Fosmetpantotenate (RE-024), a phosphopantothenate replacement therapy for pantothenate kinase-associated neurodegeneration: Mechanism of action and efficacy in nonclinical models
Elbaum, Daniel, Beconi, Maria G, Monteagudo, Edith, Di Marco, Annalise, Quinton, Maria S, Lyons, Kathryn A, Vaino, Andrew, Harper, Steven
Published in PloS one (09.03.2018)
Published in PloS one (09.03.2018)
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PEGylation of Neuromedin U yields a promising candidate for the treatment of obesity and diabetes
Ingallinella, Paolo, Peier, Andrea M., Pocai, Alessandro, Marco, Annalise Di, Desai, Kunal, Zytko, Karolina, Qian, Ying, Du, Xiaobing, Cellucci, Antonella, Monteagudo, Edith, Laufer, Ralph, Bianchi, Elisabetta, Marsh, Donald J., Pessi, Antonello
Published in Bioorganic & medicinal chemistry (01.08.2012)
Published in Bioorganic & medicinal chemistry (01.08.2012)
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Journal Article
Efficacy of PEGylated ciliary neurotrophic factor superagonist variant in diet-induced obesity mice
Battista, Maria Rosaria, Grigoletto, Antonella, Tedeschini, Tommaso, Cellucci, Antonella, Colaceci, Fabrizio, Laufer, Ralph, Pasut, Gianfranco, Di Marco, Annalise
Published in PloS one (22.03.2022)
Published in PloS one (22.03.2022)
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Modelling the Human Blood–Brain Barrier in Huntington Disease
Vignone, Domenico, Gonzalez Paz, Odalys, Fini, Ivan, Cellucci, Antonella, Auciello, Giulio, Battista, Maria Rosaria, Gloaguen, Isabelle, Fortuni, Silvia, Cariulo, Cristina, Khetarpal, Vinod, Dominguez, Celia, Muñoz-Sanjuán, Ignacio, Di Marco, Annalise
Published in International journal of molecular sciences (15.07.2022)
Published in International journal of molecular sciences (15.07.2022)
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Journal Article
DEVELOPMENT AND VALIDATION OF A HIGH-THROUGHPUT RADIOMETRIC CYP3A4/5 INHIBITION ASSAY USING TRITIATED TESTOSTERONE
Annalise Di Marco, Isabella Marcucci, Maria Verdirame, José Pérez, Manuel Sanchez, Fernando Peláez, Ashok Chaudhary, Ralph Laufer
Published in Drug metabolism and disposition (01.03.2005)
Published in Drug metabolism and disposition (01.03.2005)
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Journal Article
Application of an in Vitro Blood–Brain Barrier Model in the Selection of Experimental Drug Candidates for the Treatment of Huntington’s Disease
Di Marco, Annalise, Gonzalez Paz, Odalys, Fini, Ivan, Vignone, Domenico, Cellucci, Antonella, Battista, Maria Rosaria, Auciello, Giulio, Orsatti, Laura, Zini, Matteo, Monteagudo, Edith, Khetarpal, Vinod, Rose, Mark, Dominguez, Celia, Herbst, Todd, Toledo-Sherman, Leticia, Summa, Vincenzo, Muñoz-Sanjuán, Ignacio
Published in Molecular pharmaceutics (06.05.2019)
Published in Molecular pharmaceutics (06.05.2019)
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Discovery of 2-(1H-imidazo-2-yl)piperazines as a new class of potent and non-cytotoxic inhibitors of Trypanosoma brucei growth in vitro
Ferrigno, Federica, Biancofiore, Ilaria, Malancona, Savina, Ponzi, Simona, Paonessa, Giacomo, Graziani, Rita, Bresciani, Alberto, Gennari, Nadia, Di Marco, Annalise, Kaiser, Marcel, Summa, Vincenzo, Harper, Steven, Ontoria, Jesus M.
