Search Results - "de Graaf, Inge A. M" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Adjusting the DNA Interaction and Anticancer Activity of Pt(II) N‑Heterocyclic Carbene Complexes by Steric Shielding of the Trans Leaving Group

Adjusting the DNA Interaction and Anticancer Activity of Pt(II) N‑Heterocyclic Carbene Complexes by Steric Shielding of the Trans Leaving Group

by Muenzner, Julienne K, Rehm, Tobias, Biersack, Bernhard, Casini, Angela, de Graaf, Inge A. M, Worawutputtapong, Pawida, Noor, Awal, Kempe, Rhett, Brabec, Viktor, Kasparkova, Jana, Schobert, Rainer
Published in Journal of medicinal chemistry (13.08.2015)

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Anticancer Gold N‐Heterocyclic Carbene Complexes: A Comparative in vitro and ex vivo Study

Anticancer Gold N‐Heterocyclic Carbene Complexes: A Comparative in vitro and ex vivo Study

by Estrada‐Ortiz, Natalia, Guarra, Federica, de Graaf, Inge A. M., Marchetti, Lorella, de Jager, Marina H., Groothuis, Geny M. M., Gabbiani, Chiara, Casini, Angela
Published in ChemMedChem (07.09.2017)

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Unraveling Hematotoxicity of α-Amanitin in Cultured Hematopoietic Cells

Unraveling Hematotoxicity of α-Amanitin in Cultured Hematopoietic Cells

by Hof, Willemien F J, Visser, Miranda, de Jong, Joyce J, Rajasekar, Marian N, Schuringa, Jan Jacob, de Graaf, Inge A M, Touw, Daan J, Dekkers, Bart G J
Published in Toxins (01.01.2024)

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Induction of Metabolism and Transport in Human Intestine: Validation of Precision-Cut Slices as a Tool to Study Induction of Drug Metabolism in Human Intestine in Vitro

Induction of Metabolism and Transport in Human Intestine: Validation of Precision-Cut Slices as a Tool to Study Induction of Drug Metabolism in Human Intestine in Vitro

by VAN DE KERKHOF, Esther G, DE GRAAF, Inge A. M, UNGELL, Anna-Lena B, GROOTHUIS, Geny M. M
Published in Drug metabolism and disposition (01.03.2008)

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On the toxicity and transport mechanisms of cisplatin in kidney tissues in comparison to a gold-based cytotoxic agent

On the toxicity and transport mechanisms of cisplatin in kidney tissues in comparison to a gold-based cytotoxic agent

by Spreckelmeyer, Sarah, Estrada-Ortiz, Natalia, Prins, Gerian G H, van der Zee, Margot, Gammelgaard, Bente, Stürup, Stefan, de Graaf, Inge A M, Groothuis, Geny M M, Casini, Angela
Published in Metallomics (01.12.2017)

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On-line HPLC Analysis System for Metabolism and Inhibition Studies in Precision-Cut Liver Slices

On-line HPLC Analysis System for Metabolism and Inhibition Studies in Precision-Cut Liver Slices

by van Midwoud, Paul M, Janssen, Joost, Merema, Marjolijn T, de Graaf, Inge A. M, Groothuis, Geny M. M, Verpoorte, Elisabeth
Published in Analytical chemistry (Washington) (01.01.2011)

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Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies

Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies

by de Graaf, Inge A M, Olinga, Peter, de Jager, Marina H, Merema, Marjolijn T, de Kanter, Ruben, van de Kerkhof, Esther G, Groothuis, Geny M M
Published in Nature protocols (01.09.2010)

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Improved Synthesis of N‑Benzylaminoferrocene-Based Prodrugs and Evaluation of Their Toxicity and Antileukemic Activity

Improved Synthesis of N‑Benzylaminoferrocene-Based Prodrugs and Evaluation of Their Toxicity and Antileukemic Activity

by Daum, Steffen, Chekhun, Vasiliy F, Todor, Igor N, Lukianova, Natalia Yu, Shvets, Yulia V, Sellner, Leopold, Putzker, Kerstin, Lewis, Joe, Zenz, Thorsten, de Graaf, Inge A. M, Groothuis, Geny M. M, Casini, Angela, Zozulia, Oleksii, Hampel, Frank, Mokhir, Andriy
Published in Journal of medicinal chemistry (26.02.2015)

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Glutathione-responsive cyclodextrin-nanosponges as drug delivery systems for doxorubicin: Evaluation of toxicity and transport mechanisms in the liver

Glutathione-responsive cyclodextrin-nanosponges as drug delivery systems for doxorubicin: Evaluation of toxicity and transport mechanisms in the liver

by Daga, Martina, de Graaf, Inge A.M., Argenziano, Monica, Barranco, Ana Sofia Martinez, Loeck, Maximillian, Al-Adwi, Yehya, Cucci, Marie Angele, Caldera, Fabrizio, Trotta, Francesco, Barrera, Giuseppina, Casini, Angela, Cavalli, Roberta, Pizzimenti, Stefania
Published in Toxicology in vitro (01.06.2020)

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Innovative Methods to Study Human Intestinal Drug Metabolism in Vitro: Precision-Cut Slices Compared with Ussing Chamber Preparations

