Evaluation of blood-brain barrier transport and CNS drug metabolism in diseased and control brain after intravenous L-DOPA in a unilateral rat model of Parkinson's disease
Ravenstijn, Paulien Gm, Drenth, Henk-Jan, O'Neill, Michael J, Danhof, Meindert, de Lange, Elizabeth Cm
Published in Fluids and barriers of the CNS (08.02.2012)
Published in Fluids and barriers of the CNS (08.02.2012)
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Journal Article
Exploring Kp,uu,BBB values smaller than unity in remoxipride: A physiologically-based CNS model approach highlighting brain metabolism in drugs with passive blood-brain barrier transport
Zhang, Mengxu, Vuist, Ilona M., Rottschäfer, Vivi, de Lange, Elizabeth CM
Published in European journal of pharmaceutical sciences (01.12.2024)
Published in European journal of pharmaceutical sciences (01.12.2024)
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Journal Article
Corrigendum to “Does nonlinear blood-brain barrier transport matter for (lower) morphine dosing strategies?” [European Journal of Pharmaceutical Sciences 187 (2023) 106482]
Gülave, Berfin, Budda, Divakar, Saleh, Mohammed AA, van Hasselt, JG Coen, de Lange, Elizabeth CM
Published in European journal of pharmaceutical sciences (01.05.2024)
Published in European journal of pharmaceutical sciences (01.05.2024)
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Journal Article
Next-generation biomarker discovery in Alzheimer's disease using metabolomics - from animal to human studies
Hurtado, Marina Ollé, Kohler, Isabelle, de Lange, Elizabeth CM
Published in Bioanalysis (01.09.2018)
Published in Bioanalysis (01.09.2018)
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Journal Article
Mechanism-based pharmacokinetic-pharmacodynamic modeling: biophase distribution, receptor theory, and dynamical systems analysis
Danhof, Meindert, de Jongh, Joost, De Lange, Elizabeth C M, Della Pasqua, Oscar, Ploeger, Bart A, Voskuyl, Rob A
Published in Annual review of pharmacology and toxicology (01.01.2007)
Published in Annual review of pharmacology and toxicology (01.01.2007)
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Journal Article
T lymphocytes impair P-glycoprotein function during neuroinflammation
Kooij, Gijs, van Horssen, Jack, de Lange, Elizabeth C.M, Reijerkerk, Arie, van der Pol, Susanne M.A, van het Hof, Bert, Drexhage, Joost, Vennegoor, Anke, Killestein, Joep, Scheffer, George, Oerlemans, Ruud, Scheper, Rik, van der Valk, Paul, Dijkstra, Christine D, de Vries, Helga E
Published in Journal of autoimmunity (01.06.2010)
Published in Journal of autoimmunity (01.06.2010)
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Methodological issues in microdialysis sampling for pharmacokinetic studies
de Lange, Elizabeth C.M., de Boer, A.G., Breimer, Douwe D.
Published in Advanced drug delivery reviews (15.12.2000)
Published in Advanced drug delivery reviews (15.12.2000)
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Journal Article
Quantitative microdialysis using modified ultraslow microdialysis: Direct rapid and reliable determination of free brain concentrations with the MetaQuant technique
Cremers, Thomas I.F.H., de Vries, Martin G., Huinink, Kirsten D., Loon, Jan Paul van, Hart, Marieke v.d., Ebert, Bjarke, Westerink, Ben H.C., De Lange, Elizabeth C.M.
Published in Journal of neuroscience methods (15.04.2009)
Published in Journal of neuroscience methods (15.04.2009)
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Journal Article
The exploration of rotenone as a toxin for inducing Parkinson's disease in rats, for application in BBB transport and PK–PD experiments
Ravenstijn, Paulien G.M., Merlini, Mario, Hameetman, Marjolijn, Murray, Tracey K., Ward, Mark A., Lewis, Hywel, Ball, Gareth, Mottart, Cathy, de Ville de Goyet, Christine, Lemarchand, Thomas, van Belle, Kristel, O'Neill, Michael J., Danhof, Meindert, de Lange, Elizabeth C.M.
Published in Journal of pharmacological and toxicological methods (01.03.2008)
Published in Journal of pharmacological and toxicological methods (01.03.2008)
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Journal Article
Potential Mechanisms Underlying Resistance to Dementia in Non-Demented Individuals with Alzheimer’s Disease Neuropathology
Kok, Frédérique K., van Leerdam, Suzanne L., de Lange, Elizabeth C.M.
Published in Journal of Alzheimer's disease (01.01.2022)
Published in Journal of Alzheimer's disease (01.01.2022)
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Book Review
Journal Article
Online solid phase extraction with liquid chromatography–tandem mass spectrometry to analyze remoxipride in small plasma-, brain homogenate-, and brain microdialysate samples
Stevens, Jasper, van den Berg, Dirk-Jan, de Ridder, Sanne, Niederländer, Harm A.G., van der Graaf, Piet Hein, Danhof, Meindert, de Lange, Elizabeth C.M.
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.04.2010)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.04.2010)
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Journal Article
[11C]Flumazenil brain uptake is influenced by the blood-brain barrier efflux transporter P-glycoprotein
Froklage, Femke E, Syvänen, Stina, Hendrikse, N Harry, Huisman, Marc C, Molthoff, Carla FM, Tagawa, Yoshihiko, Reijneveld, Jaap C, Heimans, Jan J, Lammertsma, Adriaan A, Eriksson, Jonas, de Lange, Elizabeth CM, Voskuyl, Rob A
Published in EJNMMI research (28.03.2012)
Published in EJNMMI research (28.03.2012)
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Journal Article
LUF7244, an allosteric modulator/activator of Kv11.1 channels, counteracts dofetilide‐induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model
Qile, Muge, Beekman, Henriette D.M., Sprenkeler, David J., Houtman, Marien J.C., Ham, Willem B., Stary‐Weinzinger, Anna, Beyl, Stanislav, Hering, Steffen, Berg, Dirk‐Jan, Lange, Elizabeth C.M., Heitman, Laura H., IJzerman, Ad P., Vos, Marc A., Heyden, Marcel A.G.
Published in British journal of pharmacology (01.10.2019)
Published in British journal of pharmacology (01.10.2019)
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Journal Article
Utility of Animal Models to Understand Human Alzheimer's Disease, Using the Mastermind Research Approach to Avoid Unnecessary Further Sacrifices of Animals
Qin, Tian, Prins, Samantha, Groeneveld, Geert Jan, Van Westen, Gerard, de Vries, Helga E, Wong, Yin Cheong, Bischoff, Luc J M, de Lange, Elizabeth C M
Published in International journal of molecular sciences (30.04.2020)
Published in International journal of molecular sciences (30.04.2020)
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Journal Article