In situ CRISPR‐Cas9 base editing for the development of genetically engineered mouse models of breast cancer
Annunziato, Stefano, Lutz, Catrin, Henneman, Linda, Bhin, Jinhyuk, Wong, Kim, Siteur, Bjørn, van Gerwen, Bas, de Korte‐Grimmerink, Renske, Zafra, Maria Paz, Schatoff, Emma M, Drenth, Anne Paulien, van der Burg, Eline, Eijkman, Timo, Mukherjee, Siddhartha, Boroviak, Katharina, Wessels, Lodewyk FA, van de Ven, Marieke, Huijbers, Ivo J, Adams, David J, Dow, Lukas E, Jonkers, Jos
Published in The EMBO journal (02.03.2020)
Published in The EMBO journal (02.03.2020)
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Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer
Henneman, Linda, van Miltenburg, Martine H., Michalak, Ewa M., Braumuller, Tanya M., Jaspers, Janneke E., Drenth, Anne Paulien, de Korte-Grimmerink, Renske, Gogola, Ewa, Szuhai, Karoly, Schlicker, Andreas, Ali, Rahmen Bin, Pritchard, Colin, Huijbers, Ivo J., Berns, Anton, Rottenberg, Sven, Jonkers, Jos
Published in Proceedings of the National Academy of Sciences - PNAS (07.07.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (07.07.2015)
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Division of labor within the DNA damage tolerance system reveals non-epistatic and clinically actionable targets for precision cancer medicine
Spanjaard, Aldo, Shah, Ronak, de Groot, Daniël, Buoninfante, Olimpia Alessandra, Morris, Ben, Lieftink, Cor, Pritchard, Colin, Zürcher, Lisa M, Ormel, Shirley, Catsman, Joyce J I, de Korte-Grimmerink, Renske, Siteur, Bjørn, Proost, Natalie, Boadum, Terry, van de Ven, Marieke, Song, Ji-Ying, Kreft, Maaike, van den Berk, Paul C M, Beijersbergen, Roderick L, Jacobs, Heinz
Published in Nucleic acids research (22.07.2022)
Published in Nucleic acids research (22.07.2022)
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Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining
Francica, Paola, Mutlu, Merve, Blomen, Vincent A., Oliveira, Catarina, Nowicka, Zuzanna, Trenner, Anika, Gerhards, Nora M., Bouwman, Peter, Stickel, Elmer, Hekkelman, Maarten L., Lingg, Lea, Klebic, Ismar, van de Ven, Marieke, de Korte-Grimmerink, Renske, Howald, Denise, Jonkers, Jos, Sartori, Alessandro A., Fendler, Wojciech, Chapman, J. Ross, Brummelkamp, Thijn, Rottenberg, Sven
Published in Cell reports (Cambridge) (25.08.2020)
Published in Cell reports (Cambridge) (25.08.2020)
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Combined inhibition of EZH2 and ATM is synthetic lethal in BRCA1-deficient breast cancer
Ratz, Leonie, Brambillasca, Chiara, Bartke, Leandra, Huetzen, Maxim A, Goergens, Jonas, Leidecker, Orsolya, Jachimowicz, Ron D, van de Ven, Marieke, Proost, Natalie, Siteur, Bjarn, de Korte-Grimmerink, Renske, Bouwman, Peter, Pulver, Emilia M, de Bruijn, Roebi, Isensee, Jörg, Hucho, Tim, Pandey, Gaurav, van Lohuizen, Maarten, Mallmann, Peter, Reinhardt, Hans Christian, Jonkers, Jos, Puppe, Julian
Published in Breast cancer research : BCR (17.06.2022)
Published in Breast cancer research : BCR (17.06.2022)
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Radiosensitivity Is an Acquired Vulnerability of PARPi-Resistant BRCA1-Deficient Tumors
Barazas, Marco, Gasparini, Alessia, Huang, Yike, Küçükosmanoğlu, Asli, Annunziato, Stefano, Bouwman, Peter, Sol, Wendy, Kersbergen, Ariena, Proost, Natalie, de Korte-Grimmerink, Renske, van de Ven, Marieke, Jonkers, Jos, Borst, Gerben R, Rottenberg, Sven
Published in Cancer research (Chicago, Ill.) (01.02.2019)
Published in Cancer research (Chicago, Ill.) (01.02.2019)
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Truncated FGFR2 is a clinically actionable oncogene in multiple cancers
Zingg, Daniel, Bhin, Jinhyuk, Yemelyanenko, Julia, Kas, Sjors M., Rolfs, Frank, Lutz, Catrin, Lee, Jessica K., Klarenbeek, Sjoerd, Silverman, Ian M., Annunziato, Stefano, Chan, Chang S., Piersma, Sander R., Eijkman, Timo, Badoux, Madelon, Gogola, Ewa, Siteur, Bjørn, Sprengers, Justin, de Klein, Bim, de Goeij-de Haas, Richard R., Riedlinger, Gregory M., Ke, Hua, Madison, Russell, Drenth, Anne Paulien, van der Burg, Eline, Schut, Eva, Henneman, Linda, van Miltenburg, Martine H., Proost, Natalie, Zhen, Huiling, Wientjens, Ellen, de Bruijn, Roebi, de Ruiter, Julian R., Boon, Ute, de Korte-Grimmerink, Renske, van Gerwen, Bastiaan, Féliz, Luis, Abou-Alfa, Ghassan K., Ross, Jeffrey S., van de Ven, Marieke, Rottenberg, Sven, Cuppen, Edwin, Chessex, Anne Vaslin, Ali, Siraj M., Burn, Timothy C., Jimenez, Connie R., Ganesan, Shridar, Wessels, Lodewyk F. A., Jonkers, Jos
