Pembrolizumab Exposure-Response Assessments Challenged by Association of Cancer Cachexia and Catabolic Clearance
Turner, David C, Kondic, Anna G, Anderson, Keaven M, Robinson, Andrew G, Garon, Edward B, Riess, Jonathan Wesley, Jain, Lokesh, Mayawala, Kapil, Kang, Jiannan, Ebbinghaus, Scot W, Sinha, Vikram, de Alwis, Dinesh P, Stone, Julie A
Published in Clinical cancer research (01.12.2018)
Published in Clinical cancer research (01.12.2018)
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Journal Article
Exposure–Response Analyses for Belzutifan to Inform Dosing Considerations and Labeling
Marathe, Dhananjay D., Jauslin, Petra M., Jan Kleijn, Huub, De Miranda Silva, Carolina, Chain, Anne, Abraham, Anson K., Kauh, Eunkyung A., Liu, Yanfang, Perini, Rodolfo F., Alwis, Dinesh P. de, Jain, Lokesh
Published in Journal of clinical pharmacology (01.10.2024)
Published in Journal of clinical pharmacology (01.10.2024)
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Journal Article
Tumor dynamics in patients with solid tumors treated with pembrolizumab beyond disease progression
Topp, Brian G., Channavazzala, Madhav, Mayawala, Kapil, De Alwis, Dinesh P., Rubin, Eric, Snyder, Alexandra, Wolchok, Jedd D., Ribas, Antoni
Published in Cancer cell (11.09.2023)
Published in Cancer cell (11.09.2023)
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Rendering the 3 + 3 Design to Rest: More Efficient Approaches to Oncology Dose-Finding Trials in the Era of Targeted Therapy
Nie, Lei, Rubin, Eric H, Mehrotra, Nitin, Pinheiro, José, Fernandes, Laura L, Roy, Amit, Bailey, Stuart, de Alwis, Dinesh P
Published in Clinical cancer research (01.06.2016)
Published in Clinical cancer research (01.06.2016)
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A six-weekly dosing schedule for pembrolizumab in patients with cancer based on evaluation using modelling and simulation
Lala, Mallika, Li, Tommy Ruosi, de Alwis, Dinesh P., Sinha, Vikram, Mayawala, Kapil, Yamamoto, Noboru, Siu, Lillian L., Chartash, Elliot, Aboshady, Hesham, Jain, Lokesh
Published in European journal of cancer (1990) (01.05.2020)
Published in European journal of cancer (1990) (01.05.2020)
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Baseline Tumor Size Is an Independent Prognostic Factor for Overall Survival in Patients with Melanoma Treated with Pembrolizumab
Joseph, Richard W, Elassaiss-Schaap, Jeroen, Kefford, Richard, Hwu, Wen-Jen, Wolchok, Jedd D, Joshua, Anthony M, Ribas, Antoni, Hodi, F Stephen, Hamid, Omid, Robert, Caroline, Daud, Adil, Dronca, Roxana, Hersey, Peter, Weber, Jeffrey S, Patnaik, Amita, de Alwis, Dinesh P, Perrone, Andrea, Zhang, Jin, Kang, S Peter, Ebbinghaus, Scot, Anderson, Keaven M, Gangadhar, Tara C
Published in Clinical cancer research (15.10.2018)
Published in Clinical cancer research (15.10.2018)
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Journal Article
Progress and Opportunities to Advance Clinical Cancer Therapeutics Using Tumor Dynamic Models
Bruno, René, Bottino, Dean, de Alwis, Dinesh P, Fojo, Antonio T, Guedj, Jérémie, Liu, Chao, Swanson, Kristin R, Zheng, Jenny, Zheng, Yanan, Jin, Jin Y
Published in Clinical cancer research (15.04.2020)
Published in Clinical cancer research (15.04.2020)
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Journal Article
Model Informed Drug Development: Novel Oncology Agents are Lost in Translation
Mayawala, Kapil, de Alwis, Dinesh P, Sachs, Jeffrey R
Published in Clinical cancer research (15.11.2019)
Published in Clinical cancer research (15.11.2019)
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Journal Article
Considerations in the design and development of transport inhibitors as adjuncts to drug therapy
Dantzig, Anne H, de Alwis, Dinesh P, Burgess, Michael
Published in Advanced drug delivery reviews (21.01.2003)
Published in Advanced drug delivery reviews (21.01.2003)
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Journal Article
Pivotal Dose of Pembrolizumab: A Dose-Finding Strategy for Immuno-Oncology
