Extraction optimization and reactivity of 7α-acetoxy-6β-hydroxyroyleanone and ability of its derivatives to modulate PKC isoforms
Isca, Vera M S, Bangay, Gabrielle, Princiotto, Salvatore, Saraíva, Lucília, Dos Santos, Daniel J V A, García-Sosa, Alfonso T, Rijo, Patrícia
Published in Scientific reports (23.07.2024)
Published in Scientific reports (23.07.2024)
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Journal Article
Structure-function relationships in ABCG2: insights from molecular dynamics simulations and molecular docking studies
Ferreira, Ricardo J, Bonito, Cátia A, Cordeiro, M Natália D S, Ferreira, Maria-José U, Dos Santos, Daniel J V A
Published in Scientific reports (14.11.2017)
Published in Scientific reports (14.11.2017)
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Journal Article
Activity to Breast Cancer Cell Lines of Different Malignancy and Predicted Interaction with Protein Kinase C Isoforms of Royleanones
Isca, Vera M S, Sencanski, Milan, Filipovic, Nenad, Dos Santos, Daniel J V A, Čipak Gašparović, Ana, Saraíva, Lucília, Afonso, Carlos A M, Rijo, Patrícia, García-Sosa, Alfonso T
Published in International journal of molecular sciences (23.05.2020)
Published in International journal of molecular sciences (23.05.2020)
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Journal Article
Combining 1,3‐Ditriazolylbenzene and Quinoline to Discover a New G‐Quadruplex‐Interactive Small Molecule Active against Cancer Stem‐Like Cells
Mendes, Eduarda, Cadoni, Enrico, Carneiro, Filipa, Afonso, Marta B., Brito, Hugo, Lavrado, João, dos Santos, Daniel J. V. A., Vítor, Jorge B., Neidle, Stephen, Rodrigues, Cecília M. P., Paulo, Alexandra
Published in ChemMedChem (17.07.2019)
Published in ChemMedChem (17.07.2019)
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Journal Article
Exploring the Monoterpene Indole Alkaloid Scaffold for Reversing P-Glycoprotein-Mediated Multidrug Resistance in Cancer
Cardoso, David, Szemerédi, Nikoletta, Spengler, Gabriella, Mulhovo, Silva, dos Santos, Daniel, Ferreira, Maria-José
Published in Pharmaceuticals (Basel, Switzerland) (28.08.2021)
Published in Pharmaceuticals (Basel, Switzerland) (28.08.2021)
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Journal Article
Synthesis, G-Quadruplex Stabilisation, Docking Studies, and Effect on Cancer Cells of Indolo[3,2-b]quinolines with One, Two, or Three Basic Side Chains
Lavrado, João, Borralho, Pedro M., Ohnmacht, Stephan A., Castro, Rui E., Rodrigues, Cecília M. P., Moreira, Rui, Santos, Daniel J. V. A. dos, Neidle, Stephen, Paulo, Alexandra
Published in ChemMedChem (01.10.2013)
Published in ChemMedChem (01.10.2013)
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Journal Article
Indolo[3,2-c]quinoline G-Quadruplex Stabilizers: a Structural Analysis of Binding to the Human Telomeric G-Quadruplex
Lavrado, João, Ohnmacht, Stephan A., Correia, Isabel, Leitão, Clara, Pisco, Sílvia, Gunaratnam, Mekala, Moreira, Rui, Neidle, Stephen, Santos, Daniel J. V. A. dos, Paulo, Alexandra
Published in ChemMedChem (01.05.2015)
Published in ChemMedChem (01.05.2015)
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Journal Article
Terpenoids from Euphorbia pedroi as Multidrug-Resistance Reversers
Ferreira, Ricardo J, Kincses, Annamária, Gajdács, Márió, Spengler, Gabriella, dos Santos, Daniel J. V. A, Molnár, Joseph, Ferreira, Maria-José U
Published in Journal of natural products (Washington, D.C.) (28.09.2018)
Published in Journal of natural products (Washington, D.C.) (28.09.2018)
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Journal Article
Enhancing Macrocyclic Diterpenes as Multidrug-Resistance Reversers: Structure–Activity Studies on Jolkinol D Derivatives
Reis, Mariana, Ferreira, Ricardo J, Santos, Maria M. M, dos Santos, Daniel J. V. A, Molnár, Joseph, Ferreira, Maria-José U
Published in Journal of medicinal chemistry (14.02.2013)
Published in Journal of medicinal chemistry (14.02.2013)
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Journal Article
A tryptophanol-derived oxazolopiperidone lactam is cytotoxic against tumors via inhibition of p53 interaction with murine double minute proteins
Soares, Joana, Raimundo, Liliana, Pereira, Nuno A.L., dos Santos, Daniel J.V.A., Pérez, Maria, Queiroz, Glória, Leão, Mariana, Santos, Maria M.M., Saraiva, Lucília
Published in Pharmacological research (01.05.2015)
Published in Pharmacological research (01.05.2015)
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Journal Article
Molecular Docking Studies of Royleanone Diterpenoids from Plectranthus spp. as P‑Glycoprotein Inhibitors
Isca, Vera M. S, Ferreira, Ricardo J, Garcia, Catarina, Monteiro, Carlos M, Dinic, Jelena, Holmstedt, Suvi, André, Vânia, Pesic, Milica, dos Santos, Daniel J. V. A, Candeias, Nuno R, Afonso, Carlos A. M, Rijo, Patrícia
Published in ACS medicinal chemistry letters (14.05.2020)
Published in ACS medicinal chemistry letters (14.05.2020)
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Journal Article
Urolithin B: Two-way attack on IAPP proteotoxicity with implications for diabetes
Raimundo, Ana F, Ferreira, Sofia, Pobre, Vânia, Lopes-da-Silva, Mafalda, Brito, José A, Dos Santos, Daniel J V A, Saraiva, Nuno, Dos Santos, Cláudia N, Menezes, Regina
Published in Frontiers in endocrinology (Lausanne) (15.12.2022)
Published in Frontiers in endocrinology (Lausanne) (15.12.2022)
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Journal Article
Incorporation of Basic Side Chains into Cryptolepine Scaffold: Structure−Antimalarial Activity Relationships and Mechanistic Studies
Lavrado, João, Cabal, Ghislain G, Prudêncio, Miguel, Mota, Maria M, Gut, Jiri, Rosenthal, Philip J, Díaz, Cecília, Guedes, Rita C, dos Santos, Daniel J. V. A, Bichenkova, Elena, Douglas, Kenneth T, Moreira, Rui, Paulo, Alexandra
Published in Journal of medicinal chemistry (10.02.2011)
Published in Journal of medicinal chemistry (10.02.2011)
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Journal Article
Toward a Better Pharmacophore Description of P-Glycoprotein Modulators, Based on Macrocyclic Diterpenes from Euphorbia Species
Ferreira, Ricardo J, dos Santos, Daniel J. V. A, Ferreira, Maria-José U, Guedes, Rita C
Published in Journal of chemical information and modeling (27.06.2011)
Published in Journal of chemical information and modeling (27.06.2011)
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Journal Article