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Physiologically based pharmacokinetic model combined with reverse dose method to study the nephrotoxic tolerance dose of tacrolimus
Cai, Limin, Ke, Meng, Wang, Han, Wu, Wanhong, Lin, Rongfang, Huang, Pinfang, Lin, Cuihong
Published in Archives of toxicology (01.10.2023)
Published in Archives of toxicology (01.10.2023)
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A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 2: Prospectively Predicting Systemic and Liver Exposure in Healthy Subjects
Li, Rui, Kimoto, Emi, Niosi, Mark, Tess, David A., Lin, Jian, Tremaine, Larry M., Di, Li
Published in Drug metabolism and disposition (01.04.2018)
Published in Drug metabolism and disposition (01.04.2018)
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Narrowing the Gap Between In Vitro and In Vivo Genetic Profiles by Deconvoluting Toxicogenomic Data In Silico
Liu, Yuan, Jing, Runyu, Wen, Zhining, Li, Menglong
Published in Frontiers in pharmacology (08.01.2020)
Published in Frontiers in pharmacology (08.01.2020)
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Relative contributions of metabolic enzymes to systemic elimination can be estimated from clinical DDI studies: Validation using an in silico approach
Koinuma, Kana, Tsuchitani, Toshiaki, Imaoka, Ayuko, Akiyoshi, Takeshi, Ohtani, Hisakazu
Published in International journal of clinical pharmacology and therapeutics (01.03.2021)
Published in International journal of clinical pharmacology and therapeutics (01.03.2021)
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The Importance of Incorporating OCT2 Plasma Membrane Expression and Membrane Potential in IVIVE of Metformin Renal Secretory Clearance
Kumar, Vineet, Yin, Jia, Billington, Sarah, Prasad, Bhagwat, Brown, Colin D.A., Wang, Joanne, Unadkat, Jashvant D.
Published in Drug metabolism and disposition (01.10.2018)
Published in Drug metabolism and disposition (01.10.2018)
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Pharmacokinetic Drug‐Drug Interactions Between Trospium Chloride and Ranitidine Substrates of Organic Cation Transporters in Healthy Human Subjects
Abebe, Bayew Tsega, Weiss, Michael, Modess, Christiane, Tadken, Tobias, Wegner, Danilo, Meyer, Marleen J., Schwantes, Ulrich, Neumeister, Claudia, Scheuch, Eberhard, Schulz, Hans‐Ulrich, Tzvetkov, Mladen, Siegmund, Werner
Published in Journal of clinical pharmacology (01.03.2020)
Published in Journal of clinical pharmacology (01.03.2020)
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Determination of Human Hepatic CYP2C8 and CYP1A2 Age-Dependent Expression to Support Human Health Risk Assessment for Early Ages
Song, Gina, Sun, Xueying, Hines, Ronald N., McCarver, D. Gail, Lake, Brian G., Osimitz, Thomas G., Creek, Moire R., Clewell, Harvey J., Yoon, Miyoung
Published in Drug metabolism and disposition (01.05.2017)
Published in Drug metabolism and disposition (01.05.2017)
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Deciding on Success Criteria for Predictability of Pharmacokinetic Parameters from In Vitro Studies: An Analysis Based on In Vivo Observations
Abduljalil, Khaled, Cain, Theresa, Humphries, Helen, Rostami-Hodjegan, Amin
Published in Drug metabolism and disposition (01.09.2014)
Published in Drug metabolism and disposition (01.09.2014)
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Linking physiological parameters to perturbations in the human exposome: Environmental exposures modify blood pressure and lung function via inflammatory cytokine pathway
Stiegel, Matthew A., Pleil, Joachim D., Sobus, Jon R., Stevens, Tina, Madden, Michael C.
Published in Journal of Toxicology and Environmental Health, Part A (01.01.2017)
Published in Journal of Toxicology and Environmental Health, Part A (01.01.2017)
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Estimating uncertainty in the context of new approach methodologies for potential use in chemical safety evaluation
Pham, Ly Ly, Sheffield, Thomas Y., Pradeep, Prachi, Brown, Jason, Haggard, Derik E., Wambaugh, John, Judson, Richard S., Paul Friedman, Katie
Published in Current opinion in toxicology (01.06.2019)
Published in Current opinion in toxicology (01.06.2019)
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Mechanistic bottom-up estimation of passive drug absorption from the gastrointestinal tract: Comparison among primary cultured human intestinal cells, Caco-2 cells, artificial membrane, and animal scale-up
Tsuchitani, Toshiaki, Akiyoshi, Takeshi, Imaoka, Ayuko, Ohtani, Hisakazu
Published in International journal of clinical pharmacology and therapeutics (01.05.2022)
Published in International journal of clinical pharmacology and therapeutics (01.05.2022)
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