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Long Non-coding RNAs: Major Regulators of Cell Stress in Cancer
Connerty, Patrick, Lock, Richard B, de Bock, Charles E
Published in Frontiers in oncology (20.03.2020)
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Sleeping Giants: Emerging Roles for the Fat Cadherins in Health and Disease
Sadeqzadeh, Elham, de Bock, Charles E., Thorne, Rick F.
Published in Medicinal research reviews (01.01.2014)
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PU.1 eviction at lymphocyte-specific chromatin domains mediates glucocorticoid response in acute lymphoblastic leukemia
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Published in Nature communications (08.11.2024)
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Development of siRNA-Loaded Lipid Nanoparticles Targeting Long Non-Coding RNA LINC01257 as a Novel and Safe Therapeutic Approach for t(8;21) Pediatric Acute Myeloid Leukemia
Connerty, Patrick, Moles, Ernest, de Bock, Charles E., Jayatilleke, Nisitha, Smith, Jenny L., Meshinchi, Soheil, Mayoh, Chelsea, Kavallaris, Maria, Lock, Richard B.
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SIX6 is a TAL1-regulated transcription factor in T-ALL and associated with inferior outcome
Laukkanen, Saara, Oksa, Laura, Nikkilä, Atte, Lahnalampi, Mari, Parikka, Mataleena, Seki, Masafumi, Takita, Junko, Degerman, Sofie, de Bock, Charles E., Heinäniemi, Merja, Lohi, Olli
Published in Leukemia & lymphoma (2020)
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miR-139-5p Modulates Radiotherapy Resistance in Breast Cancer by Repressing Multiple Gene Networks of DNA Repair and ROS Defense
Pajic, Marina, Froio, Danielle, Daly, Sheridan, Doculara, Louise, Millar, Ewan, Graham, Peter H, Drury, Alison, Steinmann, Angela, de Bock, Charles E, Boulghourjian, Alice, Zaratzian, Anaiis, Carroll, Susan, Toohey, Joanne, O'Toole, Sandra A, Harris, Adrian L, Buffa, Francesca M, Gee, Harriet E, Hollway, Georgina E, Molloy, Timothy J
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Targeting hyperactive platelet-derived growth factor receptor-β signaling in T-cell acute lymphoblastic leukemia and lymphoma
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Published in Haematologica (Roma) (01.05.2024)
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Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia
Van Thillo, Quentin, De Bie, Jolien, Seneviratne, Janith A., Demeyer, Sofie, Omari, Sofia, Balachandran, Anushree, Zhai, Vicki, Tam, Wai L., Sweron, Bram, Geerdens, Ellen, Gielen, Olga, Provost, Sarah, Segers, Heidi, Boeckx, Nancy, Marshall, Glenn M., Cheung, Belamy B., Isobe, Kiyotaka, Kato, Itaru, Takita, Junko, Amos, Timothy G., Deveson, Ira W., McCalmont, Hannah, Lock, Richard B., Oxley, Ethan P., Garwood, Maximilian M., Dickins, Ross A., Uyttebroeck, Anne, Carter, Daniel R., Cools, Jan, de Bock, Charles E.
Published in Nature communications (06.07.2021)
Published in Nature communications (06.07.2021)
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HMGN1 plays a significant role in CRLF2 driven Down Syndrome leukemia and provides a potential therapeutic target in this high-risk cohort
Page, Elyse C., Heatley, Susan L., Eadie, Laura N., McClure, Barbara J., de Bock, Charles E., Omari, Sofia, Yeung, David T., Hughes, Timothy P., Thomas, Paul Q., White, Deborah L.
Published in Oncogene (04.02.2022)
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Quantitative phosphoproteomics uncovers synergy between DNA-PK and FLT3 inhibitors in acute myeloid leukaemia
Murray, Heather C., Enjeti, Anoop K., Kahl, Richard G. S., Flanagan, Hayley M., Sillar, Jonathan, Skerrett-Byrne, David A., Al Mazi, Juhura G., Au, Gough G., de Bock, Charles E., Evans, Kathryn, Smith, Nathan D., Anderson, Amanda, Nixon, Brett, Lock, Richard B., Larsen, Martin R., Verrills, Nicole M., Dun, Matthew D.