Published in Bioorganic & medicinal chemistry letters (15.12.2018)
Published in Bioorganic & medicinal chemistry letters (15.12.2018)
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Journal Article
Synthesis and Biological Evaluation of RGD⁻Cryptophycin Conjugates for Targeted Drug Delivery
Borbély, Adina, Figueras, Eduard, Martins, Ana, Esposito, Simone, Auciello, Giulio, Monteagudo, Edith, Di Marco, Annalise, Summa, Vincenzo, Cordella, Paola, Perego, Raffaella, Kemker, Isabell, Frese, Marcel, Gallinari, Paola, Steinkühler, Christian, Sewald, Norbert
Published in Pharmaceutics (01.04.2019)
Published in Pharmaceutics (01.04.2019)
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Establishment of an in Vitro Human Blood-Brain Barrier Model Derived from Induced Pluripotent Stem Cells and Comparison to a Porcine Cell-Based System
Di Marco, Annalise, Vignone, Domenico, Gonzalez Paz, Odalys, Fini, Ivan, Battista, Maria Rosaria, Cellucci, Antonella, Bracacel, Elena, Auciello, Giulio, Veneziano, Maria, Khetarpal, Vinod, Rose, Mark, Rosa, Alessandro, Gloaguen, Isabelle, Monteagudo, Edith, Herbst, Todd, Dominguez, Celia, Muñoz-Sanjuán, Ignacio
Published in Cells (Basel, Switzerland) (16.04.2020)
Published in Cells (Basel, Switzerland) (16.04.2020)
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Journal Article
Quantitative Prediction of Human Clearance Guiding the Development of Raltegravir (MK-0518, Isentress) and Related HIV Integrase Inhibitors
LAUFER, Ralph, GONZALEZ PAZ, Odalys, DI MARCO, Annalise, BONELLI, Fabio, MONTEAGUDO, Edith, SUMMA, Vincenzo, ROWLEY, Michael
Published in Drug metabolism and disposition (01.04.2009)
Published in Drug metabolism and disposition (01.04.2009)
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Journal Article
Synthesis and evaluation of novel phosphoramidate prodrugs of 2′-methyl cytidine as inhibitors of hepatitis c virus NS5B polymerase
Donghi, Monica, Attenni, Barbara, Gardelli, Cristina, Marco, Annalise Di, Fiore, Fabrizio, Giuliano, Claudio, Laufer, Ralph, Leone, Joseph F., Pucci, Vincenzo, Rowley, Michael, Narjes, Frank
Published in Bioorganic & medicinal chemistry letters (01.03.2009)
Published in Bioorganic & medicinal chemistry letters (01.03.2009)
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Journal Article
Enhancing B- and T-Cell Immune Response to a Hepatitis C Virus E2 DNA Vaccine by Intramuscular Electrical Gene Transfer
Zucchelli, S, Capone, S, Fattori, E, Folgori, A, Di Marco, A, Casimiro, D, Simon, A J, Laufer, R, La Monica, N, Cortese, R, Nicosia, A
Published in Journal of Virology (01.12.2000)
Published in Journal of Virology (01.12.2000)
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Journal Article
Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance
Gloaguen, I. (IRBM, Rome, Italy.), Costa, P, Demartis, A, Lazzaro, D, Di Marco, A, Graziani, R, Paonessa, G, Chen, F, Rosenblum, C.I, Ploeg, L.H.T. van der
Published in Proceedings of the National Academy of Sciences - PNAS (10.06.1997)
Published in Proceedings of the National Academy of Sciences - PNAS (10.06.1997)
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Journal Article
Transport of cationic liposomes in a human blood brain barrier model: Role of the stereochemistry of the gemini amphiphile on liposome biological features
Simonis, Beatrice, Vignone, Domenico, Gonzalez Paz, Odalys, Donati, Enrica, Falchetti, Maria Laura, Bombelli, Cecilia, Cellucci, Antonella, Auciello, Giulio, Fini, Ivan, Galantini, Luciano, Syeda, Rudaba Zaman, Mazzonna, Marco, Mongiardi, Maria Patrizia, Buonocore, Francesco, Ceccacci, Francesca, Di Marco, Annalise, Mancini, Giovanna
Published in Journal of colloid and interface science (01.12.2022)
Published in Journal of colloid and interface science (01.12.2022)
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Journal Article
Design, Synthesis, and Biological Evaluation of New 1-(Aryl-1H-pyrrolyl)(phenyl)methyl-1H-innidazole Derivatives as Antiprotozoal Agents
Saccoliti, Francesco, Madia, Valentina Noemi, Tudino, Valeria, De Leo, Alessandro, Pescatori, Luca, Messore, Antonella, De Vita, Daniela, Scipione, Luigi, Brun, Reto, Kaiser, Marcel, Maser, Pascal, Calvet, Claudia M., Jennings, Gareth K., Podust, Larissa M., Pepe, Giacomo, Cirilli, Roberto, Faggi, Cristina, Di Marco, Annalise, Battista, Maria Rosaria, Summa, Vincenzo, Costi, Roberta, Di Santo, Roberto
Published in Journal of medicinal chemistry (14.02.2019)
Published in Journal of medicinal chemistry (14.02.2019)
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Journal Article
Cyclic Phosphopantothenic Acid Prodrugs for Treatment of Pantothenate Kinase-Associated Neurodegeneration
Auciello, Giulio, Di Marco, Annalise, Gonzalez Paz, Odalys, Malancona, Savina, Harper, Steven, Beconi, Maria, Rossetti, Ilaria, Ciammaichella, Alina, Fezzardi, Paola, Vecchi, Andrea, Bracacel, Elena, Cicero, Daniel, Monteagudo, Edith, Elbaum, Daniel
Published in Journal of medicinal chemistry (24.12.2020)
Published in Journal of medicinal chemistry (24.12.2020)
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Journal Article
Fosmetpantotenate
Elbaum, Daniel, Beconi, Maria G, Monteagudo, Edith, Di Marco, Annalise, Quinton, Maria S, Lyons, Kathryn A, Vaino, Andrew, Harper, Steven
Published in PloS one (09.03.2018)
Published in PloS one (09.03.2018)
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Journal Article