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Biophysical Mechanisms of Endotoxin Neutralization by Cationic Amphiphilic Peptides

Biophysical Mechanisms of Endotoxin Neutralization by Cationic Amphiphilic Peptides

by Kaconis, Yani, Kowalski, Ina, Howe, Jörg, Brauser, Annemarie, Richter, Walter, Razquin-Olazarán, Iosu, Iñigo-Pestaña, Melania, Garidel, Patrick, Rössle, Manfred, Martinez de Tejada, Guillermo, Gutsmann, Thomas, Brandenburg, Klaus
Published in Biophysical journal (08.06.2011)

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Bacterial cell wall compounds as promising targets of antimicrobial agents I. Antimicrobial peptides and lipopolyamines

Bacterial cell wall compounds as promising targets of antimicrobial agents I. Antimicrobial peptides and lipopolyamines

by Martínez de Tejada, Guillermo, Sánchez-Gómez, Susana, Rázquin-Olazaran, Iosu, Kowalski, Ina, Kaconis, Yani, Heinbockel, Lena, Andrä, Jörg, Schürholz, Tobias, Hornef, Mathias, Dupont, Aline, Garidel, Patrick, Lohner, Karl, Gutsmann, Thomas, David, Sunil A, Brandenburg, Klaus
Published in Current drug targets (01.08.2012)

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Structural Features Governing the Activity of Lactoferricin-Derived Peptides That Act in Synergy with Antibiotics against Pseudomonas aeruginosa In Vitro and In Vivo

Structural Features Governing the Activity of Lactoferricin-Derived Peptides That Act in Synergy with Antibiotics against Pseudomonas aeruginosa In Vitro and In Vivo

by SANCHEZ-GOMEZ, Susana, JAPELJ, Bostjan, MARTINEZ DE TEJADA, Guillermo, JERALA, Roman, MORIYON, Ignacio, FERNANDEZ ALONSO, Mirian, LEIVA, José, BLONDELLE, Sylvie E, ANDRÄ, Jörg, BRANDENBURG, Klaus, LOHNER, Karl
Published in Antimicrobial Agents and Chemotherapy (01.01.2011)

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Antimicrobial endotoxin‐neutralizing peptides promote keratinocyte migration via P2X7 receptor activation and accelerate wound healing in vivo

Antimicrobial endotoxin‐neutralizing peptides promote keratinocyte migration via P2X7 receptor activation and accelerate wound healing in vivo

by Pfalzgraff, Anja, Bárcena‐Varela, Sergio, Heinbockel, Lena, Gutsmann, Thomas, Brandenburg, Klaus, Martinez‐de‐Tejada, Guillermo, Weindl, Günther
Published in British journal of pharmacology (01.09.2018)

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Anti-Infective and Anti-Inflammatory Mode of Action of Peptide 19-2.5

Anti-Infective and Anti-Inflammatory Mode of Action of Peptide 19-2.5

by Heinbockel, Lena, Weindl, Günther, Correa, Wilmar, Brandenburg, Julius, Reiling, Norbert, Wiesmüller, Karl-Heinz, Schürholz, Tobias, Gutsmann, Thomas, Martinez de Tejada, Guillermo, Mauss, Karl, Brandenburg, Klaus
Published in International journal of molecular sciences (02.02.2021)

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Preclinical Investigations Reveal the Broad-Spectrum Neutralizing Activity of Peptide Pep19-2.5 on Bacterial Pathogenicity Factors

Preclinical Investigations Reveal the Broad-Spectrum Neutralizing Activity of Peptide Pep19-2.5 on Bacterial Pathogenicity Factors

by HEINBOCKEL, Lena, SANCHEZ-GOMEZ, Susana, ERNST, Martin, GUTSMANN, Thomas, SCHÜRHOLZ, Tobias, BRANDENBURG, Klaus, MARTINEZ DE TEJADA, Guillermo, DÖMMING, Sabine, BRANDENBURG, Julius, KACONIS, Yani, HORNEF, Mathias, DUPONT, Aline, MARWITZ, Sebastian, GOLDMANN, Torsten
Published in Antimicrobial Agents and Chemotherapy (01.03.2013)

