Enasidenib, an inhibitor of mutant IDH2 proteins, induces durable remissions in older patients with newly diagnosed acute myeloid leukemia
Pollyea, Daniel A., Tallman, Martin S., de Botton, Stéphane, Kantarjian, Hagop M., Collins, Robert, Stein, Anthony S., Frattini, Mark G., Xu, Qiang, Tosolini, Alessandra, See, Wendy L., MacBeth, Kyle J., Agresta, Samuel V., Attar, Eyal C., DiNardo, Courtney D., Stein, Eytan M.
Published in Leukemia (01.11.2019)
Published in Leukemia (01.11.2019)
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Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers
Popovici-Muller, Janeta, Lemieux, René M, Artin, Erin, Saunders, Jeffrey O, Salituro, Francesco G, Travins, Jeremy, Cianchetta, Giovanni, Cai, Zhenwei, Zhou, Ding, Cui, Dawei, Chen, Ping, Straley, Kimberly, Tobin, Erica, Wang, Fang, David, Muriel D, Penard-Lacronique, Virginie, Quivoron, Cyril, Saada, Véronique, de Botton, Stéphane, Gross, Stefan, Dang, Lenny, Yang, Hua, Utley, Luke, Chen, Yue, Kim, Hyeryun, Jin, Shengfang, Gu, Zhiwei, Yao, Gui, Luo, Zhiyong, Lv, Xiaobing, Fang, Cheng, Yan, Liping, Olaharski, Andrew, Silverman, Lee, Biller, Scott, Su, Shin-San M, Yen, Katharine
Published in ACS medicinal chemistry letters (12.04.2018)
Published in ACS medicinal chemistry letters (12.04.2018)
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IDH1 and IDH2 mutations as novel therapeutic targets: current perspectives
Mondesir, Johanna, Willekens, Christophe, Touat, Mehdi, de Botton, Stéphane
Published in Journal of blood medicine (01.01.2016)
Published in Journal of blood medicine (01.01.2016)
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Book Review
Clinical pharmacokinetics and pharmacodynamics of ivosidenib in patients with advanced hematologic malignancies with an IDH1 mutation
Fan, Bin, Dai, David, DiNardo, Courtney D., Stein, Eytan, de Botton, Stéphane, Attar, Eyal C., Liu, Hua, Liu, Guowen, Lemieux, Ian, Agresta, Samuel V., Yang, Hua
Published in Cancer chemotherapy and pharmacology (01.05.2020)
Published in Cancer chemotherapy and pharmacology (01.05.2020)
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Journal Article
Outcomes of patients with IDH1-mutant relapsed or refractory acute myeloid leukemia receiving ivosidenib who proceeded to hematopoietic stem cell transplant
DiNardo, Courtney D., Stein, Eytan M., Pigneux, Arnaud, Altman, Jessica K., Collins, Robert, Erba, Harry P., Watts, Justin M., Uy, Geoffrey L., Winkler, Thomas, Wang, Hongfang, Choe, Sung, Liu, Hua, Wu, Bin, Kapsalis, Stephanie M., Roboz, Gail J., de Botton, Stéphane
Published in Leukemia (01.11.2021)
Published in Leukemia (01.11.2021)
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CDKN1A is a target for phagocytosis-mediated cellular immunotherapy in acute leukemia
Allouch, Awatef, Voisin, Laurent, Zhang, Yanyan, Raza, Syed Qasim, Lecluse, Yann, Calvo, Julien, Selimoglu-Buet, Dorothée, de Botton, Stéphane, Louache, Fawzia, Pflumio, Françoise, Solary, Eric, Perfettini, Jean-Luc
Published in Nature communications (08.11.2022)
Published in Nature communications (08.11.2022)
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Superior Long-Term Outcome With Idarubicin Compared With High-Dose Daunorubicin in Patients With Acute Myeloid Leukemia Age 50 Years and Older
GARDIN, Claude, CHEVRET, Sylvie, RENNEVILLE, Aline, BOISSEL, Nicolas, PREUDHOMME, Claude, TERRE, Christine, FENAUX, Pierre, BORDESSOULE, Dominique, CELLI-LEBRAS, Karine, CASTAIGNE, Sylvie, DOMBRET, Herve, PAUTAS, Cécile, TURLURE, Pascal, RAFFOUX, Emmanuel, THOMAS, Xavier, QUESNEL, Bruno, DE REVEL, Thierry, DE BOTTON, Stephane, GACHARD, Nathalie
