Discovery of an Oral, Rule of 5 Compliant, Interleukin 17A Protein–Protein Interaction Modulator for the Potential Treatment of Psoriasis and Other Inflammatory Diseases
Andrews, Mark D., Dack, Kevin N., de Groot, Marcel J., Lambert, Maja, Sennbro, Carl J., Larsen, Mogens, Stahlhut, Martin
Published in Journal of medicinal chemistry (14.07.2022)
Published in Journal of medicinal chemistry (14.07.2022)
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Quantum Mechanics/Molecular Mechanics Modeling of Regioselectivity of Drug Metabolism in Cytochrome P450 2C9
Lonsdale, Richard, Houghton, Kerensa T, Żurek, Jolanta, Bathelt, Christine M, Foloppe, Nicolas, de Groot, Marcel J, Harvey, Jeremy N, Mulholland, Adrian J
Published in Journal of the American Chemical Society (29.05.2013)
Published in Journal of the American Chemical Society (29.05.2013)
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Structural Determinants of HERG Channel Block by Clofilium and Ibutilide
Matthew Perry, Marcel J. de Groot, Ray Helliwell, Derek Leishman, Martin Tristani-Firouzi, Michael C. Sanguinetti, John Mitcheson
Published in Molecular pharmacology (01.08.2004)
Published in Molecular pharmacology (01.08.2004)
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In silico methods for predicting ligand binding determinants of cytochromes P450
de Groot, Marcel J, Kirton, Stewart B, Sutcliffe, Michael J
Published in Current topics in medicinal chemistry (01.01.2004)
Published in Current topics in medicinal chemistry (01.01.2004)
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Drug Binding Interactions in the Inner Cavity of hERG Channels: Molecular Insights from Structure-Activity Relationships of Clofilium and Ibutilide Analogs
Perry, Matthew, Stansfeld, Phillip J, Leaney, Joanne, Wood, Claire, de Groot, Marcel J, Leishman, Derek, Sutcliffe, Michael J, Mitcheson, John S
Published in Molecular pharmacology (01.02.2006)
Published in Molecular pharmacology (01.02.2006)
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Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels
McCormack, Ken, Santos, Sonia, Chapman, Mark L, Krafte, Douglas S, Marron, Brian E, West, Christopher W, Krambis, Michael J, Antonio, Brett M, Zellmer, Shannon G, Printzenhoff, David, Padilla, Karen M, Lin, Zhixin, Wagoner, P Kay, Swain, Nigel A, Stupple, Paul A, de Groot, Marcel, Butt, Richard P, Castle, Neil A
Published in Proceedings of the National Academy of Sciences - PNAS (16.07.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (16.07.2013)
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Discovery of Clinical Candidate 4‑[2-(5-Amino‑1H‑pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro‑N‑1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7
Swain, Nigel. A, Batchelor, Dave, Beaudoin, Serge, Bechle, Bruce M, Bradley, Paul A, Brown, Alan D, Brown, Bruce, Butcher, Ken J, Butt, Richard P, Chapman, Mark L, Denton, Stephen, Ellis, David, Galan, Sebastien R. G, Gaulier, Steven M, Greener, Ben S, de Groot, Marcel J, Glossop, Mel S, Gurrell, Ian K, Hannam, Jo, Johnson, Matthew S, Lin, Zhixin, Markworth, Christopher J, Marron, Brian E, Millan, David S, Nakagawa, Shoko, Pike, Andy, Printzenhoff, David, Rawson, David J, Ransley, Sarah J, Reister, Steven M, Sasaki, Kosuke, Storer, R. Ian, Stupple, Paul A, West, Christopher W
Published in Journal of medicinal chemistry (24.08.2017)
Published in Journal of medicinal chemistry (24.08.2017)
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Genetic Basis for Differential Activities of Fluconazole and Voriconazole against Candida krusei
FUKUOKA, Takashi, JOHNSTON, Douglas A, WINSLOW, Carol A, DE GROOT, Marcel J, BURT, Catherine, HITCHCOCK, Christopher A, FILLER, Scott G
Published in Antimicrobial Agents and Chemotherapy (01.04.2003)
Published in Antimicrobial Agents and Chemotherapy (01.04.2003)
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Transformation of Aspergillus awamori by Agrobacterium tumefaciens-mediated homologous recombination
Gouka, R.J, Gerk, C, Hooykaas, P.J.J, Bundock, P, Musters, W, Verrips, C.T, Groot, M.J.A. de
Published in Nature biotechnology (01.06.1999)
Published in Nature biotechnology (01.06.1999)
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Fluorescently Labeled Analogues of Dofetilide as High-Affinity Fluorescence Polarization Ligands for the Human Ether-a-go-go-Related Gene (hERG) Channel
Singleton, David H, Boyd, Helen, Steidl-Nichols, Jill V, Deacon, Matt, de Groot, Marcel J, Price, David, Nettleton, David O, Wallace, Nora K, Troutman, Matthew D, Williams, Christine, Boyd, James G
Published in Journal of medicinal chemistry (28.06.2007)
Published in Journal of medicinal chemistry (28.06.2007)
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alpha-atrial natriuretic peptide, cyclic guanosine monophosphate, and endothelin in plasma as markers of myocardial depression in human septic shock
Hartemink, K J, Groeneveld, A B, de Groot, M C, Strack van Schijndel, R J, van Kamp, G, Thijs, L G
Published in Critical care medicine (01.01.2001)
Published in Critical care medicine (01.01.2001)
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Complement Activation in Patients with Sepsis Is in Part Mediated by C-Reactive Protein
Wolbink, Gert-Jan, Bossink, Ailko W. J., Groeneveld, A. B. Johan, Groot, Marcel C. M. de, Thijs, Lambertus G., Hack, C. Erik
Published in The Journal of infectious diseases (01.01.1998)
Published in The Journal of infectious diseases (01.01.1998)
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Agrobacterium tumefaciens-mediated transformation of filamentous fungi
Groot, M.J.A. de, Bundock, P, Hooykaas, P.J.J, Beijersbergen, A.G.M
Published in Nature biotechnology (01.09.1998)
Published in Nature biotechnology (01.09.1998)
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A Novel Approach to Predicting P450 Mediated Drug Metabolism. CYP2D6 Catalyzed N-Dealkylation Reactions and Qualitative Metabolite Predictions Using a Combined Protein and Pharmacophore Model for CYP2D6
de Groot, Marcel J, Ackland, Mark J, Horne, Valerie A, Alex, Alexander A, Jones, Barry C
Published in Journal of medicinal chemistry (07.10.1999)
Published in Journal of medicinal chemistry (07.10.1999)
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