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A first-in-Asian phase 1 study to evaluate safety, pharmacokinetics and clinical activity of VS-6063, a focal adhesion kinase (FAK) inhibitor in Japanese patients with advanced solid tumors
Shimizu, Toshio, Fukuoka, Kazuya, Takeda, Masayuki, Iwasa, Tutomu, Yoshida, Takeshi, Horobin, Joanna, Keegan, Mitchell, Vaickus, Lou, Chavan, Ajit, Padval, Mahesh, Nakagawa, Kazuhiko
Published in Cancer chemotherapy and pharmacology (01.05.2016)
Published in Cancer chemotherapy and pharmacology (01.05.2016)
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A phase Ib dose-finding, pharmacokinetic study of the focal adhesion kinase inhibitor GSK2256098 and trametinib in patients with advanced solid tumours
Mak, Gabriel, Soria, Jean-Charles, Blagden, Sarah P., Plummer, Ruth, Fleming, Ronald A., Nebot, Noelia, Zhang, Jianping, Mazumdar, Jolly, Rogan, Debra, Gazzah, Anas, Rizzuto, Ivana, Greystoke, Alastair, Yan, Li, Tolson, Jerry, Auger, Kurt R., Arkenau, Hendrik-Tobias
Published in British journal of cancer (14.05.2019)
Published in British journal of cancer (14.05.2019)
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Modulation of endothelial cell migration by extracellular nucleotides: involvement of focal adhesion kinase and phosphatidylinositol 3-kinase-mediated pathways
Kaczmarek, Elzbieta, Erb, Laurie, Koziak, Katarzyna, Jarzyna, Robert, Wink, Marcia R, Guckelberger, Olaf, Blusztajn, J Krzysztof, Trinkaus-Randall, Vickery, Weisman, Gary A, Robson, Simon C
Published in Thrombosis and haemostasis (01.04.2005)
Published in Thrombosis and haemostasis (01.04.2005)
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A novel inhibitor, 16-hydroxy-cleroda-3,13-dien-16,15-olide, blocks the autophosphorylation site of focal adhesion kinase (Y397) by molecular docking
Thiyagarajan, Varadharajan, Lin, Shih-Hung, Chia, Yi-Chen, Weng, Ching-Feng
Published in Biochimica et biophysica acta (01.08.2013)
Published in Biochimica et biophysica acta (01.08.2013)
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Spatial arrangement of LD motif-interacting residues on focal adhesion targeting domain of Focal Adhesion Kinase determine domain-motif interaction affinity and specificity
Gupta, Anjali Bansal, Mukherjee, Somsubhro, Pan, Catherine Quirong, Velazquez-Campoy, Adrian, Sivaraman, J., Low, Boon Chuan
Published in Biochimica et biophysica acta. General subjects (01.01.2020)
Published in Biochimica et biophysica acta. General subjects (01.01.2020)
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Trial in progress: A randomized phase II study of pembrolizumab with or without defactinib, a focal adhesion kinase inhibitor, following chemotherapy as a neoadjuvant and adjuvant treatment for resectable pancreatic ductal adenocarcinoma (PDAC)
Davelaar, John, Brown, Zachariah, Linden, Sheila, Rodriguez, Christina, Elmadbouh, Omer, Pachter, Jonathan A., Gong, Jun, Hendifar, Andrew Eugene, Lo, Simon, Gaddam, Srinivas, Nissen, Nicholas, Burkhart, Richard A., Zheng, Lei, Osipov, Arsen
Published in Journal of clinical oncology (01.06.2022)
Published in Journal of clinical oncology (01.06.2022)
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Focal adhesion kinase and reactive oxygen species contribute to the persistent fibrotic phenotype of lesional scleroderma fibroblasts
Shi-wen, X., Thompson, K., Khan, K., Liu, S., Murphy-Marshman, H., Baron, M., Denton, C. P., Leask, A., Abraham, D. J.
