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Suppressing the intestinal farnesoid X receptor/sphingomyelin phosphodiesterase 3 axis decreases atherosclerosis
Wu, Qing, Sun, Lulu, Hu, Xiaomin, Wang, Xuemei, Xu, Feng, Chen, Bo, Liang, Xianyi, Xia, Jialin, Wang, Pengcheng, Aibara, Daisuke, Zhang, Shaofei, Zeng, Guangyi, Yun, Chuyu, Yan, Yu, Zhu, Yicheng, Bustin, Michael, Zhang, Shuyang, Gonzalez, Frank J., Jiang, Changtao
Published in The Journal of clinical investigation (01.05.2021)
Published in The Journal of clinical investigation (01.05.2021)
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EDP‐297: A novel, farnesoid X receptor agonist—Results of a phase I study in healthy subjects
Marotta, Christine, Ahmad, Alaa, Luo, Ed, Oosterhaven, Jart, Marle, Sjoerd, Adda, Nathalie
Published in Clinical and translational science (01.02.2023)
Published in Clinical and translational science (01.02.2023)
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Suppressed farnesoid X receptor by iron overload in mice and humans potentiates iron‐induced hepatotoxicity
Xiong, Hui, Zhang, Chunze, Han, Lifeng, Xu, Tong, Saeed, Khawar, Han, Jing, Liu, Jing, Klaassen, Curtis D., Gonzalez, Frank J., Lu, Yuanfu, Zhang, Youcai
Published in Hepatology (Baltimore, Md.) (01.08.2022)
Published in Hepatology (Baltimore, Md.) (01.08.2022)
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Safety and Sustained Efficacy of the Farnesoid X Receptor (FXR) Agonist Cilofexor Over a 96-Week Open-label Extension in Patients With PSC
Trauner, Michael, Bowlus, Christopher L., Gulamhusein, Aliya, Hameed, Bilal, Caldwell, Stephen H., Shiffman, Mitchell L., Landis, Charles, Muir, Andrew J., Billin, Andrew, Xu, Jun, Liu, Xiangyu, Lu, Xiaomin, Chung, Chuhan, Myers, Robert P., Kowdley, Kris V.
Published in Clinical gastroenterology and hepatology (01.06.2023)
Published in Clinical gastroenterology and hepatology (01.06.2023)
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Farnesoid X receptor alleviates age‐related proliferation defects in regenerating mouse livers by activating forkhead box m1b transcription
Chen, Wei‐Dong, Wang, Yan‐Dong, Zhang, Lisheng, Shiah, Steven, Wang, Meihua, Yang, Fan, Yu, Donna, Forman, Barry M., Huang, Wendong
Published in Hepatology (Baltimore, Md.) (01.03.2010)
Published in Hepatology (Baltimore, Md.) (01.03.2010)
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Hepatic farnesoid X receptor protein level and circulating fibroblast growth factor 19 concentration in children with NAFLD
Nobili, Valerio, Alisi, Anna, Mosca, Antonella, Della Corte, Claudia, Veraldi, Silvio, De Vito, Rita, De Stefanis, Cristiano, D'Oria, Valentina, Jahnel, Joerg, Zohrer, Evelyn, Scorletti, Eleonora, Byrne, Christopher D.
