Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung
Lafkas, Daniel, Shelton, Amy, Chiu, Cecilia, de Leon Boenig, Gladys, Chen, Yongmei, Stawicki, Scott S., Siltanen, Christian, Reichelt, Mike, Zhou, Meijuan, Wu, Xiumin, Eastham-Anderson, Jeffrey, Moore, Heather, Roose-Girma, Meron, Chinn, Yvonne, Hang, Julie Q., Warming, Søren, Egen, Jackson, Lee, Wyne P., Austin, Cary, Wu, Yan, Payandeh, Jian, Lowe, John B., Siebel, Christian W.
Published in Nature (London) (03.12.2015)
Published in Nature (London) (03.12.2015)
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Journal Article
Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc
Fauber, Benjamin P., de Leon Boenig, Gladys, Burton, Brenda, Eidenschenk, Céline, Everett, Christine, Gobbi, Alberto, Hymowitz, Sarah G., Johnson, Adam R., Liimatta, Marya, Lockey, Peter, Norman, Maxine, Ouyang, Wenjun, René, Olivier, Wong, Harvey
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
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Journal Article
A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors
Bronner, Sarah M, Murray, Jeremy, Romero, F. Anthony, Lai, Kwong Wah, Tsui, Vickie, Cyr, Patrick, Beresini, Maureen H, de leon Boenig, Gladys, Chen, Zhongguo, Choo, Edna F, Clark, Kevin R, Crawford, Terry D, Jayaram, Hariharan, Kaufman, Susan, Li, Ruina, Li, Yingjie, Liao, Jiangpeng, Liang, Xiaorong, Liu, Wenfeng, Ly, Justin, Maher, Jonathan, Wai, John, Wang, Fei, Zheng, Aijun, Zhu, Xiaoyu, Magnuson, Steven
Published in Journal of medicinal chemistry (28.12.2017)
Published in Journal of medicinal chemistry (28.12.2017)
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Journal Article
Antibody interfaces revealed through structural mining
Yin, Yizhou, Romei, Matthew G., Sankar, Kannan, Pal, Lipika R., Hoi, Kam Hon, Yang, Yanli, Leonard, Brandon, De Leon Boenig, Gladys, Kumar, Nikit, Matsumoto, Marissa, Payandeh, Jian, Harris, Seth F., Moult, John, Lazar, Greg A.
Published in Computational and structural biotechnology journal (01.01.2022)
Published in Computational and structural biotechnology journal (01.01.2022)
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Journal Article
GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP)
Romero, F. Anthony, Murray, Jeremy, Lai, Kwong Wah, Tsui, Vickie, Albrecht, Brian K, An, Le, Beresini, Maureen H, de Leon Boenig, Gladys, Bronner, Sarah M, Chan, Emily W, Chen, Kevin X, Chen, Zhongguo, Choo, Edna F, Clagg, Kyle, Clark, Kevin, Crawford, Terry D, Cyr, Patrick, de Almeida Nagata, Denise, Gascoigne, Karen E, Grogan, Jane L, Hatzivassiliou, Georgia, Huang, Wei, Hunsaker, Thomas L, Kaufman, Susan, Koenig, Stefan G, Li, Ruina, Li, Yingjie, Liang, Xiaorong, Liao, Jiangpeng, Liu, Wenfeng, Ly, Justin, Maher, Jonathan, Masui, Colin, Merchant, Mark, Ran, Yingqing, Taylor, Alexander M, Wai, John, Wang, Fei, Wei, Xiaocang, Yu, Dong, Zhu, Bing-Yan, Zhu, Xiaoyu, Magnuson, Steven
Published in Journal of medicinal chemistry (22.11.2017)
Published in Journal of medicinal chemistry (22.11.2017)
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Journal Article
Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300
Crawford, Terry D, Romero, F. Anthony, Lai, Kwong Wah, Tsui, Vickie, Taylor, Alexander M, de Leon Boenig, Gladys, Noland, Cameron L, Murray, Jeremy, Ly, Justin, Choo, Edna F, Hunsaker, Thomas L, Chan, Emily W, Merchant, Mark, Kharbanda, Samir, Gascoigne, Karen E, Kaufman, Susan, Beresini, Maureen H, Liao, Jiangpeng, Liu, Wenfeng, Chen, Kevin X, Chen, Zhongguo, Conery, Andrew R, Côté, Alexandre, Jayaram, Hariharan, Jiang, Ying, Kiefer, James R, Kleinheinz, Tracy, Li, Yingjie, Maher, Jonathan, Pardo, Eneida, Poy, Florence, Spillane, Kerry L, Wang, Fei, Wang, Jian, Wei, Xiaocang, Xu, Zhaowu, Xu, Zhongya, Yen, Ivana, Zawadzke, Laura, Zhu, Xiaoyu, Bellon, Steven, Cummings, Richard, Cochran, Andrea G, Albrecht, Brian K, Magnuson, Steven
Published in Journal of medicinal chemistry (08.12.2016)
Published in Journal of medicinal chemistry (08.12.2016)
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Journal Article
Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9
Holliday, Michael J., Ferrao, Ryan, de Leon Boenig, Gladys, Estevez, Alberto, Helgason, Elizabeth, Rohou, Alexis, Dueber, Erin C., Fairbrother, Wayne J.
