Long-Term Efficacy, Safety, and Pharmacokinetics of Drisapersen in Duchenne Muscular Dystrophy: Results from an Open-Label Extension Study
Goemans, Nathalie M, Tulinius, Már, van den Hauwe, Marleen, Kroksmark, Anna-Karin, Buyse, Gunnar, Wilson, Rosamund J, van Deutekom, Judith C, de Kimpe, Sjef J, Lourbakos, Afrodite, Campion, Giles
Published in PloS one (02.09.2016)
Published in PloS one (02.09.2016)
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Safety and efficacy of drisapersen for the treatment of Duchenne muscular dystrophy (DEMAND II): an exploratory, randomised, placebo-controlled phase 2 study
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Published in Lancet neurology (01.10.2014)
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A sensitive, reproducible and objective immunofluorescence analysis method of dystrophin in individual fibers in samples from patients with duchenne muscular dystrophy
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Published in PloS one (22.09.2014)
Published in PloS one (22.09.2014)
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Systemic Administration of PRO051 in Duchenne's Muscular Dystrophy
Goemans, Nathalie M, Tulinius, Mar, van den Akker, Johanna T, Burm, Brigitte E, Ekhart, Peter F, Heuvelmans, Niki, Holling, Tjadine, Janson, Anneke A, Platenburg, Gerard J, Sipkens, Jessica A, Sitsen, J.M. Ad, Aartsma-Rus, Annemieke, van Ommen, Gert-Jan B, Buyse, Gunnar, Darin, Niklas, Verschuuren, Jan J, Campion, Giles V, de Kimpe, Sjef J, van Deutekom, Judith C
Published in The New England journal of medicine (21.04.2011)
Published in The New England journal of medicine (21.04.2011)
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Toll-like receptor-4 mediates cigarette smoke-induced cytokine production by human macrophages
Karimi, Khalil, Sarir, Hadi, Mortaz, Esmaeil, Smit, Joost J, Hosseini, Hossein, De Kimpe, Sjef J, Nijkamp, Frans P, Folkerts, Gert
Published in Respiratory research (19.04.2006)
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Species-specific inflammatory responses as a primary component for the development of glomerular lesions in mice and monkeys following chronic administration of a second-generation antisense oligonucleotide
Frazier, Kendall S, Sobry, Cécile, Derr, Victoria, Adams, Mike J, Besten, Cathaline Den, De Kimpe, Sjef, Francis, Ian, Gales, Tracy L, Haworth, Richard, Maguire, Shaun R, Mirabile, Rosanna C, Mullins, David, Palate, Bernard, Doorten, Yolanda Ponstein-Simarro, Ridings, James E, Scicchitano, Marshall S, Silvano, Jérémy, Woodfine, Jennie
Published in Toxicologic pathology (01.07.2014)
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Triplet-repeat oligonucleotide-mediated reversal of RNA toxicity in myotonic dystrophy
Mulders, Susan A.M, van den Broek, Walther J.A.A, Wheeler, Thurman M, Croes, Huib J.E, van Kuik-Romeijn, Petra, de Kimpe, Sjef J, Furling, Denis, Platenburg, Gerard J, Gourdon, Geneviève, Thornton, Charles A, Wieringa, Bé, Wansink, Derick G
Published in Proceedings of the National Academy of Sciences - PNAS (18.08.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (18.08.2009)
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In vivo comparison of 2′-O-methyl phosphorothioate and morpholino antisense oligonucleotides for Duchenne muscular dystrophy exon skipping
Heemskerk, Hans A., de Winter, Christa L., de Kimpe, Sjef J., van Kuik-Romeijn, Petra, Heuvelmans, Niki, Platenburg, Gerard J., van Ommen, Gert-Jan B., van Deutekom, Judith C. T., Aartsma-Rus, Annemieke
Published in The journal of gene medicine (01.03.2009)
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Long-term Exon Skipping Studies With 2′-O-Methyl Phosphorothioate Antisense Oligonucleotides in Dystrophic Mouse Models
Tanganyika-de Winter, Christa L, Heemskerk, Hans, Karnaoukh, Tatyana G, van Putten, Maaike, de Kimpe, Sjef J, van Deutekom, Judith, Aartsma-Rus, Annemieke
Published in Molecular therapy. Nucleic acids (01.09.2012)
Published in Molecular therapy. Nucleic acids (01.09.2012)
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Local Dystrophin Restoration with Antisense Oligonucleotide PRO051
van Deutekom, Judith C, Janson, Anneke A, Ginjaar, Ieke B, Frankhuizen, Wendy S, Aartsma-Rus, Annemieke, Bremmer-Bout, Mattie, den Dunnen, Johan T, Koop, Klaas, van der Kooi, Anneke J, Goemans, Nathalie M, de Kimpe, Sjef J, Ekhart, Peter F, Venneker, Edna H, Platenburg, Gerard J, Verschuuren, Jan J, van Ommen, Gert-Jan B
Published in The New England journal of medicine (27.12.2007)
