Comparison of the cancer gene targeting and biochemical selectivities of all targeted kinase inhibitors approved for clinical use
Uitdehaag, Joost C M, de Roos, Jeroen A D M, van Doornmalen, Antoon M, Prinsen, Martine B W, de Man, Jos, Tanizawa, Yoshinori, Kawase, Yusuke, Yoshino, Kohichiro, Buijsman, Rogier C, Zaman, Guido J R
Published in PloS one (20.03.2014)
Published in PloS one (20.03.2014)
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Selective Targeting of CTNBB1-, KRAS- or MYC-Driven Cell Growth by Combinations of Existing Drugs
Uitdehaag, Joost C M, de Roos, Jeroen A D M, van Doornmalen, Antoon M, Prinsen, Martine B W, Spijkers-Hagelstein, Jill A P, de Vetter, Judith R F, de Man, Jos, Buijsman, Rogier C, Zaman, Guido J R
Published in PloS one (27.05.2015)
Published in PloS one (27.05.2015)
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Journal Article
Chromosomal instability, tolerance of mitotic errors and multidrug resistance are promoted by tetraploidization in human cells
Kuznetsova, Anastasia Y, Seget, Katarzyna, Moeller, Giuliana K, de Pagter, Mirjam S, de Roos, Jeroen A D M, Dürrbaum, Milena, Kuffer, Christian, Müller, Stefan, Zaman, Guido J R, Kloosterman, Wigard P, Storchová, Zuzana
Published in Cell cycle (Georgetown, Tex.) (2015)
Published in Cell cycle (Georgetown, Tex.) (2015)
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Journal Article
Comparative kinase and cancer cell panel profiling of kinase inhibitors approved for clinical use from 2018 to 2020
Kooijman, Jeffrey J, van Riel, Wilhelmina E, Dylus, Jelle, Prinsen, Martine B W, Grobben, Yvonne, de Bitter, Tessa J J, van Doornmalen, Antoon M, Melis, Janneke J T M, Uitdehaag, Joost C M, Narumi, Yugo, Kawase, Yusuke, de Roos, Jeroen A D M, Willemsen-Seegers, Nicole, Zaman, Guido J R
Published in Frontiers in oncology (14.09.2022)
Published in Frontiers in oncology (14.09.2022)
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Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity
Uitdehaag, Joost C.M., de Man, Jos, Willemsen-Seegers, Nicole, Prinsen, Martine B.W., Libouban, Marion A.A., Sterrenburg, Jan Gerard, de Wit, Joeri J.P., de Vetter, Judith R.F., de Roos, Jeroen A.D.M., Buijsman, Rogier C., Zaman, Guido J.R.
Published in Journal of molecular biology (07.07.2017)
Published in Journal of molecular biology (07.07.2017)
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Journal Article
TTK Inhibitors as a Targeted Therapy for CTNNB1 ( β -catenin) Mutant Cancers
Zaman, Guido J R, de Roos, Jeroen A D M, Libouban, Marion A A, Prinsen, Martine B W, de Man, Jos, Buijsman, Rogier C, Uitdehaag, Joost C M
Published in Molecular cancer therapeutics (01.11.2017)
Published in Molecular cancer therapeutics (01.11.2017)
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Journal Article
Combined Cellular and Biochemical Profiling to Identify Predictive Drug Response Biomarkers for Kinase Inhibitors Approved for Clinical Use between 2013 and 2017
Uitdehaag, Joost C M, Kooijman, Jeffrey J, de Roos, Jeroen A D M, Prinsen, Martine B W, Dylus, Jelle, Willemsen-Seegers, Nicole, Kawase, Yusuke, Sawa, Masaaki, de Man, Jos, van Gerwen, Suzanne J C, Buijsman, Rogier C, Zaman, Guido J R
Published in Molecular cancer therapeutics (01.02.2019)
Published in Molecular cancer therapeutics (01.02.2019)
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Journal Article
Cell Panel Profiling Reveals Conserved Therapeutic Clusters and Differentiates the Mechanism of Action of Different PI3K/mTOR, Aurora Kinase and EZH2 Inhibitors
Uitdehaag, Joost C M, de Roos, Jeroen A D M, Prinsen, Martine B W, Willemsen-Seegers, Nicole, de Vetter, Judith R F, Dylus, Jelle, van Doornmalen, Antoon M, Kooijman, Jeffrey, Sawa, Masaaki, van Gerwen, Suzanne J C, de Man, Jos, Buijsman, Rogier C, Zaman, Guido J R
Published in Molecular cancer therapeutics (01.12.2016)
Published in Molecular cancer therapeutics (01.12.2016)
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Journal Article
Stable aneuploid tumors cells are more sensitive to TTK inhibition than chromosomally unstable cell lines
Libouban, Marion A A, de Roos, Jeroen A D M, Uitdehaag, Joost C M, Willemsen-Seegers, Nicole, Mainardi, Sara, Dylus, Jelle, de Man, Jos, Tops, Bastiaan, Meijerink, Jules P P, Storchová, Zuzana, Buijsman, Rogier C, Medema, René H, Zaman, Guido J R
Published in Oncotarget (13.06.2017)
Published in Oncotarget (13.06.2017)
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Journal Article
Selective Targeting of CTNNB1-, KRAS- or MYC-Driven Cell Growth by Combinations of Existing Drugs
Uitdehaag, Joost C. M., de Roos, Jeroen A. D. M., van Doornmalen, Antoon M., Prinsen, Martine B. W., Spijkers-Hagelstein, Jill A. P., de Vetter, Judith R. F., de Man, Jos, Buijsman, Rogier C., Zaman, Guido J. R.
