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Association of plasma uracil concentration with 5-FU pharmacokinetics, dose-limiting toxicity, and DPYD genotype in patients with gastrointestinal cancer
Ness, Dylan B., Hourdequin, Kathryn Cunningham, Ripple, Gregory H., Amin, Manik A., Lord-Halvorson, Sierra, Khan, Wahab A., Deharvengt, Sophie J., Dragnev, Konstantin H., Tsongalis, Gregory J., Zhao, Wenyan, Tosteson, Tor D., Lewis, Lionel D
Published in Journal of clinical oncology (20.01.2024)
Published in Journal of clinical oncology (20.01.2024)
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A pharmaceutical industry survey results on the cycle time, drivers and enablers, for key deliverables in the early phase of drug product development from dose limiting toxicity to first subject first dose: The survey conducted by the IQ cycle time benchmarking working group
Campbell, Gossett A., Barrett, Stephanie E., Thakral, Seema, Lowinger, Michael, Faassen, Fried, Vander Kamp, Kirk A., Wagner, Daniel, Bargmann-Leyder, Nathalie, Badawy, Sherif, Gaebele, Tracy, Snyder, Phillip
Published in Journal of drug delivery science and technology (01.06.2025)
Published in Journal of drug delivery science and technology (01.06.2025)
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NKTT120 Reduces iNKT Cells without Dose Limiting Toxicity in Stable Adult Sickle Cell Patients in a Phase 1 Trial
Majerus, Elaine M., Ataga, Kenneth I., Vichinsky, Elliott, Eaton, Cheryl A., Mazanet, Rosemary, Nathan, David G., Field, Joshua J.
Published in Blood (06.12.2014)
Published in Blood (06.12.2014)
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Pharmacokinetics and Safety of PTC596, a Novel Tubulin‐Binding Agent, in Subjects With Advanced Solid Tumors
Shapiro, Geoffrey I., O'Mara, Edward, Laskin, Oscar L., Gao, Lan, Baird, John D., Spiegel, Robert J., Kaushik, Diksha, Weetall, Marla, Colacino, Joseph, O'Keefe, Kylie, Branstrom, Arthur, Goodwin, Elizabeth, Infante, Jeffrey, Bedard, Philippe L., Kong, Ronald
Published in Clinical pharmacology in drug development (01.08.2021)
Published in Clinical pharmacology in drug development (01.08.2021)
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Abstract B56: A phase 1, open-label, dose escalation, nonrandomized study to assess the maximum tolerated dose, dose limiting toxicity, and pharmacokinetics of OPB-31121 in subjects with advanced solid tumors
Kurzrock, Razelle, Naing, Aung, Falchook, Gerald S., Hong, David S., Elekes, Agnes, Sumida, Takumi, Bricmont, Patricia, Kodama, Takeshi, Motoyama, Masaaki, Patil, Shiva, Lee, Jennifer, Jones, Suzanne, Infante, Jeffrey, Burris, Howard, Bendell, Johanna
Published in Molecular cancer therapeutics (12.11.2011)
Published in Molecular cancer therapeutics (12.11.2011)
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A comparative study of dose-finding models with late-onset toxicities
Park, Jihyun, Park, Mira, Lee, Jae Won
Published in Communications in statistics. Simulation and computation (09.06.2025)
Published in Communications in statistics. Simulation and computation (09.06.2025)
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Safety, Tolerability, and Pharmacokinetics of NorUrsodeoxycholic Acid (Shilpa Medicare Limited, India) in Healthy Adults: Results From a Phase I Open‐Label Dose‐Escalation Study
Panuganti, Veerendra Kumar, Alluri, Chandrasekhar Varma, Dundigalla, Mamatha Reddy, Mohammad, Javeed, Madala, Pavan Kumar, K. S. S. V. V., Sanyasirao
Published in Advances in pharmacological and pharmaceutical sciences (01.01.2025)
Published in Advances in pharmacological and pharmaceutical sciences (01.01.2025)
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Moleculin Receives Approval to Extend Dose Escalation in Phase 1/2 European Clinical Trial Evaluating Annamycin for the Treatment of Acute Myeloid Leukemia: Protocol amendment allows for change in dose limiting toxicity (DLT) criteria for future enrolled subjects
Published in PR Newswire
(13.07.2021)
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Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors
Dunbar, E. M., Coats, B. S., Shroads, A. L., Langaee, T., Lew, A., Forder, J. R., Shuster, J. J., Wagner, D. A., Stacpoole, P. W.