Published in Journal of clinical oncology (20.01.2013)
Published in Journal of clinical oncology (20.01.2013)
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Ecto-calreticulin in immunogenic chemotherapy
Obeid, Michel, Tesniere, Antoine, Panaretakis, Theocharis, Tufi, Roberta, Joza, Nick, van Endert, Peter, Ghiringhelli, François, Apetoh, Lionel, Chaput, Nathalie, Flament, Caroline, Ullrich, Evelyn, de Botton, Stéphane, Zitvogel, Laurence, Kroemer, Guido
Published in Immunological reviews (01.12.2007)
Published in Immunological reviews (01.12.2007)
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Erlotinib antagonizes ABC transporters in acute myeloid leukemia
Lainey, Elodie, Sébert, Marie, Thépot, Sylvain, Scoazec, Marie, Bouteloup, Cyrielle, Leroy, Carole, De Botton, Stéphane, Galluzzi, Lorenzo, Fenaux, Pierre, Kroemer, Guido
Published in Cell cycle (Georgetown, Tex.) (01.11.2012)
Published in Cell cycle (Georgetown, Tex.) (01.11.2012)
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Erlotinib exhibits antineoplastic off-target effects in AML and MDS: a preclinical study
Boehrer, Simone, Adès, Lionel, Braun, Thorsten, Galluzzi, Lorenzo, Grosjean, Jennifer, Fabre, Claire, Le Roux, Génèviève, Gardin, Claude, Martin, Antoine, de Botton, Stéphane, Fenaux, Pierre, Kroemer, Guido
Published in Blood (15.02.2008)
Published in Blood (15.02.2008)
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PB1884: ENGAGING INNATE IMMUNITY: A PHASE 1 DOSE ESCALATION STUDY TO ASSESS SAFETY AND TOLERABILITY OF AFM28 MONOTHERAPY IN PATIENTS WITH RELAPSED/REFRACTORY CD123‐POSITIVE ACUTE MYELOID LEUKEMIA (AML)
Arnan, Montserrat, Montesinos, Pau, Botton, Stéphane, Recher, Christian, Wunderle, Lydia, Emig, Michael, Harstrick, Andreas, Pietzko, Kerstin, Pinto, Sheena, Ravenstijn, Paulien, Daver, Naval
Published in HemaSphere (08.08.2023)
Published in HemaSphere (08.08.2023)
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An activating mutation in the CSF3R gene induces a hereditary chronic neutrophilia
Plo, Isabelle, Zhang, Yanyan, Le Couédic, Jean-Pierre, Nakatake, Mayuka, Boulet, Jean-Michel, Itaya, Miki, Smith, Steven O, Debili, Najet, Constantinescu, Stefan N, Vainchenker, William, Louache, Fawzia, de Botton, Stéphane
Published in The Journal of experimental medicine (03.08.2009)
Published in The Journal of experimental medicine (03.08.2009)
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PB1773: AML AND MDS WITH RARA OVEREXPRESSION: MOLECULAR AND CLINICAL FEATURES OF PATIENTS ENROLLED IN A PHASE 2 TRIAL EVALUATING TAMIBAROTENE‐BASED THERAPY
Botton, Stéphane, Cluzeau, Thomas, Vigil, Carlos, Cook, Rachel, Rousselot, Philippe, Rizzieri, David, Liesveld, Jane, Fenaux, Pierre, Braun, Thorsten, Pigneux, Arnaud, Peterlin, Pierre, Paul, Sofia, Rajagopal, Nisha, Carulli, John, Roth, David, Volkert, Angela, Malak, Tanya Abdul, Kelly, Michael, Klimek, Virginia, Stein, Eytan
Published in HemaSphere (08.08.2023)
Published in HemaSphere (08.08.2023)
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Infectious complications in adult acute myeloid leukemia: analysis of the Acute Leukemia French Association-9802 prospective multicenter clinical trial
