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The Effects of 2′-O-Methoxyethyl Containing Antisense Oligonucleotides on Platelets in Human Clinical Trials
Crooke, Stanley T., Baker, Brenda F., Witztum, Joseph L., Kwoh, T. Jesse, Pham, Nguyen C., Salgado, Nelson, McEvoy, Bradley W., Cheng, Wei, Hughes, Steven G., Bhanot, Sanjay, Geary, Richard S.
Published in Nucleic acid therapeutics (01.06.2017)
Published in Nucleic acid therapeutics (01.06.2017)
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Reduction Of Plasma Lipoprotein(A) With Antisense Oligonucleotides In Human Subjects Does Not Affect Fibrinolysis
Boffa, M., Marar, T., Borrelli, M., Yeang, C., Viney, N., Xia, S., Witztum, J., Koschinsky, M., Tsimikas, S.
Published in Atherosclerosis (01.08.2019)
Published in Atherosclerosis (01.08.2019)
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Pharmacokinetics and safety of single doses of drisapersen in non-ambulant subjects with Duchenne muscular dystrophy: Results of a double-blind randomized clinical trial
Flanigan, Kevin M., Voit, Thomas, Rosales, Xiomara Q., Servais, Laurent, Kraus, John E., Wardell, Claire, Morgan, Allison, Dorricott, Susie, Nakielny, Joanna, Quarcoo, Naashika, Liefaard, Lia, Drury, Tom, Campion, Giles, Wright, Padraig
Published in Neuromuscular disorders : NMD (01.01.2014)
Published in Neuromuscular disorders : NMD (01.01.2014)
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Lack of QT Prolongation for 2′-O-Methoxyethyl-Modified Antisense Oligonucleotides Based on Retrospective Exposure/Response Analysis of Ten Phase 1 Dose-Escalation Placebo-Controlled Studies in Healthy Subjects
Yu, Rosie Z., Gunawan, Rudy, Geary, Richard S., Hughes, Steven G., Henry, Scott P., Wang, Yanfeng
Published in Nucleic acid therapeutics (01.10.2017)
Published in Nucleic acid therapeutics (01.10.2017)
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Liver-Targeted Delivery of Oligonucleotides with N‑Acetylgalactosamine Conjugation
Cui, Hao, Zhu, Xinying, Li, Shuyue, Wang, Peipei, Fang, Jianping
Published in ACS omega (29.06.2021)
Published in ACS omega (29.06.2021)
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Changes in Cerebrospinal Fluid Concentrations of Selenium Species Induced by Tofersen Administration in Subjects with Amyotrophic Lateral Sclerosis Carrying SOD1 Gene Mutations: Changes in Cerebrospinal Fluid Concentrations of Selenium Species Induced by Tofersen Administration in Subjects with Amyotrophic Lateral Sclerosis Carrying SOD1 Gene Mutations
Vinceti, Marco, Urbano, Teresa, Filippini, Tommaso, Bedin, Roberta, Simonini, Cecilia, Sorarù, Gianni, Trojsi, Francesca, Michalke, Bernhard, Mandrioli, Jessica
Published in Biological trace element research (01.04.2025)
Published in Biological trace element research (01.04.2025)
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Lipid Conjugated Oligonucleotides: A Useful Strategy for Delivery
Raouane, Mouna, Desmaële, Didier, Urbinati, Giorgia, Massaad-Massade, Liliane, Couvreur, Patrick
Published in Bioconjugate chemistry (20.06.2012)
Published in Bioconjugate chemistry (20.06.2012)
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Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides
Østergaard, Michael E, De Hoyos, Cheryl L, Wan, W Brad, Shen, Wen, Low, Audrey, Berdeja, Andres, Vasquez, Guillermo, Murray, Susan, Migawa, Michael T, Liang, Xue-hai, Swayze, Eric E, Crooke, Stanley T, Seth, Punit P
Published in Nucleic acids research (28.02.2020)
Published in Nucleic acids research (28.02.2020)
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Weak tension accelerates hybridization and dehybridization of short oligonucleotides
