The BET Family of Proteins Targets Moloney Murine Leukemia Virus Integration near Transcription Start Sites
De Rijck, Jan, de Kogel, Christine, Demeulemeester, Jonas, Vets, Sofie, El Ashkar, Sara, Malani, Nirav, Bushman, Frederic D., Landuyt, Bart, Husson, Steven J., Busschots, Katrien, Gijsbers, Rik, Debyser, Zeger
Published in Cell reports (Cambridge) (01.11.2013)
Published in Cell reports (Cambridge) (01.11.2013)
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Unlike Its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival
Van Belle, Siska, El Ashkar, Sara, Čermáková, Kateřina, Matthijssens, Filip, Goossens, Steven, Canella, Alessandro, Hodges, Courtney H, Christ, Frauke, De Rijck, Jan, Van Vlierberghe, Pieter, Veverka, Václav, Debyser, Zeger
Published in Cells (Basel, Switzerland) (19.01.2021)
Published in Cells (Basel, Switzerland) (19.01.2021)
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Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation
Sharma, Subhalakshmi, Čermáková, Kateǐina, De Rijck, Jan, Demeulemeester, Jonas, Fábry, Milan, Ashkar, Sara El, Van Belle, Siska, Lepšík, Martin, Tesina, Petr, Duchoslav, Vojtěch, Novák, Petr, Hubálek, Martin, Srb, Pavel, Christ, Frauke, Řezáčová, Pavlína, Hodges, H. Courtney, Debyser, Zeger, Veverka, Václav
Published in Proceedings of the National Academy of Sciences - PNAS (24.07.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (24.07.2018)
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Validation and structural characterization of the LEDGF/p75-MLL interface as a new target for the treatment of MLL-dependent leukemia
Cermáková, Kateřina, Tesina, Petr, Demeulemeester, Jonas, El Ashkar, Sara, Méreau, Hélène, Schwaller, Juerg, Rezáčová, Pavlína, Veverka, Vaclav, De Rijck, Jan
Published in Cancer research (Chicago, Ill.) (15.09.2014)
Published in Cancer research (Chicago, Ill.) (15.09.2014)
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BET-Independent Murine Leukemia Virus Integration Is Retargeted In Vivo and Selects Distinct Genomic Elements for Lymphomagenesis
Nombela, Ivan, Michiels, Martine, Van Looveren, Dominique, Marcelis, Lukas, el Ashkar, Sara, Van Belle, Siska, Bruggemans, Anne, Tousseyn, Thomas, Schwaller, Jürg, Christ, Frauke, Gijsbers, Rik, De Rijck, Jan, Debyser, Zeger
Published in Microbiology spectrum (31.08.2022)
Published in Microbiology spectrum (31.08.2022)
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Journal Article
BET-independent MLV-based Vectors Target Away From Promoters and Regulatory Elements
El Ashkar, Sara, De Rijck, Jan, Demeulemeester, Jonas, Vets, Sofie, Madlala, Paradise, Cermakova, Katerina, Debyser, Zeger, Gijsbers, Rik
Published in Molecular therapy. Nucleic acids (01.07.2014)
Published in Molecular therapy. Nucleic acids (01.07.2014)
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Engineering Next-Generation BET-Independent MLV Vectors for Safer Gene Therapy
El Ashkar, Sara, Van Looveren, Dominique, Schenk, Franziska, Vranckx, Lenard S., Demeulemeester, Jonas, De Rijck, Jan, Debyser, Zeger, Modlich, Ute, Gijsbers, Rik
Published in Molecular therapy. Nucleic acids (16.06.2017)
Published in Molecular therapy. Nucleic acids (16.06.2017)
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Journal Article
LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis
El Ashkar, Sara, Schwaller, Juerg, Pieters, Tim, Goossens, Steven, Demeulemeester, Jonas, Christ, Frauke, Van Belle, Siska, Juge, Sabine, Boeckx, Nancy, Engelman, Alan, Van Vlierberghe, Pieter, Debyser, Zeger, De Rijck, Jan
Published in Blood (04.01.2018)
Published in Blood (04.01.2018)
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Pharmacological Characterization of JNJ-75276617, a Menin-KMT2A Inhibitor, As Targeted Treatment for KMT2A-Altered and NPM1-Mutant Acute Leukemia
Kwon, Min Chul, Querolle, Olivier, Dai, Xuedong, Thuring, Jan Willem, Verhulst, Tinne, Marien, Ann, Goffin, Dries, Cai, Wei, Keersmaekers, Vikki, Eyassu, Filmon, Verstraeten, Karin, El Ashkar, Sara, Hogeling, Shanna M, Jacob, Frank, Vinken, Petra, Darville, Nicolas, Pande, Vineet, Krosky, Daniel, Urbanietz, Gregor, Verbist, Bie, Ferrante, Lucille A., Drenberg, Christina Diane, Wilson, David, Attar, Ricardo M., Schuringa, Jan Jacob, Daskalakis, Nikki, Packman, Kathryn, Pietsch, Christine, Elsayed, Yusri, Philippar, Ulrike
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Lens epithelium-derived growth factor/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis
De Rijck, Jan, El Ashkar, Sara, Schwaller, Jürg, Pieters, Tim, Goossens, Steven, Demeulemeester, Jonas, Van Vlierberghe, Pieter, Debyser, Zeger
Published in Experimental hematology (01.09.2017)
Published in Experimental hematology (01.09.2017)
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Journal Article
Validation of the MLL-LEDGF/P75 interaction as a therapeutic target for mixed lineage leukemia
El Ashkar, Sara, De Rijck, Jan, Cermakova, Katerina, Tesina, Petr, Demeulemeester, Jonas, Mereau, Helene, Schwaller, Jürg, Veverka, Václav, Řezáčová, Pavlína, Debyser, Zeger
Published in Experimental hematology (01.09.2016)
Published in Experimental hematology (01.09.2016)
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New Insights to the MLL Recombinome Including 8 Novel Partner Genes ACTN4, C2CD3, DCP1A, FLNA, LAMC3, LOC100128568, NRIP3, and TNRC18
Meyer, Claus, Kowarz, Eric, Hofmann, Julia, Fischer, Thomas, Ashkar, Sara El, Teigler-Schlegel, Andrea, Balgobind, Brian, Burmeister, Thomas, De Braekeleer, Etienne, Delabesse, Eric, Renneville, Aline, Dingermann, Theo, Klingebiel, Thomas, Marschalek, Rolf
Published in Blood (16.11.2008)
Published in Blood (16.11.2008)
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