Synthesis, Biological Evaluation, and Molecular Modeling of Donepezil and N-[(5-(Benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine Hybrids as New Multipotent Cholinesterase/Monoamine Oxidase Inhibitors for the Treatment of Alzheimer’s Disease
Bolea, Irene, Juárez-Jiménez, Jordi, de los Rı́os, Cristóbal, Chioua, Mourad, Pouplana, Ramón, Luque, F. Javier, Unzeta, Mercedes, Marco-Contelles, José, Samadi, Abdelouahid
Published in Journal of medicinal chemistry (22.12.2011)
Published in Journal of medicinal chemistry (22.12.2011)
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Tacripyrines, the First Tacrine−Dihydropyridine Hybrids, as Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease
Marco-Contelles, José, León, Rafael, de los Ríos, Cristóbal, Samadi, Abdelouahid, Bartolini, Manuela, Andrisano, Vincenza, Huertas, Oscar, Barril, Xavier, Luque, F. Javier, Rodríguez-Franco, María I, López, Beatriz, López, Manuela G, García, Antonio G, do Carmo Carreiras, María, Villarroya, Mercedes
Published in Journal of medicinal chemistry (14.05.2009)
Published in Journal of medicinal chemistry (14.05.2009)
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A review of metal-catalyzed molecular damage: protection by melatonin
Romero, Alejandro, Ramos, Eva, de Los Ríos, Cristóbal, Egea, Javier, del Pino, Javier, Reiter, Russel J.
Published in Journal of pineal research (01.05.2014)
Published in Journal of pineal research (01.05.2014)
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The purinergic P2X7 receptor as a potential drug target to combat neuroinflammation in neurodegenerative diseases
Calzaferri, Francesco, Ruiz‐Ruiz, Cristina, Diego, Antonio M. G., Pascual, Ricardo, Méndez‐López, Iago, Cano‐Abad, María F., Maneu, Victoria, Ríos, Cristóbal, Gandía, Luis, García, Antonio G.
Published in Medicinal research reviews (01.11.2020)
Published in Medicinal research reviews (01.11.2020)
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Synthesis and Pharmacological Evaluation of Novel Non-nucleotide Purine Derivatives as P2X7 Antagonists for the Treatment of Neuroinflammation
Calzaferri, Francesco, Narros-Fernández, Paloma, de Pascual, Ricardo, de Diego, Antonio M.G, Nicke, Annette, Egea, Javier, García, Antonio G, de los Ríos, Cristóbal
Published in Journal of medicinal chemistry (25.02.2021)
Published in Journal of medicinal chemistry (25.02.2021)
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Increased expression of the ATP‐gated P2X7 receptor reduces responsiveness to anti‐convulsants during status epilepticus in mice
Beamer, Edward, Morgan, James, Alves, Mariana, Menéndez Méndez, Aida, Morris, Gareth, Zimmer, Béla, Conte, Giorgia, Diego‐Garcia, Laura, Alarcón‐Vila, Cristina, Yiu Ng, Nico Ka, Madden, Stephen, Calzaferri, Francesco, Ríos, Cristóbal, García, Antonio G., Hamacher, Michael, Dinkel, Klaus, Pelegrín, Pablo, Henshall, David C., Nicke, Annette, Engel, Tobias
Published in British journal of pharmacology (01.06.2022)
Published in British journal of pharmacology (01.06.2022)
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Benzothiazepine CGP37157 Analogues Exert Cytoprotection in Various in Vitro Models of Neurodegeneration
Martínez-Sanz, Francisco J, Lajarín-Cuesta, Rocío, Moreno-Ortega, Ana J, González-Lafuente, Laura, Fernández-Morales, Jose C, López-Arribas, Raquel, Cano-Abad, María F, Ríos, Cristóbal de los
Published in ACS chemical neuroscience (16.09.2015)
Published in ACS chemical neuroscience (16.09.2015)
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ITH12410/SC058: A New Neuroprotective Compound with Potential in the Treatment of Alzheimer’s Disease
Romero, Alejandro, Egea, Javier, González-Muñoz, Gema C, Martı́n de Saavedra, Ma Dolores, del Barrio, Laura, Rodríguez-Franco, María Isabel, Conde, Santiago, López, Manuela G, Villarroya, Mercedes, de los Ríos, Cristóbal
Published in ACS chemical neuroscience (17.09.2014)
Published in ACS chemical neuroscience (17.09.2014)
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In Silico Prediction of the Toxic Potential of Neuroprotective Bifunctional Molecules Based on Chiral N‑Propargyl-1,2-amino Alcohol Derivatives
Ramos, Eva, Lajarín-Cuesta, Rocío, Arribas, Raquel L, García-Frutos, Eva M, González-Lafuente, Laura, Egea, Javier, de los Ríos, Cristóbal, Romero, Alejandro
Published in Chemical research in toxicology (17.05.2021)
Published in Chemical research in toxicology (17.05.2021)