Cannas, Giovanna, Pautas, Cécile, Raffoux, Emmanuel, Quesnel, Bruno, Botton, Stéphane de, Revel, Thierry de, Reman, Oumedaly, Gardin, Claude, Elhamri, Mohamed, Boissel, Nicolas, Fenaux, Pierre, Michallet, Mauricette, Castaigne, Sylvie, Dombret, Hervé, Thomas, Xavier
Published in Leukemia & lymphoma (01.06.2012)
Published in Leukemia & lymphoma (01.06.2012)
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Hypomethylating agents reactivate FOXO3A in acute myeloid leukemia
Thépot, Sylvain, Lainey, Elodie, Cluzeau, Thomas, Sébert, Marie, Leroy, Carole, Adès, Lionel, Tailler, Maximilien, Galluzzi, Lorenzo, Baran-Marszak, Fanny, Roudot, Hervé, Eclache, Virginie, Gardin, Claude, de Botton, Stéphane, Auberger, Patrick, Fenaux, Pierre, Kroemer, Guido, Boehrer, Simone
Published in Cell cycle (Georgetown, Tex.) (15.07.2011)
Published in Cell cycle (Georgetown, Tex.) (15.07.2011)
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Erlotinib antagonizes constitutive activation of SRC family kinases and mTOR in acute myeloid leukemia
Boehrer, Simone, Galluzzi, Lorenzo, Lainey, Elodie, Bouteloup, Cyrielle, Tailler, Maximilien, Harper, Francis, Pierron, Gérard, Adès, Lionel, Thépot, Sylvain, Sébert, Marie, Gardin, Claude, de Botton, Stéphane, Fenaux, Pierre, Kroemer, Guido
Published in Cell cycle (Georgetown, Tex.) (15.09.2011)
Published in Cell cycle (Georgetown, Tex.) (15.09.2011)
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Immune stimulation during chemotherapy increases incidence of acute graft versus host disease in acute myeloid leukemia: a study on behalf of SFGM-TC and ALFA
Wang, Lining, Raffoux, Emmanuel, Thomas, Xavier, Yakoub-Agha, Ibrahim, Bouhris, Jean-Henri, Botton, Stéphane de, Michallet, Mauricette, Quoc, Stéphanie Nguyen, Troussard, Xavier, Deconinck, Eric, Caillot, Denis, Turlure, Pascal, Vigouroux, Stéphane, Pigneux, Arnaud, Huynh, Anne, Malfuson, Jean-Valère, Loschi, Michael, Socie, Gerard, Dombret, Hervé, de la Tour, Régis Peffault, Cluzeau, Thomas
Published in Leukemia research (01.03.2017)
Published in Leukemia research (01.03.2017)
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Chromosomal minimal critical regions in therapy-related leukemia appear different from those of de novo leukemia by high-resolution aCGH
Itzhar, Nathalie, Dessen, Philippe, Toujani, Saloua, Auger, Nathalie, Preudhomme, Claude, Richon, Catherine, Lazar, Vladimir, Saada, Véronique, Bennaceur, Anelyse, Bourhis, Jean Henri, de Botton, Stéphane, Bernheim, Alain
Published in PloS one (14.02.2011)
Published in PloS one (14.02.2011)
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A novel effect of DNA methyltransferase and histone deacetylase inhibitors : NFκB inhibition in malignant myeloblasts
Fabre, Claire, Grosjean, Jennifer, Tailler, Maximilien, Boehrer, Simone, Adès, Lionel, Perfettini, Jean-Luc, de Botton, Stéphane, Fenaux, Pierre, Kroemer, Guido
Published in Cell cycle (Georgetown, Tex.) (15.07.2008)
Published in Cell cycle (Georgetown, Tex.) (15.07.2008)
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Germline RUNX1 Intragenic Deletion: Implications for Accurate Diagnosis of FPD/AML
Duployez, Nicolas, Martin, Jean‐Edouard, Khalife‐Hachem, Sabine, Benkhelil, Ryane, Saada, Véronique, Marzac, Christophe, Auger, Nathalie, Marceau‐Renaut, Alice, Favier, Rémi, Ballerini, Paola, Caron, Olivier, Baruchel, André, Botton, Stéphane, Preudhomme, Claude, Micol, Jean‐Baptiste, Raslova, Hana, Antony‐Debré, Iléana
Published in HemaSphere (01.06.2019)
Published in HemaSphere (01.06.2019)
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