Hart, Derek J, Jeong, Jiyoun, Gumbart, James C, Kim, Harold D
Published in Nucleic acids research (24.04.2023)
Published in Nucleic acids research (24.04.2023)
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Improvements in the Tolerability Profile of 2′-O-Methoxyethyl Chimeric Antisense Oligonucleotides in Parallel with Advances in Design, Screening, and Other Methods
Partridge, Wesley, Xia, Shuting, Kwoh, T Jesse, Bhanot, Sanjay, Geary, Richard S, Baker, Brenda F
Published in Nucleic acid therapeutics (01.12.2021)
Published in Nucleic acid therapeutics (01.12.2021)
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A population pharmacokinetic meta‐analysis of custirsen, an antisense oligonucleotide, in oncology patients and healthy subjects
Edwards, Alena Y., Elgart, Anna, Farrell, Colm, Barnett‐Griness, Ofra, Rabinovich‐Guilatt, Laura, Spiegelstein, Ofer
Published in British journal of clinical pharmacology (01.09.2017)
Published in British journal of clinical pharmacology (01.09.2017)
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Efficacy of apolipoprotein B synthesis inhibition in subjects with mild-to-moderate hyperlipidaemia
Akdim, Fatima, Tribble, Diane L., Flaim, JoAnn D., Yu, Rosie, Su, John, Geary, Richard S., Baker, Brenda F., Fuhr, Rainard, Wedel, Mark K., Kastelein, John J.P.
Published in European heart journal (01.11.2011)
Published in European heart journal (01.11.2011)
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Differential Expression of MicroRNAs in Omental Adipose Tissue From Gestational Diabetes Mellitus Subjects Reveals miR-222 as a Regulator of ERα Expression in Estrogen-Induced Insulin Resistance
Shi, Zhonghua, Zhao, Chun, Guo, Xirong, Ding, Hongjuan, Cui, Yugui, Shen, Rong, Liu, Jiayin
Published in Endocrinology (Philadelphia) (01.05.2014)
Published in Endocrinology (Philadelphia) (01.05.2014)
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Antisense Oligonucleotide Inhibition of Apolipoprotein C-III Reduces Plasma Triglycerides in Rodents, Nonhuman Primates, and Humans
Graham, Mark J., Lee, Richard G., Bell, Thomas A., Fu, Wuxia, Mullick, Adam E., Alexander, Veronica J., Singleton, Walter, Viney, Nick, Geary, Richard, Su, John, Baker, Brenda F., Burkey, Jennifer, Crooke, Stanley T., Crooke, Rosanne M.
Published in Circulation research (24.05.2013)
Published in Circulation research (24.05.2013)
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Efficacy and safety of pelacarsen in lowering Lp(a) in healthy Japanese subjects
Karwatowska‑Prokopczuk, Ewa, Lesogor, Anastasia, Yan, Jing-He, Hurh, Eunju, Hoenlinger, Angelika, Margolskee, Alison, Xia, Shuting, Tsimikas, Sotirios
Published in Journal of clinical lipidology (01.01.2023)
Published in Journal of clinical lipidology (01.01.2023)
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Recognition and sensing of low-epitope targets via ternary complexes with oligonucleotides and synthetic receptors
Yang, Kyung-Ae, Barbu, Mihaela, Halim, Marlin, Pallavi, Payal, Kim, Benjamin, Kolpashchikov, Dmitry M., Pecic, Stevan, Taylor, Steven, Worgall, Tilla S., Stojanovic, Milan N.
Published in Nature chemistry (01.11.2014)
Published in Nature chemistry (01.11.2014)
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Potent reduction of plasma lipoprotein (a) with an antisense oligonucleotide in human subjects does not affect ex vivo fibrinolysis
Boffa, Michael B., Marar, Tanya T., Yeang, Calvin, Viney, Nicholas J., Xia, Shuting, Witztum, Joseph L., Koschinsky, Marlys L., Tsimikas, Sotirios
Published in Journal of lipid research (01.12.2019)
Published in Journal of lipid research (01.12.2019)
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