Published in Rheumatology (Oxford, England) (01.12.2012)
Published in Rheumatology (Oxford, England) (01.12.2012)
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Calcium Mobilization in Unfavorable-Prognosis Chronic Lymphocytic Leukemia Patients Mediates Focal Adhesion Kinase (FAK) Cleavage, Thereby Its Activation
Frezzato, Federica, Martini, Veronica, Severin, Filippo, Raggi, Flavia, Piccoli, Marco, Visentin, Andrea, Scomazzon, Edoardo, Pravato, Stefano, Imbergamo, Silvia, Piazza, Francesco, Facco, Monica, Semenzato, Gianpietro, Trentin, Livio
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Caveolin-1 promotes trophoblast cell invasion through the focal adhesion kinase (FAK) signalling pathway during early human placental development
Dai, Zhihui, Sheng, Fei, Sun, Ningxia, Ji, Yixuan, Liao, Qiuying, Sun, Shuhan, Yang, Fu, Li, Wen
Published in Reproduction fertility and development (01.05.2019)
Published in Reproduction fertility and development (01.05.2019)
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Impaired Expression of Focal Adhesion Kinase in Mesenchymal Stromal Cells from Low-Risk Myelodysplastic Syndrome Patients
Wu, Yuenv, Aanei, Carmen Mariana, Kesr, Sanae, Picot, Tiphanie, Guyotat, Denis, Campos Catafal, Lydia
Published in Frontiers in oncology (08.08.2017)
Published in Frontiers in oncology (08.08.2017)
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Efficacy of Focal Adhesion Kinase Inhibition in Combination with Dasatinib in BCR-ABL1 Acute Lymphoblastic Leukemia
Churchman, Michelle L., Jones, Luke, Evans, Kathryn, Richmond, Jennifer, Shapiro, Irina M, Pachter, Jonathan A., Weaver, David T., Houghton, Peter J, Smith, Malcolm A., Lock, Richard B, Mullighan, Charles G.
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
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Focal Adhesion Kinase and Paxillin: Novel Regulators of Brain Sexual Differentiation?
Speert, Debra B., Konkle, Anne T. M., Zup, Susan L., Schwarz, Jaclyn M., Shiroor, Chaitanya, Taylor, Michael E., McCarthy, Margaret M.
Published in Endocrinology (Philadelphia) (01.07.2007)
Published in Endocrinology (Philadelphia) (01.07.2007)
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Repetitive Deformation Activates Focal Adhesion Kinase and ERK Mitogenic Signals in Human Caco-2 Intestinal Epithelial Cells through Src and Rac1
Chaturvedi, Lakshmi S., Marsh, H. Michael, Shang, Xun, Zheng, Yi, Basson, Marc D.
Published in The Journal of biological chemistry (05.01.2007)
Published in The Journal of biological chemistry (05.01.2007)
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Resealing of endothelial junctions by focal adhesion kinase
Quadri, Sadiqa K, Bhattacharya, Jahar
Published in American journal of physiology. Lung cellular and molecular physiology (01.01.2007)
Published in American journal of physiology. Lung cellular and molecular physiology (01.01.2007)
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296 A first-in-Asian phase I dose escalation study to evaluate the safety and pharmacokinetics of VS-6063 (defactinib), a focal adhesion kinase inhibitor in subjects with non-hematologic malignancies
Shimizu, T., Aida, H., Horobin, J., Keegan, M., Padval, M., Poli, A., Hashii, C., Nakagawa, K.
Published in European journal of cancer (1990) (01.11.2014)
Published in European journal of cancer (1990) (01.11.2014)
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Focal adhesion kinase as well as p130Cas and paxillin is crucially involved in the enhanced malignant properties under expression of ganglioside GD3 in melanoma cells
Hamamura, Kazunori, Tsuji, Momoko, Ohkawa, Yuki, Nakashima, Hideyuki, Miyazaki, Sayaka, Urano, Takeshi, Yamamoto, Noriyuki, Ueda, Minoru, Furukawa, Koichi, Furukawa, Keiko
Published in Biochimica et biophysica acta (01.03.2008)
Published in Biochimica et biophysica acta (01.03.2008)
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Hyaluronic acid engrafted metformin loaded graphene oxide nanoparticle as CD44 targeted anti-cancer therapy for triple negative breast cancer
Basu, Arijita, Upadhyay, Priyanka, Ghosh, Avijit, Bose, Aparajita, Gupta, Payal, Chattopadhyay, Sreya, Chattopadhyay, Dipankar, Adhikary, Arghya
Published in Biochimica et biophysica acta. General subjects (01.03.2021)
Published in Biochimica et biophysica acta. General subjects (01.03.2021)
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