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New Antiseptic Peptides To Protect against Endotoxin-Mediated Shock

New Antiseptic Peptides To Protect against Endotoxin-Mediated Shock

by Gutsmann, Thomas, Razquin-Olazarán, Iosu, Kowalski, Ina, Kaconis, Yani, Howe, Jörg, Bartels, Rainer, Hornef, Mathias, Schürholz, Tobias, Rössle, Manfred, Sanchez-Gómez, Susana, Moriyon, Ignacio, Martinez de Tejada, Guillermo, Brandenburg, Klaus
Published in Antimicrobial Agents and Chemotherapy (01.09.2010)

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Therapeutical Administration of Peptide Pep19-2.5 and Ibuprofen Reduces Inflammation and Prevents Lethal Sepsis

Therapeutical Administration of Peptide Pep19-2.5 and Ibuprofen Reduces Inflammation and Prevents Lethal Sepsis

by Heinbockel, Lena, Marwitz, Sebastian, Barcena Varela, Sergio, Ferrer-Espada, Raquel, Reiling, Norbert, Goldmann, Torsten, Gutsmann, Thomas, Mier, Walter, Schürholz, Tobias, Drömann, Daniel, Brandenburg, Klaus, Martinez de Tejada, Guillermo
Published in PloS one (21.07.2015)

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Rationale for the Design of Shortened Derivatives of the NK-lysin-derived Antimicrobial Peptide NK-2 with Improved Activity against Gram-negative Pathogens

Rationale for the Design of Shortened Derivatives of the NK-lysin-derived Antimicrobial Peptide NK-2 with Improved Activity against Gram-negative Pathogens

by Andraö, Joörg, Monreal, Daniel, de Tejada, Guillermo Martinez, Olak, Claudia, Brezesinski, Gerald, Gomez, Susana Sanchez, Goldmann, Torsten, Bartels, Rainer, Brandenburg, Klaus, Moriyon, Ignacio
Published in The Journal of biological chemistry (18.05.2007)

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Free Thiol Group of MD-2 as the Target for Inhibition of the Lipopolysaccharide-induced Cell Activation

Free Thiol Group of MD-2 as the Target for Inhibition of the Lipopolysaccharide-induced Cell Activation

by Manček-Keber, Mateja, Gradišar, Helena, Pestaña, Melania Iñigo, de Tejada, Guillermo Martinez, Jerala, Roman
Published in The Journal of biological chemistry (17.07.2009)

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Implementation and Characterization of a Fully Miniaturized Biosensor for Endotoxin Detection Based on Electrochemical Techniques

Implementation and Characterization of a Fully Miniaturized Biosensor for Endotoxin Detection Based on Electrochemical Techniques

by Zuzuarregui, Ana, Morant-Minana, Maria Carmen, Perez-Lorenzo, Eva, Martinez de Tejada, Guillermo, Arana, Sergio, Mujika, Maite
Published in IEEE sensors journal (01.01.2014)

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A permeability-increasing drug synergizes with bacterial efflux pump inhibitors and restores susceptibility to antibiotics in multi-drug resistant Pseudomonas aeruginosa strains

A permeability-increasing drug synergizes with bacterial efflux pump inhibitors and restores susceptibility to antibiotics in multi-drug resistant Pseudomonas aeruginosa strains

by Ferrer-Espada, Raquel, Shahrour, Hawraa, Pitts, Betsey, Stewart, Philip S, Sánchez-Gómez, Susana, Martínez-de-Tejada, Guillermo
Published in Scientific reports (05.03.2019)

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Bacterial cell wall compounds as promising targets of antimicrobial agents II. Immunological and clinical aspects

Bacterial cell wall compounds as promising targets of antimicrobial agents II. Immunological and clinical aspects

by Schuerholz, Tobias, Dömming, Sabine, Hornef, Mathias, Dupont, Aline, Kowalski, Ina, Kaconis, Yani, Heinbockel, Lena, Andrä, Jörg, Garidel, Patrick, Gutsmann, Thomas, David, Sunil, Sánchez-Gómez, Susana, Martinez de Tejada, Guillermo, Brandenburg, Klaus
Published in Current drug targets (01.08.2012)