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Synthesis and Biological Assessment of 4,1-Benzothiazepines with Neuroprotective Activity on the Ca2+ Overload for the Treatment of Neurodegenerative Diseases and Stroke
Viejo, Lucía, Rubio-Alarcón, Marcos, Arribas, Raquel L., Moreno-Castro, Manuel, Pérez-Marín, Raquel, Braun-Cornejo, María, Estrada-Valencia, Martín, de los Ríos, Cristóbal
Published in Molecules (Basel, Switzerland) (24.07.2021)
Published in Molecules (Basel, Switzerland) (24.07.2021)
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The mitochondrial Na+/Ca2+ exchanger NCLX is implied in the activation of hypoxia-inducible factors
Choya-Foces, Carmen, Navarro, Elisa, Ríos, Cristóbal de los, López, Manuela G., Egea, Javier, Hernansanz-Agustín, Pablo, Martínez-Ruiz, Antonio
Published in Redox biology (01.11.2024)
Published in Redox biology (01.11.2024)
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Retinal response to systemic inflammation differs between sexes and neurons
Rodríguez-Ramírez, Kristy T, Norte-Muñoz, María, Lucas-Ruiz, Fernando, Gallego-Ortega, Alejandro, Calzaferri, Francesco, García-Bernal, David, Martínez, Carlos M, Galindo-Romero, Caridad, de Los Ríos, Cristóbal, Vidal-Sanz, Manuel, Agudo-Barriuso, Marta
Published in Frontiers in immunology (07.02.2024)
Published in Frontiers in immunology (07.02.2024)
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Synthesis, Inhibitory Activity of Cholinesterases, and Neuroprotective Profile of Novel 1,8-Naphthyridine Derivatives
de los Ríos, Cristóbal, Egea, Javier, Marco-Contelles, José, León, Rafael, Samadi, Abdelouahid, Iriepa, Isabel, Moraleda, Ignacio, Gálvez, Enrique, García, Antonio G, López, Manuela G, Villarroya, Mercedes, Romero, Alejandro
Published in Journal of medicinal chemistry (22.07.2010)
Published in Journal of medicinal chemistry (22.07.2010)
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Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease
Maalej, Emna, Chabchoub, Fakher, Oset-Gasque, María Jesús, Esquivias-Pérez, Mario, González, María P., Monjas, Leticia, Pérez, Concepción, de los Ríos, Cristóbal, Rodríguez-Franco, María Isabel, Iriepa, Isabel, Moraleda, Ignacio, Chioua, Mourad, Romero, Alejandro, Marco-Contelles, José, Samadi, Abdelouahid
Published in European journal of medicinal chemistry (01.08.2012)
Published in European journal of medicinal chemistry (01.08.2012)
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Melatonin as Modulator for Sulfur and Nitrogen Mustard-Induced Inflammation, Oxidative Stress and DNA Damage: Molecular Therapeutics
Ramos, Eva, Gil-Martín, Emilio, De Los Ríos, Cristóbal, Egea, Javier, López-Muñoz, Francisco, Pita, René, Juberías, Antonio, Torrado, Juan J, Serrano, Dolores R, Reiter, Russel J, Romero, Alejandro
Published in Antioxidants (01.02.2023)
Published in Antioxidants (01.02.2023)
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Polyfunctionalized α-Phenyl-tert-butyl(benzyl)nitrones: Multifunctional Antioxidants for Stroke Treatment
Diez-Iriepa, Daniel, Knez, Damijan, Gobec, Stanislav, Iriepa, Isabel, de los Ríos, Cristóbal, Bravo, Isaac, López-Muñoz, Francisco, Marco-Contelles, José, Hadjipavlou-Litina, Dimitra
Published in Antioxidants (31.08.2022)
Published in Antioxidants (31.08.2022)
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Promising Molecular Targets in Pharmacological Therapy for Neuronal Damage in Brain Injury
de Los Ríos, Cristóbal, Viejo, Lucía, Carretero, Victoria Jiménez, Juárez, Natalia Hernández, Cruz-Martins, Natália, Hernández-Guijo, Jesús M
Published in Antioxidants (03.01.2023)
Published in Antioxidants (03.01.2023)
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Toxicology of Blister Agents: Is Melatonin a Potential Therapeutic Option?
Romero, Alejandro, Ramos, Eva, López-Muñoz, Francisco, De Los Ríos, Cristóbal, Egea, Javier, Gil-Martín, Emilio, Pita, René, Torrado, Juan J, Serrano, Dolores R, Juberias, Antonio
Published in Diseases (10.04.2021)
Published in Diseases (10.04.2021)
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Tacrines for Alzheimer's disease therapy. III. The PyridoTacrines
de los Ríos, Cristóbal, Marco-Contelles, José
Published in European journal of medicinal chemistry (15.03.2019)
Published in European journal of medicinal chemistry (15.03.2019)
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