Published in Liver international (01.02.2018)
Published in Liver international (01.02.2018)
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Suppressing the intestinal farnesoid X receptor/ sphingomyelin phosphodiesterase 3 axis decreases atherosclerosis
Wu, Qing, Sun, Lulu, Hu, Xiaomin, Wang, Xuemei, Xu, Feng, Chen, Bo, Liang, Xianyi, Xia, Jialin, Wang, Pengcheng, Aibara, Daisuke, Zhang, Shaofei, Zeng, Guangyi, Yun, Chuyu, Yan, Yu, Zhu, Yicheng, Bustin, Michael, Zhang, Shuyang, Gonzalez, Frank J, Jiang, Changtao
Published in The Journal of clinical investigation (01.05.2021)
Published in The Journal of clinical investigation (01.05.2021)
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The pharmacokinetics, pharmacodynamics, and short-term safety of cilofexor, a nonsteroidal farnesoid X receptor agonist, in subjects with hepatic impairment
Hsueh, Chia-Hsiang, Billin, Andrew, Li, Shirley, Lin, Stephen, Xiao, Deqing, Chung, Chuhan, Myers, Robert, Weber, Elijah, Nelson, Cara
Published in Journal of hepatology (01.08.2020)
Published in Journal of hepatology (01.08.2020)
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Farnesoid X Receptor-Mediated Cytoplasmic Translocation of CRTC2 Disrupts CREB-BDNF Signaling in Hippocampal CA1 and Leads to the Development of Depression-Like Behaviors in Mice
Hu, Wenfeng, Wu, Jingjing, Ye, Ting, Chen, Zhuo, Tao, Jinhua, Tong, Lijuan, Ma, Kai, Wen, Jie, Wang, Hui, Huang, Chao
Published in The international journal of neuropsychopharmacology (10.12.2020)
Published in The international journal of neuropsychopharmacology (10.12.2020)
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Inactivation of Adenomatous Polyposis Coli Reduces Bile Acid/Farnesoid X Receptor Expression through Fxr gene CpG Methylation in Mouse Colon Tumors and Human Colon Cancer Cells
Selmin, Ornella I, Fang, Changming, Lyon, Adam M, Doetschman, Tom C, Thompson, Patricia A, Martinez, Jesse D, Smith, Jeffrey W, Lance, Peter M, Romagnolo, Donato F
Published in The Journal of nutrition (01.02.2016)
Published in The Journal of nutrition (01.02.2016)
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FRI092 - The pharmacokinetics, pharmacodynamics, and short-term safety of cilofexor, a nonsteroidal farnesoid X receptor agonist, in subjects with hepatic impairment
Hsueh, Chia-Hsiang, Billin, Andrew, Li, Shirley, Lin, Stephen, Xiao, Deqing, Chung, Chuhan, Myers, Robert, Weber, Elijah, Nelson, Cara
Published in Journal of hepatology (01.08.2020)
Published in Journal of hepatology (01.08.2020)
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Safety, tolerability, pharmacokinetics and pharmacodynamics of a novel farnesoid X receptor (FXR) agonist-TQA3526 in healthy Chinese volunteers: a double-blind, randomized, placebo-controlled, dose-escalation, food effect phase I study
Xu, Jia, Zhang, Hong, Chen, Hong, Zhu, Xiaoxue, Jia, Haiyan, Xu, Zhongnan, Huo, Dandan, Zhang, Hong, Li, Cuiyun, Ding, Yanhua
Published in Annals of medicine (Helsinki) (2023)
Published in Annals of medicine (Helsinki) (2023)
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Role of Obeticholic Acid, a Farnesoid X Receptor Agonist, in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis
Kamrul-Hasan, ABM, Mondal, Sunetra, Nagendra, Lakshmi, Sasikanth, Thanikai, Ahammed, Afsar, Rahman, Shahin Ibn, Wickramarachchi, Ashani, Parajuli, Naresh, Khatiwada, Saurav, Dutta, Deep
Published in TouchREVIEWS in endocrinology (01.10.2024)
Published in TouchREVIEWS in endocrinology (01.10.2024)
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A Study to Evaluate Relative Bioavailability, Food Effect, and Pharmacodynamics of Tropifexor, a Farnesoid X Receptor Agonist, in Healthy Participants
Stringer, Rowan, Chen, Jin, Shah, Bharti, Gu, Jessie, Zhang, Yiming, Prince, William, Klickstein, Lloyd B., Woessner, Ralph
Published in Clinical pharmacology in drug development (01.02.2023)
Published in Clinical pharmacology in drug development (01.02.2023)
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First-in-Human study of LMB763, a novel, orally-available farnesoid X receptor agonist that demonstrates modulation of the pharmacodynamic markers FGF19 and C4 in healthy subjects
Huttner, K, Desai, S, DeCristofaro, M, Laffitte, B, Lin, T, Chen, J, Klickstein, L, Badman, M.K
Published in Journal of hepatology (2017)
Published in Journal of hepatology (2017)
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