Published in Leukemia (01.06.2021)
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T-cell acute lymphoblastic leukemias express a unique truncated FAT1 isoform that cooperates with NOTCH1 in leukemia development
de Bock, Charles E, Down, Michelle, Baidya, Kinsha, Sweron, Bram, Boyd, Andrew W, Fiers, Mark, Burns, Gordon F, Molloy, Timothy J, Lock, Richard B, Soulier, Jean, Taghon, Tom, Van Vlierberghe, Pieter, Cools, Jan, Holst, Jeff, Thorne, Rick F
Published in Haematologica (Roma) (01.05.2019)
Published in Haematologica (Roma) (01.05.2019)
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The third generation AKR1C3-activated prodrug, ACHM-025, eradicates disease in preclinical models of aggressive T-cell acute lymphoblastic leukemia
Toscan, Cara E., McCalmont, Hannah, Ashoorzadeh, Amir, Lin, Xiaojing, Fu, Zhe, Doculara, Louise, Kosasih, Hansen J., Cadiz, Roxanne, Zhou, Anthony, Williams, Sarah, Evans, Kathryn, Khalili, Faezeh, Cai, Ruilin, Yeats, Kristy L., Gifford, Andrew J., Pickford, Russell, Mayoh, Chelsea, Xie, Jinhan, Henderson, Michelle J., Trahair, Toby N., Patterson, Adam V., Smaill, Jeff B., de Bock, Charles E., Lock, Richard B.
Published in Blood cancer journal (New York) (06.11.2024)
Published in Blood cancer journal (New York) (06.11.2024)
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A comprehensive inventory of TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia through polyA+ and total RNA sequencing
Verboom, Karen, Van Loocke, Wouter, Volders, Pieter-Jan, Decaesteker, Bieke, Avila Cobos, Francisco, Bornschein, Simon, de Bock, Charles E, Kalender Atak, Zeynep, Clappier, Emmanuelle, Aerts, Stein, Cools, Jan, Soulier, Jean, Taghon, Tom, Van Vlierberghe, Pieter, Vandesompele, Jo, Speleman, Frank, Durinck, Kaat
Published in Haematologica (Roma) (01.12.2018)
Published in Haematologica (Roma) (01.12.2018)
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Unusual PDGFRB fusion reveals novel mechanism of kinase activation in Ph-like B-ALL
Sadras, Teresa, Jalud, Fatimah B., Kosasih, Hansen J., Horne, Christopher R., Brown, Lauren M., El-Kamand, Sam, de Bock, Charles E., McAloney, Lachlan, Ng, Ashley P., Davidson, Nadia M., Ludlow, Louise E. A., Oshlack, Alicia, Cowley, Mark J., Khaw, Seong L., Murphy, James M., Ekert, Paul G.
Published in Leukemia (01.04.2023)
Published in Leukemia (01.04.2023)
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The CCR4-NOT complex is a tumor suppressor in Drosophila melanogaster eye cancer models
Vicente, Carmen, Stirparo, Rocco, Demeyer, Sofie, de Bock, Charles E, Gielen, Olga, Atkins, Mardelle, Yan, Jiekun, Halder, Georg, Hassan, Bassem A, Cools, Jan
Published in Journal of hematology and oncology (25.08.2018)
Published in Journal of hematology and oncology (25.08.2018)
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Shwachman–Bodian–Diamond syndrome (SBDS) protein is a direct inhibitor of protein phosphatase 2A (PP2A) activity and overexpressed in acute myeloid leukaemia
Dun, Matthew D., Mannan, Abdul, Rigby, Callum J., Butler, Stephen, Toop, Hamish D., Beck, Dominik, Connerty, Patrick, Sillar, Jonathan, Kahl, Richard G. S., Duchatel, Ryan J., Germon, Zacary, Faulkner, Sam, Chi, Mengna, Skerrett-Byrne, David, Murray, Heather C., Flanagan, Hayley, Almazi, Juhura G., Hondermarck, Hubert, Nixon, Brett, De Iuliis, Geoff, Chamberlain, Janis, Alvaro, Frank, de Bock, Charles E., Morris, Jonathan C., Enjeti, Anoop K., Verrills, Nicole M.
Published in Leukemia (01.12.2020)
Published in Leukemia (01.12.2020)
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