Mechanistic incorporation of FcRn binding in plasma and endosomes in a whole body PBPK model for large molecules
de Witte, Wilhelmus E. A., Avery, Lindsay B., Mackness, Brian C., Van Bogaert, Tom, Park, Anna, Sargentini-Maier, Maria Laura
Published in Journal of pharmacokinetics and pharmacodynamics (01.06.2023)
Published in Journal of pharmacokinetics and pharmacodynamics (01.06.2023)
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Journal Article
A novel CCR2 antagonist inhibits atherogenesis in apoE deficient mice by achieving high receptor occupancy
Bot, Ilze, Ortiz Zacarías, Natalia V., de Witte, Wilhelmus E. A., de Vries, Henk, van Santbrink, Peter J., van der Velden, Daniël, Kröner, Mara J., van der Berg, Dirk-Jan, Stamos, Dean, de Lange, Elizabeth C. M., Kuiper, Johan, IJzerman, Adriaan P., Heitman, Laura H.
Published in Scientific reports (03.03.2017)
Published in Scientific reports (03.03.2017)
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Journal Article
Novel CNS drug discovery and development approach: model-based integration to predict neuro-pharmacokinetics and pharmacodynamics
de Lange, Elizabeth C. M., van den Brink, Willem, Yamamoto, Yumi, de Witte, Wilhelmus E. A., Wong, Yin Cheong
Published in Expert opinion on drug discovery (02.12.2017)
Published in Expert opinion on drug discovery (02.12.2017)
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Journal Article
In vitro and in silico analysis of the effects of D2 receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations
Witte, Wilhelmus E A, Versfelt, Joost W, Kuzikov, Maria, Rolland, Solene, Georgi, Victoria, Gribbon, Philip, Gul, Sheraz, Huntjens, Dymphy, Graaf, Piet Hein, Danhof, Meindert, Fernández‐Montalván, Amaury, Witt, Gesa, Lange, Elizabeth C M
Published in British journal of pharmacology (01.11.2018)
Published in British journal of pharmacology (01.11.2018)
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Journal Article
Target and Tissue Selectivity Prediction by Integrated Mechanistic Pharmacokinetic-Target Binding and Quantitative Structure Activity Modeling
Vlot, Anna H. C., de Witte, Wilhelmus E. A., Danhof, Meindert, van der Graaf, Piet H., van Westen, Gerard J. P., de Lange, Elizabeth C. M.
Published in The AAPS journal (04.12.2017)
Published in The AAPS journal (04.12.2017)
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Journal Article
Correction to: Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models
de Witte, Wilhelmus E. A., Rottschäfer, Vivi, Danhof, Meindert, van der Graaf, Piet H., Peletier, Lambertus A., de Lange, Elizabeth C. M.
Published in Journal of pharmacokinetics and pharmacodynamics (01.10.2018)
Published in Journal of pharmacokinetics and pharmacodynamics (01.10.2018)
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Journal Article
Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models
de Witte, Wilhelmus E. A., Rottschäfer, Vivi, Danhof, Meindert, van der Graaf, Piet H., Peletier, Lambertus A., de Lange, Elizabeth C. M.
Published in Journal of pharmacokinetics and pharmacodynamics (01.08.2018)
Published in Journal of pharmacokinetics and pharmacodynamics (01.08.2018)
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Journal Article
Mechanistic models enable the rational use of in vitro drug-target binding kinetics for better drug effects in patients
de Witte, Wilhelmus E A, Wong, Yin Cheong, Nederpelt, Indira, Heitman, Laura H, Danhof, Meindert, van der Graaf, Piet H, Gilissen, Ron A H J, de Lange, Elizabeth C M
Published in Expert opinion on drug discovery (02.01.2016)
Published in Expert opinion on drug discovery (02.01.2016)
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Journal Article
In vitro and in silico analysis of the effects of D 2 receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations
de Witte, Wilhelmus E A, Versfelt, Joost W, Kuzikov, Maria, Rolland, Solene, Georgi, Victoria, Gribbon, Philip, Gul, Sheraz, Huntjens, Dymphy, van der Graaf, Piet Hein, Danhof, Meindert, Fernández-Montalván, Amaury, Witt, Gesa, de Lange, Elizabeth C M
Published in British journal of pharmacology (01.11.2018)
Published in British journal of pharmacology (01.11.2018)
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Journal Article