, Lil, Goddard, Andrew W, Brundin, Lena, Shekhar, Anantha
Published in Nature medicine (01.01.2010)
Published in Nature medicine (01.01.2010)
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CSF dynamics of orexin and β-amyloid42 levels in narcolepsy and Alzheimer’s disease patients: a controlled study
Lozano-Tovar, Susana, Nuccetelli, Marzia, Placidi, Fabio, Izzi, Francesca, Sancesario, Giuseppe, Bernardini, Sergio, Biagio Mercuri, Nicola, Liguori, Claudio
Published in Neuroscience letters (10.08.2024)
Published in Neuroscience letters (10.08.2024)
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Control and coding of pupil size by hypothalamic orexin neurons
Grujic, Nikola, Tesmer, Alexander, Bracey, Ed, Peleg-Raibstein, Daria, Burdakov, Denis
Published in Nature neuroscience (01.07.2023)
Published in Nature neuroscience (01.07.2023)
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Clinical pharmacology of the dual orexin receptor antagonist ACT-541468 in elderly subjects: Exploration of pharmacokinetics, pharmacodynamics and tolerability following single-dose morning and repeated-dose evening administration
Muehlan, Clemens, Boehler, Margaux, Brooks, Sander, Zuiker, Rob, van Gerven, Joop, Dingemanse, Jasper
Published in Journal of psychopharmacology (Oxford) (01.03.2020)
Published in Journal of psychopharmacology (Oxford) (01.03.2020)
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Electroencephalographic Power Spectral Density Profile of the Orexin Receptor Antagonist Suvorexant in Patients with Primary Insomnia and Healthy Subjects
Ma, Junshui, Svetnik, Vladimir, Snyder, Ellen, Lines, Christopher, Roth, Thomas, Herring, W. Joseph
Published in Sleep (New York, N.Y.) (01.10.2014)
Published in Sleep (New York, N.Y.) (01.10.2014)
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Accelerated Development of the Dual Orexin Receptor Antagonist ACT-541468: Integration of a Microtracer in a First-in-Human Study
Muehlan, Clemens, Heuberger, Jules, Juif, Pierre-Eric, Croft, Marie, van Gerven, Joop, Dingemanse, Jasper
Published in Clinical pharmacology and therapeutics (01.11.2018)
Published in Clinical pharmacology and therapeutics (01.11.2018)
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Blockade of orexin receptors in the infralimbic cortex prevents stress‐induced reinstatement of alcohol‐seeking behaviour in alcohol‐dependent rats
Flores‐Ramirez, Francisco J., Varodayan, Florence P., Patel, Reesha R., Illenberger, Jessica M., Di Ottavio, Francesca, Roberto, Marisa, Martin‐Fardon, Rémi
Published in British journal of pharmacology (01.06.2023)
Published in British journal of pharmacology (01.06.2023)
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