Published in The Journal of biological chemistry (26.10.2018)
Published in The Journal of biological chemistry (26.10.2018)
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Journal Article
Reduction in lipophilicity improved the solubility, plasma–protein binding, and permeability of tertiary sulfonamide RORc inverse agonists
Fauber, Benjamin P., René, Olivier, de Leon Boenig, Gladys, Burton, Brenda, Deng, Yuzhong, Eidenschenk, Céline, Everett, Christine, Gobbi, Alberto, Hymowitz, Sarah G., Johnson, Adam R., La, Hank, Liimatta, Marya, Lockey, Peter, Norman, Maxine, Ouyang, Wenjun, Wang, Weiru, Wong, Harvey
Published in Bioorganic & medicinal chemistry letters (15.08.2014)
Published in Bioorganic & medicinal chemistry letters (15.08.2014)
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Journal Article
Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members
Yang, Yanli, Yeh, Sherry H, Madireddi, Shravan, Matochko, Wadim L, Gu, Chen, Pacheco Sanchez, Patricia, Ultsch, Mark, De Leon Boenig, Gladys, Harris, Seth F, Leonard, Brandon, Scales, Suzie J, Zhu, Jing W, Christensen, Erin, Hang, Julie Q, Brezski, Randall J, Marsters, Scot, Ashkenazi, Avi, Sukumaran, Siddharth, Chiu, Henry, Cubas, Rafael, Kim, Jeong M, Lazar, Greg A
Published in mAbs (18.08.2019)
Published in mAbs (18.08.2019)
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Journal Article
Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300
Lai, Kwong Wah, Romero, F. Anthony, Tsui, Vickie, Beresini, Maureen H., de Leon Boenig, Gladys, Bronner, Sarah M., Chen, Kevin, Chen, Zhongguo, Choo, Edna F., Crawford, Terry D., Cyr, Patrick, Kaufman, Susan, Li, Yingjie, Liao, Jiangpeng, Liu, Wenfeng, Ly, Justin, Murray, Jeremy, Shen, Weichao, Wai, John, Wang, Fei, Zhu, Caicai, Zhu, Xiaoyu, Magnuson, Steven
Published in Bioorganic & medicinal chemistry letters (01.01.2018)
Published in Bioorganic & medicinal chemistry letters (01.01.2018)
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Journal Article
Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637)
Taylor, Alexander M, Côté, Alexandre, Hewitt, Michael C, Pastor, Richard, Leblanc, Yves, Nasveschuk, Christopher G, Romero, F. Anthony, Crawford, Terry D, Cantone, Nico, Jayaram, Hariharan, Setser, Jeremy, Murray, Jeremy, Beresini, Maureen H, de Leon Boenig, Gladys, Chen, Zhongguo, Conery, Andrew R, Cummings, Richard T, Dakin, Leslie A, Flynn, E. Megan, Huang, Oscar W, Kaufman, Susan, Keller, Patricia J, Kiefer, James R, Lai, Tommy, Li, Yingjie, Liao, Jiangpeng, Liu, Wenfeng, Lu, Henry, Pardo, Eneida, Tsui, Vickie, Wang, Jian, Wang, Yongyun, Xu, Zhaowu, Yan, Fen, Yu, Dong, Zawadzke, Laura, Zhu, Xiaoqin, Zhu, Xiaoyu, Sims, Robert J, Cochran, Andrea G, Bellon, Steve, Audia, James E, Magnuson, Steven, Albrecht, Brian K
Published in ACS medicinal chemistry letters (12.05.2016)
Published in ACS medicinal chemistry letters (12.05.2016)
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Journal Article
The Crystal Structure of the Catalytic Domain of the NF-κB Inducing Kinase Reveals a Narrow but Flexible Active Site
de Leon-Boenig, Gladys, Bowman, Krista K., Feng, Jianwen A., Crawford, Terry, Everett, Christine, Franke, Yvonne, Oh, Angela, Stanley, Mark, Staben, Steven T., Starovasnik, Melissa A., Wallweber, Heidi J.A., Wu, Jiansheng, Wu, Lawren C., Johnson, Adam R., Hymowitz, Sarah G.