Published in Nature (London) (18.08.2022)
Published in Nature (London) (18.08.2022)
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Transcriptomics and Transposon Mutagenesis Identify Multiple Mechanisms of Resistance to the FGFR Inhibitor AZD4547
Kas, Sjors M, de Ruiter, Julian R, Schipper, Koen, Schut, Eva, Bombardelli, Lorenzo, Wientjens, Ellen, Drenth, Anne Paulien, de Korte-Grimmerink, Renske, Mahakena, Sunny, Phillips, Christopher, Smith, Paul D, Klarenbeek, Sjoerd, van de Wetering, Koen, Berns, Anton, Wessels, Lodewyk F A, Jonkers, Jos
Published in Cancer research (Chicago, Ill.) (01.10.2018)
Published in Cancer research (Chicago, Ill.) (01.10.2018)
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Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis
Wellenstein, Max D., Coffelt, Seth B., Duits, Danique E. M., van Miltenburg, Martine H., Slagter, Maarten, de Rink, Iris, Henneman, Linda, Kas, Sjors M., Prekovic, Stefan, Hau, Cheei-Sing, Vrijland, Kim, Drenth, Anne Paulien, de Korte-Grimmerink, Renske, Schut, Eva, van der Heijden, Ingrid, Zwart, Wilbert, Wessels, Lodewyk F. A., Schumacher, Ton N., Jonkers, Jos, de Visser, Karin E.
Published in Nature (London) (01.08.2019)
Published in Nature (London) (01.08.2019)
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A BRCA1 Coiled-Coil Domain Variant Disrupting PALB2 Interaction Promotes the Development of Mammary Tumors and Confers a Targetable Defect in Homologous Recombination Repair
Pulver, Emilia M, Mukherjee, Chirantani, van de Kamp, Gerarda, Roobol, Stefan J, Rother, Magdalena B, van der Gulden, Hanneke, de Bruijn, Roebi, Lattanzio, Maria Valeria, van der Burg, Eline, Drenth, Anne Paulien, Verkaik, Nicole S, Hahn, Kerstin, Klarenbeek, Sjoerd, de Korte-Grimmerink, Renske, van de Ven, Marieke, Pritchard, Colin E J, Huijbers, Ivo J, Xia, Bing, van Gent, Dik C, Essers, Jeroen, van Attikum, Haico, Ray Chaudhuri, Arnab, Bouwman, Peter, Jonkers, Jos
Published in Cancer research (Chicago, Ill.) (15.12.2021)
Published in Cancer research (Chicago, Ill.) (15.12.2021)
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Publisher Correction: Truncated FGFR2 is a clinically actionable oncogene in multiple cancers
Zingg, Daniel, Bhin, Jinhyuk, Yemelyanenko, Julia, Kas, Sjors M., Rolfs, Frank, Lutz, Catrin, Lee, Jessica K., Klarenbeek, Sjoerd, Silverman, Ian M., Annunziato, Stefano, Chan, Chang S., Piersma, Sander R., Eijkman, Timo, Badoux, Madelon, Gogola, Ewa, Siteur, Bjørn, Sprengers, Justin, de Klein, Bim, de Goeij-de Haas, Richard R., Riedlinger, Gregory M., Ke, Hua, Madison, Russell, Drenth, Anne Paulien, van der Burg, Eline, Schut, Eva, Henneman, Linda, van Miltenburg, Martine H., Proost, Natalie, Zhen, Huiling, Wientjens, Ellen, de Bruijn, Roebi, de Ruiter, Julian R., Boon, Ute, de Korte-Grimmerink, Renske, van Gerwen, Bastiaan, Féliz, Luis, Abou-Alfa, Ghassan K., Ross, Jeffrey S., van de Ven, Marieke, Rottenberg, Sven, Cuppen, Edwin, Chessex, Anne Vaslin, Ali, Siraj M., Burn, Timothy C., Jimenez, Connie R., Ganesan, Shridar, Wessels, Lodewyk F. A., Jonkers, Jos
Published in Nature (London) (29.09.2022)
Published in Nature (London) (29.09.2022)
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Loss of the volume-regulated anion channel components LRRC8A and LRRC8D limits platinum drug efficacy
Widmer, Carmen A, Klebic, Ismar, Domanitskaya, Natalya, Decollogny, Morgane, Howald, Denise, Siffert, Myriam, Essers, Paul, Nowicka, Zuzanna, Stokar-Regenscheit, Nadine, van de Ven, Marieke, de Korte-Grimmerink, Renske, Galván, José A, Pritchard, Colin E J, Huijbers, Ivo J, Fendler, Wojciech, Vens, Conchita, Rottenberg, Sven
Published in Cancer research communications (26.10.2022)
Published in Cancer research communications (26.10.2022)
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Cancer modeling in colorectal organoids reveals intrinsic differences between oncogenic RAS and BRAF variants
Post, Jasmin B, Hami, Nizar, Lohuis, Jeroen, Van De Ven, Marieke, Renske De Korte-Grimmerink, Stangl, Christina S, Stelloo, Ellen, Verlaan, Ingrid, Jacco Van Rheenen, Snippert, Hugo Jg
Published in bioRxiv (29.11.2019)
Published in bioRxiv (29.11.2019)
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