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Permeability enhancers sensitize β-lactamase-expressing Enterobacteriaceae and Pseudomonas aeruginosa to β-lactamase inhibitors, thereby restoring their β-lactam susceptibility

Permeability enhancers sensitize β-lactamase-expressing Enterobacteriaceae and Pseudomonas aeruginosa to β-lactamase inhibitors, thereby restoring their β-lactam susceptibility

by Ferrer-Espada, Raquel, Sánchez-Gómez, Susana, Pitts, Betsey, Stewart, Philip S., Martínez-de-Tejada, Guillermo
Published in International journal of antimicrobial agents (01.07.2020)

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AMPs as Anti-biofilm Agents for Human Therapy and Prophylaxis

AMPs as Anti-biofilm Agents for Human Therapy and Prophylaxis

by Shahrour, Hawraa, Ferrer-Espada, Raquel, Dandache, Israa, Bárcena-Varela, Sergio, Sánchez-Gómez, Susana, Chokr, Ali, Martinez-de-Tejada, Guillermo
Published in Advances in experimental medicine and biology (2019)

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A Comparison between SARS-CoV-2 and Gram-Negative Bacteria-Induced Hyperinflammation and Sepsis

A Comparison between SARS-CoV-2 and Gram-Negative Bacteria-Induced Hyperinflammation and Sepsis

by Brandenburg, Klaus, Ferrer-Espada, Raquel, Martinez-de-Tejada, Guillermo, Nehls, Christian, Fukuoka, Satoshi, Mauss, Karl, Weindl, Günther, Garidel, Patrick
Published in International journal of molecular sciences (01.10.2023)

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Inhibition of Lipopolysaccharide- and Lipoprotein-Induced Inflammation by Antitoxin Peptide Pep19-2.5

Inhibition of Lipopolysaccharide- and Lipoprotein-Induced Inflammation by Antitoxin Peptide Pep19-2.5

by Heinbockel, Lena, Weindl, Günther, Martinez-de-Tejada, Guillermo, Correa, Wilmar, Sanchez-Gomez, Susana, Bárcena-Varela, Sergio, Goldmann, Torsten, Garidel, Patrick, Gutsmann, Thomas, Brandenburg, Klaus
Published in Frontiers in immunology (26.07.2018)

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Supramolecular assembly of micellar aggregates is the basis of low endotoxin recovery (LER) in a drug formulation that can be resolved by a whole blood assay

Supramolecular assembly of micellar aggregates is the basis of low endotoxin recovery (LER) in a drug formulation that can be resolved by a whole blood assay

by Schromm, Andra B., Correa, Wilmar, Gisch, Nicolas, Steiniger, Frank, Richter, Walter, Martinez-de-Tejada, Guillermo, Brandenburg, Klaus, von Wintzingerode, Friedrich
Published in Biomedicine & pharmacotherapy (01.04.2024)

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Lipoproteins/peptides are sepsis-inducing toxins from bacteria that can be neutralized by synthetic anti-endotoxin peptides

Lipoproteins/peptides are sepsis-inducing toxins from bacteria that can be neutralized by synthetic anti-endotoxin peptides

by Martinez de Tejada, Guillermo, Heinbockel, Lena, Ferrer-Espada, Raquel, Heine, Holger, Alexander, Christian, Bárcena-Varela, Sergio, Goldmann, Torsten, Correa, Wilmar, Wiesmüller, Karl-Heinz, Gisch, Nicolas, Sánchez-Gómez, Susana, Fukuoka, Satoshi, Schürholz, Tobias, Gutsmann, Thomas, Brandenburg, Klaus
Published in Scientific reports (22.09.2015)

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Antimicrobial Peptides as Anti-biofilm Agents in Medical Implants

Antimicrobial Peptides as Anti-biofilm Agents in Medical Implants

by Sánchez-Gómez, Susana, Martínez-de-Tejada, Guillermo
Published in Current topics in medicinal chemistry (01.02.2017)

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