Li, Tommy R, Chatterjee, Manash, Lala, Mallika, Abraham, Anson K, Freshwater, Tomoko, Jain, Lokesh, Sinha, Vikram, de Alwis, Dinesh P, Mayawala, Kapil
Published in Clinical pharmacology and therapeutics (01.07.2021)
Published in Clinical pharmacology and therapeutics (01.07.2021)
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Journal Article
Evaluation of dosing strategy for pembrolizumab for oncology indications
Freshwater, Tomoko, Kondic, Anna, Ahamadi, Malidi, Li, Claire H, de Greef, Rik, de Alwis, Dinesh, Stone, Julie A
Published in Journal for immunotherapy of cancer (16.05.2017)
Published in Journal for immunotherapy of cancer (16.05.2017)
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A Phase I Trial of a Potent P-Glycoprotein Inhibitor, Zosuquidar Trihydrochloride (LY335979), Administered Intravenously in Combination with Doxorubicin in Patients with Advanced Malignancy
SANDLER, Alan, GORDON, Michael, JORDAN, Christopher, BURGESS, Michael, SLAPAK, Christopher A, DE ALWIS, Dinesh P, POULIQUEN, Isabelle, GREEN, Lisa, MARDER, Phil, CHAUDHARY, Ajai, FIFE, Karen, BATTIATO, Linda, SWEENEY, Christopher
Published in Clinical cancer research (15.05.2004)
Published in Clinical cancer research (15.05.2004)
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Corrigendum to “A six-weekly (Q6W) dosing schedule for pembrolizumab in patients with cancer based on evaluation using modelling and simulation” [Eur J Canc 131 (2020) 68–75]
Lala, Mallika, Li, Tommy Ruosi, de Alwis, Dinesh P., Sinha, Vikram, Mayawala, Kapil, Li, Mengyao, Yamamoto, Noboru, Siu, Lillian L., Chartash, Elliot, Aboshady, Hesham, Jain, Lokesh
Published in European journal of cancer (1990) (01.02.2021)
Published in European journal of cancer (1990) (01.02.2021)
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Modulation of intratumoural myeloid cells, the hallmark of the anti-tumour efficacy induced by a triple combination: tumour-associated peptide, TLR-3 ligand and α-PD-1
Zalba, Sara, Belsúe, Virginia, Topp, Brian, de Alwis, Dinesh, Alvarez, Maite, Trocóniz, Iñaki F., Berraondo, Pedro, Garrido, María J.
Published in British journal of cancer (30.03.2021)
Published in British journal of cancer (30.03.2021)
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Journal Article
Experimental Medicine Study to Measure Immune Checkpoint Receptors PD‐1 and GITR Turnover Rates In Vivo in Humans
Lassman, Michael E., Chappell, Derek L., McAvoy, Thomas, Cheng, Amy, Alwis, Dinesh P., Pruitt, Scott K., Laterza, Omar F., Li, Claire, Stoch, Aubrey, Mayawala, Kapil
Published in Clinical pharmacology and therapeutics (01.06.2021)
Published in Clinical pharmacology and therapeutics (01.06.2021)
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A phase I study of oral LY293111 given daily in combination with irinotecan in patients with solid tumours
Baetz, Tara, Eisenhauer, Elizabeth, Siu, Lillian, MacLean, Martha, Doppler, Karen, Walsh, Wendy, Fisher, Bryn, Khan, Azhar Z, de Alwis, Dinesh P, Weitzman, A, Brail, Leslie H, Moore, Malcolm
Published in Investigational new drugs (01.06.2007)
Published in Investigational new drugs (01.06.2007)
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Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-β kinase antagonist, in mice
Bueno, Lorea, de Alwis, Dinesh P, Pitou, Celine, Yingling, Jonathan, Lahn, Michael, Glatt, Sophie, Trocóniz, Iñaki F
Published in European journal of cancer (1990) (01.01.2008)
Published in European journal of cancer (1990) (01.01.2008)
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Journal Article
Phase I Study of Docetaxel in Combination with the P-Glycoprotein Inhibitor, Zosuquidar, in Resistant Malignancies
FRACASSE, Paula M, GOLDSTEIN, Lori J, BURGESS, Michael F, SLAPAK, Christopher A, SCHELLENS, Jan H. M, DE ALWIS, Dinesh P, RADER, Janet S, ARQUETTE, Matthew A, GOODNER, Sherry A, WRIGHT, Lisa P, FEARS, Carole L, GAZAK, Robert J, ANDRE, Valerie A. M
Published in Clinical cancer research (01.11.2004)
Published in Clinical cancer research (01.11.2004)
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