Innovative Methods to Study Human Intestinal Drug Metabolism in Vitro: Precision-Cut Slices Compared with Ussing Chamber Preparations

by VAN DE KERKHOF, Esther G, UNGELL, Anna-Lena B, SJÖBERG, Asa K, DE JAGER, Marina H, HILGENDORF, Constanze, DE GRAAF, Inge A. M, GROOTHUIS, Geny M. M
Published in Drug metabolism and disposition (01.11.2006)

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Rifampicin Induces Gene, Protein, and Activity of P-Glycoprotein (ABCB1) in Human Precision-Cut Intestinal Slices

Rifampicin Induces Gene, Protein, and Activity of P-Glycoprotein (ABCB1) in Human Precision-Cut Intestinal Slices

by Martinec, Ondrej, Biel, Carin, de Graaf, Inge A. M., Huliciak, Martin, de Jong, Koert P., Staud, Frantisek, Cecka, Filip, Olinga, Peter, Vokral, Ivan, Cerveny, Lukas
Published in Frontiers in pharmacology (09.06.2021)

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Prenatal smoke exposure induces persistent Cyp2a5 methylation and increases nicotine metabolism in the liver of neonatal and adult male offspring

Prenatal smoke exposure induces persistent Cyp2a5 methylation and increases nicotine metabolism in the liver of neonatal and adult male offspring

by Lkhagvadorj, Khosbayar, Meyer, Karolin F., Verweij, Laura P., Kooistra, Wierd, Reinders-Luinge, Marjan, Dijkhuizen, Henk W., de Graaf, Inge A. M., Plösch, Torsten, Hylkema, Machteld N.
Published in Epigenetics (01.12.2020)

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Postnatal Smoke Exposure Further Increases the Hepatic Nicotine Metabolism in Prenatally Smoke Exposed Male Offspring and Is Linked with Aberrant Cyp2a5 Methylation

Postnatal Smoke Exposure Further Increases the Hepatic Nicotine Metabolism in Prenatally Smoke Exposed Male Offspring and Is Linked with Aberrant Cyp2a5 Methylation

by Lkhagvadorj, Khosbayar, Zeng, Zhijun, Meyer, Karolin F, Verweij, Laura P, Kooistra, Wierd, Reinders-Luinge, Marjan, Dijkhuizen, Henk W, de Graaf, Inge A M, Plösch, Torsten, Hylkema, Machteld N
Published in International journal of molecular sciences (26.12.2020)

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Rat precision-cut liver slices predict drug-induced cholestatic injury

Rat precision-cut liver slices predict drug-induced cholestatic injury

by Starokozhko, Viktoriia, Greupink, Rick, van de Broek, Petra, Soliman, Nashwa, Ghimire, Samiksha, de Graaf, Inge A. M., Groothuis, Geny M. M.
Published in Archives of toxicology (01.10.2017)

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Growth factors of stem cell niche extend the life-span of precision-cut intestinal slices in culture: A proof-of-concept study

Growth factors of stem cell niche extend the life-span of precision-cut intestinal slices in culture: A proof-of-concept study

by Bigaeva, Emilia, Bomers, Jordy J.M., Biel, Carin, Mutsaers, Henricus A.M., de Graaf, Inge A.M., Boersema, Miriam, Olinga, Peter
Published in Toxicology in vitro (01.09.2019)

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Effects of cryoprotectant addition and washout methods on the viability of precision-cut liver slices

Effects of cryoprotectant addition and washout methods on the viability of precision-cut liver slices

by Guan, Na, Blomsma, Sylvia A., van Midwoud, Paul M., Fahy, Gregory M., Groothuis, Geny M.M., de Graaf, Inge A.M.
Published in Cryobiology (01.12.2012)

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Exploring Porcine Precision-Cut Kidney Slices as a Model for Transplant-Related Ischemia-Reperfusion Injury

Exploring Porcine Precision-Cut Kidney Slices as a Model for Transplant-Related Ischemia-Reperfusion Injury

by van Furth, L. Annick, Leuvenink, Henri G. D., Seras, Lorina, de Graaf, Inge A. M., Olinga, Peter, van Leeuwen, L. Leonie
Published in Transplantology (Basel, Switzerland) (01.06.2022)

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CHARACTERIZATION OF RAT SMALL INTESTINAL AND COLON PRECISION-CUT SLICES AS AN IN VITRO SYSTEM FOR DRUG METABOLISM AND INDUCTION STUDIES

CHARACTERIZATION OF RAT SMALL INTESTINAL AND COLON PRECISION-CUT SLICES AS AN IN VITRO SYSTEM FOR DRUG METABOLISM AND INDUCTION STUDIES

by VAN DE KERKHOF, Esther G, DE GRAAF, Inge A. M, DE JAGER, Marina H, MEIJER, Dirk K. F, GROOTHUIS, Geny M. M
Published in Drug metabolism and disposition (01.11.2005)

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The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo

The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo

by Li, Ming, de Graaf, Inge A.M., van de Steeg, Evita, de Jager, Marina H., Groothuis, Geny M.M.
Published in Toxicology in vitro (01.04.2017)

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Ex vivo toxicological evaluation of experimental anticancer gold(i) complexes with lansoprazole-type ligands

Ex vivo toxicological evaluation of experimental anticancer gold(i) complexes with lansoprazole-type ligands

by Estrada-Ortiz, Natalia, Lopez-Gonzales, Elena, Woods, Ben, Stürup, Stefan, de Graaf, Inge A M, Groothuis, Geny M M, Casini, Angela
Published in Toxicology research (Cambridge) (01.11.2019)

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