Plk5, a Polo Box Domain-Only Protein with Specific Roles in Neuron Differentiation and Glioblastoma Suppression
de Cárcer, Guillermo, Escobar, Beatriz, Higuero, Alonso M., García, Laura, Ansón, Alejandra, Pérez, Gema, Mollejo, Manuela, Manning, Gerard, Meléndez, Bárbara, Abad-Rodríguez, José, Malumbres, Marcos
Published in Molecular and Cellular Biology (01.03.2011)
Published in Molecular and Cellular Biology (01.03.2011)
Get full text
Journal Article
Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization
García-Álvarez, Begoña, de Cárcer, Guillermo, Ibañez, Sonia, Bragado-Nilsson, Elisabeth, Montoya, Guillermo
Published in Proceedings of the National Academy of Sciences - PNAS (27.02.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (27.02.2007)
Get full text
Journal Article
Emerging cancer therapeutic opportunities by inhibiting mitotic kinases
Pérez de Castro, Ignacio, de Cárcer, Guillermo, Montoya, Guillermo, Malumbres, Marcos
Published in Current opinion in pharmacology (01.08.2008)
Published in Current opinion in pharmacology (01.08.2008)
Get full text
Journal Article
From Plk1 to Plk5: Functional evolution of polo-like kinases
de Cárcer, Guillermo, Manning, Gerard, Malumbres, Marcos
Published in Cell cycle (Georgetown, Tex.) (15.07.2011)
Published in Cell cycle (Georgetown, Tex.) (15.07.2011)
Get full text
Journal Article
Plk1 overexpression induces chromosomal instability and suppresses tumor development
de Cárcer, Guillermo, Venkateswaran, Sharavan Vishaan, Salgueiro, Lorena, El Bakkali, Aicha, Somogyi, Kalman, Rowald, Konstantina, Montañés, Pablo, Sanclemente, Manuel, Escobar, Beatriz, de Martino, Alba, McGranahan, Nicholas, Malumbres, Marcos, Sotillo, Rocío
Published in Nature communications (01.08.2018)
Published in Nature communications (01.08.2018)
Get full text
Journal Article
Targeting Mitotic Exit Leads to Tumor Regression In Vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ Phosphatase
Manchado, Eusebio, Guillamot, María, de Cárcer, Guillermo, Eguren, Manuel, Trickey, Michelle, García-Higuera, Irene, Moreno, Sergio, Yamano, Hiroyuki, Cañamero, Marta, Malumbres, Marcos
Published in Cancer cell (14.12.2010)
Published in Cancer cell (14.12.2010)
Get full text
Journal Article
Genetic interaction between PLK1 and downstream MCPH proteins in the control of centrosome asymmetry and cell fate during neural progenitor division
González-Martínez, José, Cwetsch, Andrzej W., Gilabert-Juan, Javier, Gómez, Jesús, Garaulet, Guillermo, Schneider, Paulina, de Cárcer, Guillermo, Mulero, Francisca, Caleiras, Eduardo, Megías, Diego, Porlan, Eva, Malumbres, Marcos
Published in Cell death and differentiation (01.08.2022)
Published in Cell death and differentiation (01.08.2022)
Get full text
Journal Article
Low Dose of Amino-Modified Nanoparticles Induces Cell Cycle Arrest
Kim, Jong Ah, Åberg, Christoffer, de Cárcer, Guillermo, Malumbres, Marcos, Salvati, Anna, Dawson, Kenneth A
Published in ACS nano (24.09.2013)
Published in ACS nano (24.09.2013)
Get full text
Journal Article
HIF2α Acts as an mTORC1 Activator through the Amino Acid Carrier SLC7A5