Published in Investigational new drugs (01.06.2014)
Published in Investigational new drugs (01.06.2014)
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Macrophage Therapy for Acute Liver Injury (MAIL): a study protocol for a phase 1 randomised, open-label, dose-escalation study to evaluate safety, tolerability and activity of allogeneic alternatively activated macrophages in patients with paracetamol-induced acute liver injury in the UK
Humphries, Christopher, Addison, Melisande, Aithal, Guruprasad, Boyd, Julia, Briody, Lesley, Campbell, John D M, Candela, Maria Elena, Clarke, Ellise, Coulson, James, Downing-James, Nicholas, Fontana, Robert John, Geddes, Ailsa, Grahamslaw, Julia, Grant, Alison, Heye, Anna, Hutchinson, James A, Jones, Ashley, Mitchell, Fiona, Moore, Joanna, Riddell, Alice, Rodriguez, Aryelly, Thomas, Angela, Tucker, Garry, Walker, Kim, Weir, Christopher J, Woods, Rachel, Zahra, Sharon, Forbes, Stuart J, Dear, James W
Published in BMJ open (09.12.2024)
Published in BMJ open (09.12.2024)
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A phase 1 study investigating DX-2930 in healthy subjects
Chyung, Yung, Vince, Bradley, Iarrobino, Ryan, Sexton, Dan, Kenniston, Jon, Faucette, Ryan, TenHoor, Chris, Stolz, Leslie E., Stevens, Chris, Biedenkapp, Joseph, Adelman, Burt
Published in Annals of allergy, asthma, & immunology (01.10.2014)
Published in Annals of allergy, asthma, & immunology (01.10.2014)
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Complete Removal of Extracellular IgG Antibodies in a Randomized Dose-Escalation Phase I Study with the Bacterial Enzyme IdeS – A Novel Therapeutic Opportunity
Winstedt, Lena, Järnum, Sofia, Nordahl, Emma Andersson, Olsson, Andreas, Runström, Anna, Bockermann, Robert, Karlsson, Christofer, Malmström, Johan, Palmgren, Gabriella Samuelsson, Malmqvist, Ulf, Björck, Lars, Kjellman, Christian
Published in PloS one (2015)
Published in PloS one (2015)
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A phase I study of IMC-001, a PD-L1 blocker, in patients with metastatic or locally advanced solid tumors
Keam, Bhumsuk, Ock, Chan-Young, Kim, Tae Min, Oh, Do-Youn, Kang, Won Ki, Park, Yeon Hee, Lee, Jeeyun, Lee, Ji Hye, Ahn, Yoen Hee, Kim, Hyeon Ju, Chang, Sook Kyung, Park, Jihyun, Choi, Ji Yea, Song, Yun Jeong, Park, Young Suk
Published in Investigational new drugs (01.12.2021)
Published in Investigational new drugs (01.12.2021)
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Phase 1 trial of carfilzomib in relapsed/refractory peripheral T-cell lymphoma
Krishnan, Mridula, Bociek, R. Gregory, Fanale, Michelle, Iyer, Swaminathan P., Lechowicz, Mary Jo, Bierman, Philip J., Armitage, James O., Lunning, Matthew, Kallam, Avyakta, Vose, Julie M.
Published in Annals of hematology (01.02.2022)
Published in Annals of hematology (01.02.2022)
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Safety, Pharmacokinetics, and Pharmacodynamics of the Autotaxin Inhibitor GLPG1690 in Healthy Subjects: Phase 1 Randomized Trials
der Aar, Ellen, Desrivot, Julie, Dupont, Sonia, Heckmann, Bertrand, Fieuw, Ann, Stutvoet, Simone, Fagard, Liesbeth, Van de Wal, Karen, Helmer, Eric
Published in Journal of clinical pharmacology (01.10.2019)
Published in Journal of clinical pharmacology (01.10.2019)
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Phase I Study of Recombinant Human Interleukin-7 Administration in Subjects with Refractory Malignancy
Sportès, Claude, Babb, Rebecca R., Krumlauf, Michael C., Hakim, Frances T., Steinberg, Seth M., Chow, Catherine K., Brown, Margaret R., Fleisher, Thomas A., Noel, Pierre, Maric, Irina, Stetler-Stevenson, Maryalice, Engel, Julie, Buffet, Renaud, Morre, Michel, Amato, Robert J., Pecora, Andrew, Mackall, Crystal L., Gress, Ronald E.
Published in Clinical cancer research (15.01.2010)
Published in Clinical cancer research (15.01.2010)
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Safety and activity of WX-0593 (Iruplinalkib) in patients with ALK- or ROS1-rearranged advanced non-small cell lung cancer: a phase 1 dose-escalation and dose-expansion trial
Shi, Yuankai, Fang, Jian, Hao, Xuezhi, Zhang, Shucai, Liu, Yunpeng, Wang, Lin, Chen, Jianhua, Hu, Yi, Hang, Xiaosheng, Li, Juan, Liu, Chunling, Zhang, Yiping, Wang, Zhehai, Hu, Yanping, Gu, Kangsheng, Huang, Jian’an, Zhang, Liangming, Shan, Jinlu, Ouyang, Weiwei, Zhao, Yanqiu, Zhuang, Wu, Yu, Yan, Zhao, Jun, Zhang, Helong, Lu, Pei, Li, Weidong, Si, Meimei, Ge, Mingjing, Geng, Huaize
Published in Signal transduction and targeted therapy (28.01.2022)
Published in Signal transduction and targeted therapy (28.01.2022)
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Vaccination with Irradiated Autologous Tumor Cells Mixed with Irradiated GM-K562 Cells Stimulates Antitumor Immunity and T Lymphocyte Activation in Patients with Recurrent Malignant Glioma
Curry, William T., Gorrepati, Ramana, Piesche, Matthias, Sasada, Tetsuro, Agarwalla, Pankaj, Jones, Pamela S., Gerstner, Elizabeth R., Golby, Alexandra J., Batchelor, Tracy T., Wen, Patrick Y., Mihm, Martin C., Dranoff, Glenn
Published in Clinical cancer research (15.06.2016)
Published in Clinical cancer research (15.06.2016)
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Phase I Study of MG98, an Oligonucleotide Antisense Inhibitor of Human DNA Methyltransferase 1, Given as a 7-Day Infusion in Patients with Advanced Solid Tumors
Plummer, Ruth, Vidal, Laura, Griffin, Melanie, Lesley, Mark, de Bono, Johann, Coulthard, Sally, Sludden, Julieann, Siu, Lillian L., Chen, Eric X., Oza, Amit M., Reid, Gregory K., McLeod, A. Robert, Besterman, Jeffrey M., Lee, Chooi, Judson, Ian, Calvert, Hilary, Boddy, Alan V.
Published in Clinical cancer research (01.05.2009)
Published in Clinical cancer research (01.05.2009)
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