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The Dynamics of Compound, Transcript, and Protein Effects After Treatment With 2OMePS Antisense Oligonucleotides in mdx Mice
Verhaart, Ingrid E C, van Vliet-van den Dool, Laura, Sipkens, Jessica A, de Kimpe, Sjef J, Kolfschoten, Ingrid G M, van Deutekom, Judith C T, Liefaard, Lia, Ridings, Jim E, Hood, Steve R, Aartsma-Rus, Annemieke
Published in Molecular therapy. Nucleic acids (01.02.2014)
Published in Molecular therapy. Nucleic acids (01.02.2014)
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M6229 Protects against Extracellular-Histone-Induced Liver Injury, Kidney Dysfunction, and Mortality in a Rat Model of Acute Hyperinflammation
Reutelingsperger, Chris P M, Gijbels, Marion J, Spronk, Henri, Van Oerle, Rene, Schrijver, Roy, Ekhart, Peter, de Kimpe, Sjef, Nicolaes, Gerry A F
Published in International journal of molecular sciences (01.02.2024)
Published in International journal of molecular sciences (01.02.2024)
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The Pharmacokinetics of 2'- O -Methyl Phosphorothioate Antisense Oligonucleotides: Experiences from Developing Exon Skipping Therapies for Duchenne Muscular Dystrophy
Bosgra, Sieto, Sipkens, Jessica, de Kimpe, Sjef, den Besten, Cathaline, Datson, Nicole, van Deutekom, Judith
Published in Nucleic acid therapeutics (01.12.2019)
Published in Nucleic acid therapeutics (01.12.2019)
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Preclinical PK and PD Studies on 2′-O-Methyl-phosphorothioate RNA Antisense Oligonucleotides in the mdx Mouse Model
Heemskerk, Hans, de Winter, Christa, van Kuik, Petra, Heuvelmans, Niki, Sabatelli, Patrizia, Rimessi, Paola, Braghetta, Paola, van Ommen, Gert-Jan B, de Kimpe, Sjef, Ferlini, Alessandra, Aartsma-Rus, Annemieke, van Deutekom, Judith CT
Published in Molecular therapy (01.06.2010)
Published in Molecular therapy (01.06.2010)
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Bis(maltolato)oxovanadium(IV) Induces Angiogenesis via Phosphorylation of VEGFR2
Parma, Laura, Peters, Hendrika A B, Johansson, Maria E, Gutiérrez, Saray, Meijerink, Henk, de Kimpe, Sjef, de Vries, Margreet R, Quax, Paul H A
Published in International journal of molecular sciences (30.06.2020)
Published in International journal of molecular sciences (30.06.2020)
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Dose-Dependent Pharmacokinetic Profiles of 2′-O-Methyl Phosphorothioate Antisense Oligonucleotidesin mdx Mice
Verhaart, Ingrid E.C., Tanganyika-de Winter, Christa L., Karnaoukh, Tatyana G., Kolfschoten, Ingrid G.M., de Kimpe, Sjef J., van Deutekom, Judith C.T., Aartsma-Rus, Annemieke
Published in Nucleic acid therapeutics (01.06.2013)
Published in Nucleic acid therapeutics (01.06.2013)
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Mechanism of gram-positive shock: identification of peptidoglycan and lipoteichoic acid moieties essential in the induction of nitric oxide synthase, shock, and multiple organ failure
Kengatharan, K M, De Kimpe, S, Robson, C, Foster, S J, Thiemermann, C
Published in The Journal of experimental medicine (20.07.1998)
Published in The Journal of experimental medicine (20.07.1998)
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Preclinical Studies on Intestinal Administration of Antisense Oligonucleotides as a Model for Oral Delivery for Treatment of Duchenne Muscular Dystrophy
van Putten, Maaike, Young, Courtney, van den Berg, Sjoerd, Pronk, Amanda, Hulsker, Margriet, Karnaoukh, Tatyana G, Vermue, Rick, van Dijk, Ko Willems, de Kimpe, Sjef, Aartsma-Rus, Annemieke
Published in Molecular therapy. Nucleic acids (2014)
Published in Molecular therapy. Nucleic acids (2014)
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Inhibition of IL-1 Signaling by Antisense Oligonucleotide-mediated Exon Skipping of IL-1 Receptor Accessory Protein (IL-1RAcP)
Yılmaz-Eliş, A Seda, Aartsma-Rus, Annemieke, 't Hoen, Peter AC, Safdar, Huma, Breukel, Cor, van Vlijmen, Bart JM, van Deutekom, Judith, de Kimpe, Sjef, van Ommen, Gert-Jan, Verbeek, J Sjef
Published in Molecular therapy. Nucleic acids (01.01.2013)
Published in Molecular therapy. Nucleic acids (01.01.2013)
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Vitamin E alleviates renal injury, but not hypertension, during chronic nitric oxide synthase inhibition in rats
ATTIA, Diana M, VERHAGEN, A. Marjan G, STROES, Erik S. G, VAN FAASSEN, Ernst E, GRÖNE, Hermann-Josef, DE KIMPE, Sjef J, KOOMANS, Hein A, BRAAM, Branko, JOLES, Jaap A
Published in Journal of the American Society of Nephrology (01.12.2001)
Published in Journal of the American Society of Nephrology (01.12.2001)
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