Mechanistic Study on the Use of the l‑Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets
Puris, Elena, Gynther, Mikko, de Lange, Elizabeth C.M, Auriola, Seppo, Hammarlund-Udenaes, Margareta, Huttunen, Kristiina M, Loryan, Irena
Published in Molecular pharmaceutics (01.07.2019)
Published in Molecular pharmaceutics (01.07.2019)
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Altered protein expression of membrane transporters in isolated cerebral microvessels and brain cortex of a rat Alzheimer's disease model
Puris, Elena, Auriola, Seppo, Petralla, Sabrina, Hartman, Robin, Gynther, Mikko, de Lange, Elizabeth C.M., Fricker, Gert
Published in Neurobiology of disease (01.07.2022)
Published in Neurobiology of disease (01.07.2022)
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High-performance liquid chromatography of nalbuphine, butorphanol and morphine in blood and brain microdialysate samples: Application to pharmacokinetic/pharmacodynamic studies in rats
Groenendaal, Dorien, Blom-Roosemalen, Margret C.M., Danhof, Meindert, Lange, Elizabeth C.M. de
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (05.08.2005)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (05.08.2005)
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Utility of Animal Models to Understand Human Alzheimer's Disease, Using the Mastermind Research Approach to Avoid Unnecessary Further Sacrifices of Animals
Qin, Tian, Prins, Samantha, Groeneveld, Geert Jan, Van Westen, Gerard, de Vries, Helga E, Wong, Yin Cheong, Bischoff, Luc J M, de Lange, Elizabeth C M
Published in International journal of molecular sciences (30.04.2020)
Published in International journal of molecular sciences (30.04.2020)
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Effects of daily L-dopa administration on learning and brain structure in older adults undergoing cognitive training: a randomised clinical trial
Lebedev, Alexander V, Nilsson, Jonna, Lindström, Joanna, Fredborg, William, Akenine, Ulrika, Hillilä, Carolina, Andersen, Pia, Spulber, Gabriela, de Lange, Elizabeth C M, van den Berg, Dirk-Jan, Kivipelto, Miia, Lövdén, Martin
Published in Scientific reports (23.03.2020)
Published in Scientific reports (23.03.2020)
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Prediction of methotrexate CNS distribution in different species – Influence of disease conditions
Westerhout, Joost, van den Berg, Dirk-Jan, Hartman, Robin, Danhof, Meindert, de Lange, Elizabeth C.M.
Published in European journal of pharmaceutical sciences (16.06.2014)
Published in European journal of pharmaceutical sciences (16.06.2014)
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T lymphocytes impair P-glycoprotein function during neuroinflammation
Kooij, Gijs, van Horssen, Jack, de Lange, Elizabeth C.M, Reijerkerk, Arie, van der Pol, Susanne M.A, van het Hof, Bert, Drexhage, Joost, Vennegoor, Anke, Killestein, Joep, Scheffer, George, Oerlemans, Ruud, Scheper, Rik, van der Valk, Paul, Dijkstra, Christine D, de Vries, Helga E
Published in Journal of autoimmunity (01.06.2010)
Published in Journal of autoimmunity (01.06.2010)
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Methodological issues in microdialysis sampling for pharmacokinetic studies
de Lange, Elizabeth C.M., de Boer, A.G., Breimer, Douwe D.
Published in Advanced drug delivery reviews (15.12.2000)
Published in Advanced drug delivery reviews (15.12.2000)
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Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier
Wijnholds, J, deLange, E C, Scheffer, G L, van den Berg, D J, Mol, C A, van der Valk, M, Schinkel, A H, Scheper, R J, Breimer, D D, Borst, P
Published in The Journal of clinical investigation (01.02.2000)
Published in The Journal of clinical investigation (01.02.2000)
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Blood‐Based Biomarkers of Quinpirole Pharmacology: Cluster‐Based PK/PD and Metabolomics to Unravel the Underlying Dynamics in Rat Plasma and Brain
Brink, Willem J., Hartman, Robin, Berg, Dirk‐Jan, Flik, Gunnar, Gonzalez‐Amoros, Belén, Koopman, Nanda, Elassais‐Schaap, Jeroen, Graaf, Piet Hein, Hankemeier, Thomas, Lange, Elizabeth C.M.
Published in CPT: pharmacometrics and systems pharmacology (01.02.2019)
Published in CPT: pharmacometrics and systems pharmacology (01.02.2019)
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Evaluation of blood-brain barrier transport and CNS drug metabolism in diseased and control brain after intravenous L-DOPA in a unilateral rat model of Parkinson's disease
Ravenstijn, Paulien Gm, Drenth, Henk-Jan, O'Neill, Michael J, Danhof, Meindert, de Lange, Elizabeth Cm
Published in Fluids and barriers of the CNS (08.02.2012)
Published in Fluids and barriers of the CNS (08.02.2012)
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The exploration of rotenone as a toxin for inducing Parkinson's disease in rats, for application in BBB transport and PK–PD experiments
Ravenstijn, Paulien G.M., Merlini, Mario, Hameetman, Marjolijn, Murray, Tracey K., Ward, Mark A., Lewis, Hywel, Ball, Gareth, Mottart, Cathy, de Ville de Goyet, Christine, Lemarchand, Thomas, van Belle, Kristel, O'Neill, Michael J., Danhof, Meindert, de Lange, Elizabeth C.M.
Published in Journal of pharmacological and toxicological methods (01.03.2008)
Published in Journal of pharmacological and toxicological methods (01.03.2008)
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Summary data of potency and parameter information from semi-mechanistic PKPD modeling of prolactin release following administration of the dopamine D2 receptor antagonists risperidone, paliperidone and remoxipride in rats
Taneja, Amit, Vermeulen, An, Huntjens, Dymphy R.H., Danhof, Meindert, De Lange, Elizabeth C.M., Proost, Johannes H.
Published in Data in brief (01.09.2016)
Published in Data in brief (01.09.2016)
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Targeted brain delivery of methotrexate by glutathione PEGylated liposomes: How can the formulation make a difference?
Hu, Yang, Gaillard, Pieter J., de Lange, Elizabeth C.M., Hammarlund-Udenaes, Margareta
Published in European journal of pharmaceutics and biopharmaceutics (01.06.2019)
Published in European journal of pharmaceutics and biopharmaceutics (01.06.2019)
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