Elorza, Ainara, Soro-Arnáiz, Inés, Meléndez-Rodríguez, Florinda, Rodríguez-Vaello, Victoria, Marsboom, Glenn, de Cárcer, Guillermo, Acosta-Iborra, Bárbara, Albacete-Albacete, Lucas, Ordóñez, Angel, Serrano-Oviedo, Leticia, Giménez-Bachs, Jose Miguel, Vara-Vega, Alicia, Salinas, Antonio, Sánchez-Prieto, Ricardo, Martín del Río, Rafael, Sánchez-Madrid, Francisco, Malumbres, Marcos, Landázuri, Manuel O., Aragonés, Julián
Published in Molecular cell (14.12.2012)
Published in Molecular cell (14.12.2012)
Get full text
Journal Article
Crystal structure of the open conformation of the mammalian chaperonin CCT in complex with tubulin
Valpuesta, José M, Montoya, Guillermo, Muñoz, Inés G, Yébenes, Hugo, Zhou, Min, Mesa, Pablo, Serna, Marina, Park, Ah Young, Bragado-Nilsson, Elisabeth, Beloso, Ana, de Cárcer, Guillermo, Malumbres, Marcos, Robinson, Carol V
Published in Nature structural & molecular biology (01.01.2011)
Published in Nature structural & molecular biology (01.01.2011)
Get full text
Journal Article
PLK1 inhibition dampens NLRP3 inflammasome-elicited response in inflammatory disease models
Baldrighi, Marta, Doreth, Christian, Li, Yang, Zhao, Xiaohui, Warner, Emily, Chenoweth, Hannah, Kishore, Kamal, Umrania, Yagnesh, Minde, David-Paul, Thome, Sarah, Yu, Xian, Lu, Yuning, Knapton, Alice, Harrison, James, Clarke, Murray, Latz, Eicke, de Cárcer, Guillermo, Malumbres, Marcos, Ryffel, Bernhard, Bryant, Clare, Liu, Jinping, Lilley, Kathryn S, Mallat, Ziad, Li, Xuan
Published in The Journal of clinical investigation (01.11.2023)
Published in The Journal of clinical investigation (01.11.2023)
Get full text
Journal Article
Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis
de Cárcer, Guillermo, Wachowicz, Paulina, Martínez-Martínez, Sara, Oller, Jorge, Méndez-Barbero, Nerea, Escobar, Beatriz, González-Loyola, Alejandra, Takaki, Tohru, El Bakkali, Aicha, Cámara, Juan A, Jiménez-Borreguero, Luis J, Bustelo, Xosé R, Cañamero, Marta, Mulero, Francisca, de los Ángeles Sevilla, María, Montero, María Jose, Redondo, Juan Miguel, Malumbres, Marcos
Published in Nature medicine (01.08.2017)
Published in Nature medicine (01.08.2017)
Get full text
Journal Article
Overcoming PLK1 inhibitor resistance by targeting mevalonate pathway to impair AXL-TWIST axis in colorectal cancer
Solanes-Casado, Sonia, Cebrián, Arancha, Rodríguez-Remírez, María, Mahíllo, Ignacio, García-García, Laura, Río-Vilariño, Anxo, Baños, Natalia, de Cárcer, Guillermo, Monfort-Vengut, Ana, Castellano, Víctor, Fernández-Aceñero, Maria Jesús, García-Foncillas, Jesús, del Puerto-Nevado, Laura
Published in Biomedicine & pharmacotherapy (01.12.2021)
Published in Biomedicine & pharmacotherapy (01.12.2021)
Get full text
Journal Article
Aurora A drives early signalling and vesicle dynamics during T-cell activation
Blas-Rus, Noelia, Bustos-Morán, Eugenio, Pérez de Castro, Ignacio, de Cárcer, Guillermo, Borroto, Aldo, Camafeita, Emilio, Jorge, Inmaculada, Vázquez, Jesús, Alarcón, Balbino, Malumbres, Marcos, Martín-Cófreces, Noa B., Sánchez-Madrid, Francisco
Published in Nature communications (19.04.2016)
Published in Nature communications (19.04.2016)
Get full text
Journal Article
Targeting Cell Cycle Kinases for Cancer Therapy
DE CARCER, Guillermo, PEREZ DE CASTRO, Ignacio, MALUMBRES, Marcos
Published in Current medicinal chemistry (01.04.2007)
Published in Current medicinal chemistry (01.04.2007)
Get full text
Journal Article