Published in PloS one (01.05.2015)
Published in PloS one (01.05.2015)
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Journal Article
Cryopreserved cells facilitate cell-based drug discovery
Zaman, Guido J.R., de Roos, Jeroen A.D.M., Blomenröhr, Marion, van Koppen, Chris J., Oosterom, Julia
Published in Drug discovery today (01.07.2007)
Published in Drug discovery today (01.07.2007)
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Journal Article
Abstract 1480: Comparative cancer cell panel profiling of kinase inhibitors approved for clinical use from 2018 to 2020
Kooijman, Jeffrey J., van Riel, Wilhelmina E., Prinsen, Martine B., Dylus, Jelle, de Roos, Jeroen A., Grobben, Yvonne, Willemsen-Seegers, Nicole, Muller, Michelle, de Man, Jos, Narumi, Yugo, Kawase, Yusuke, Buijsman, Rogier C., van Gerwen, Suzanne J., Zaman, Guido J.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Abstract 7126: Synergistic combinations and tissue type-specificity of compounds targeting components of the DNA damage response pathway in 2D culture and 3D spheroid cell viability assays
Melis, Janneke J., Kluitmans, Daphne J., Kooijman, Jeffrey J., Dylus, Jelle, Wetemans, Sabine, Geerdink-Datema, Suzan, de Roos, Jeroen A., Grobben, Yvonne, Zaman, Guido J.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Abstract 620: Screening of small-molecule MAPK pathway inhibitors on a panel of 130 human cancer cell lines identifies determinants of response in RAS -mutant subgroups
Kooijman, Jeffrey J., Al Koerdi, Awan, Kluitmans, Daphne J., van den Bossche, Esmee, Dylus, Jelle, de Roos, Jeroen A., Melis, Janneke J., Zaman, Guido J.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Abstract 619: Comprehensive cell line profiling of monomer- and dimer-selective small molecule RAF inhibitors uncovers determinants of cellular responses
Kooijman, Jeffrey J., Koerdi, Awan Al, van der Leeuw, Sjoerd B., Kluitmans, Daphne J., van den Bossche, Esmee, Dylus, Jelle, de Roos, Jeroen A., Melis, Janneke J., Willemsen-Seegers, Nicole, Zaman, Guido J.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Cytotoxic effects of 110 reference compounds on HepG2 cells and for 60 compounds on HeLa, ECC-1 and CHO cells. II mechanistic assays on NAD(P)H, ATP and DNA contents
Schoonen, Willem G E J, de Roos, Jeroen A D M, Westerink, Walter M A, Débiton, Eric
Published in Toxicology in vitro (01.06.2005)
Published in Toxicology in vitro (01.06.2005)
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Journal Article
Cytotoxic effects of 100 reference compounds on Hep G2 and HeLa cells and of 60 compounds on ECC-1 and CHO cells. I Mechanistic assays on ROS, glutathione depletion and calcein uptake
Schoonen, Willem G.E.J., Westerink, Walter M.A., de Roos, Jeroen A.D.M., Débiton, Eric
Published in Toxicology in vitro (01.06.2005)
Published in Toxicology in vitro (01.06.2005)
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Journal Article
Chromosomal instability, tolerance of mitotic errors and multidrug resistance are promoted by tetraploidization in human cells
Kuznetsova, Anastasia Y, Seget, Katarzyna, Moeller, Giuliana K, de Pagter, Mirjam S., de Roos, Jeroen A D M, Dürrbaum, Milena, Kuffer, Christian, Müller, Stefan, Zaman, Guido J R, Kloosterman, Wigard P, Storchová, Zuzana
Published in Cell Cycle (02.09.2015)
Published in Cell Cycle (02.09.2015)
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