T lymphocytes need less than 3 min to discriminate between peptide MHCs with similar TCR‐binding parameters
Brodovitch, Alexandre, Shenderov, Eugene, Cerundolo, Vincenzo, Bongrand, Pierre, Pierres, Anne, der Merwe, Philip Anton
Published in European journal of immunology (01.06.2015)
Published in European journal of immunology (01.06.2015)
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Ligand requirements for immunoreceptor triggering
Barton, Michael I, Paterson, Rachel L, Denham, Eleanor M, Goyette, Jesse, van der Merwe, Philip Anton
Published in Communications biology (13.09.2024)
Published in Communications biology (13.09.2024)
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Matched sizes of activating and inhibitory receptor/ligand pairs are required for optimal signal integration by human natural killer cells
Köhler, Karsten, Xiong, Shiqiu, Brzostek, Joanna, Mehrabi, Maryam, Eissmann, Philipp, Harrison, Alice, Cordoba, Shaun-Paul, Oddos, Stephane, Miloserdov, Vladimir, Gould, Keith, Burroughs, Nigel J, van der Merwe, Philip Anton, Davis, Daniel M
Published in PloS one (05.11.2010)
Published in PloS one (05.11.2010)
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TCR–pMHC kinetics under force in a cell-free system show no intrinsic catch bond, but a minimal encounter duration before binding
Limozin, Laurent, Bridge, Marcus, Bongrand, Pierre, Dushek, Omer, van der Merwe, Philip Anton, Robert, Philippe
Published in Proceedings of the National Academy of Sciences - PNAS (20.08.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (20.08.2019)
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Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose
Lever, Melissa, Lim, Hong-Sheng, Kruger, Philipp, Nguyen, John, Trendel, Nicola, Abu-Shah, Enas, Maini, Philip Kumar, van der Merwe, Philip Anton, Dushek, Omer
Published in Proceedings of the National Academy of Sciences - PNAS (25.10.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (25.10.2016)
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Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation
Dushek, Omer, Aleksic, Milos, Wheeler, Richard J, Zhang, Hao, Cordoba, Shaun-Paul, Peng, Yan-Chun, Chen, Ji-Li, Cerundolo, Vincenzo, Dong, Tao, Coombs, Daniel, van der Merwe, P Anton
Published in Science signaling (07.06.2011)
Published in Science signaling (07.06.2011)
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Why do some T cell receptor cytoplasmic domains associate with the plasma membrane?
van der Merwe, P Anton, Zhang, Hao, Cordoba, Shaun-Paul
Published in Frontiers in immunology (01.01.2012)
Published in Frontiers in immunology (01.01.2012)
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Journal Article
Ligand requirements for immunoreceptor triggering
Barton, Michael I, Paterson, Rachel L, Denham, Eleanor M, Goyette, Jesse, Philip Anton Van Der Merwe
Published in bioRxiv (09.12.2023)
Published in bioRxiv (09.12.2023)
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Mechanical forces impair antigen discrimination by reducing differences in T cell receptor off-rates
Pettmann, Johannes, Awada, Lama, Rozycki, Bartosz, Huhn, Anna, Faour, Sara, Kutuzov, Mikhail A, Limozin, Laurent, Weikl, Thomas R, Philip Anton Van Der Merwe, Philippe, Robert, Dushek, Omer
Published in bioRxiv (05.05.2022)
Published in bioRxiv (05.05.2022)
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Architecture of a minimal signalling pathway explains the T cell response to a 1,000,000-fold variation in antigen affinity and dose
Lever, Melissa, Hong-Sheng, Lim, Kruger, Philipp, Nguyen, John, Trendel, Nicola, Abu-Shah, Enas, Maini, Philip K, Philip Anton Van Der Merwe, Dushek, Omer
Published in bioRxiv (27.08.2016)
Published in bioRxiv (27.08.2016)
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