Published in Structure (London) (10.10.2012)
Published in Structure (London) (10.10.2012)
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Journal Article
A reversed sulfonamide series of selective RORc inverse agonists
van Niel, Monique B., Fauber, Benjamin P., Cartwright, Matthew, Gaines, Simon, Killen, Jonathan C., Rene, Olivier, Ward, Stuart I., Boenig, Gladys de Leon, Deng, Yuzhong, Eidenschenk, Celine, Everett, Christine, Gancia, Emanuela, Ganguli, Arunima, Gobbi, Alberto, Hawkins, Julie, Johnson, Adam R., Kiefer, James R., La, Hank, Lockey, Peter, Norman, Maxine, Ouyang, Wenjun, Qin, Ann, Wakes, Nicole, Waszkowycz, Bohdan, Wong, Harvey
Published in Bioorganic & medicinal chemistry letters (15.12.2014)
Published in Bioorganic & medicinal chemistry letters (15.12.2014)
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Journal Article
A reversed sulfonamide series of selective RORc inverse agonists
van Niel, Monique B., Fauber, Benjamin P., Cartwright, Matthew, Gaines, Simon, Killen, Jonathan C., René, Olivier, Ward, Stuart I., de Leon Boenig, Gladys, Deng, Yuzhong, Eidenschenk, Céline, Everett, Christine, Gancia, Emanuela, Ganguli, Arunima, Gobbi, Alberto, Hawkins, Julie, Johnson, Adam R., Kiefer, James R., La, Hank, Lockey, Peter, Norman, Maxine, Ouyang, Wenjun, Qin, Ann, Wakes, Nicole, Waszkowycz, Bohdan, Wong, Harvey
Published in Bioorganic & medicinal chemistry letters (01.12.2014)
Published in Bioorganic & medicinal chemistry letters (01.12.2014)
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Journal Article
Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma
Bronner, Sarah M., Merrick, Karl A., Murray, Jeremy, Salphati, Laurent, Moffat, John G., Pang, Jodie, Sneeringer, Christopher J., Dompe, Nicholas, Cyr, Patrick, Purkey, Hans, Boenig, Gladys de Leon, Li, Jun, Kolesnikov, Aleksandr, Larouche-Gauthier, Robin, Lai, Kwong Wah, Shen, Xiaoli, Aubert-Nicol, Samuel, Chen, Yi-Chen, Cheong, Jonathan, Crawford, James J., Hafner, Marc, Haghshenas, Pouyan, Jakalian, Araz, Leclerc, Jean-Philippe, Lim, Ngiap-Kie, O'Brien, Tom, Plise, Emile G., Shalan, Hadil, Sturino, Claudio, Wai, John, Xiao, Yang, Yin, Jianping, Zhao, Liang, Gould, Stephen, Olivero, Alan, Heffron, Timothy P.
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
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Journal Article
Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action
René, Olivier, Fauber, Benjamin P, Boenig, Gladys de Leon, Burton, Brenda, Eidenschenk, Céline, Everett, Christine, Gobbi, Alberto, Hymowitz, Sarah G, Johnson, Adam R, Kiefer, James R, Liimatta, Marya, Lockey, Peter, Norman, Maxine, Ouyang, Wenjun, Wallweber, Heidi A, Wong, Harvey
Published in ACS medicinal chemistry letters (12.03.2015)
Published in ACS medicinal chemistry letters (12.03.2015)
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Journal Article
Novel Antibody Interfaces Revealed Through Structural Mining
Yin, Yizhou, Romei, Matthew, Kannan Sankar, Pal, Lipika R, Kam Hon Hoi, Yang, Yanli, Brandon, Leonard, Gladys De Leon Boenig, Kumar, Nikit, Matsumoto, Marissa, Payandeh, Jian, Harris, Seth F, Moult, John, Lazar, Greg A
Published in bioRxiv (11.04.2022)
Published in bioRxiv (11.04.2022)
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Paper
Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members
Yang, Yanli, Yeh, Sherry H., Madireddi, Shravan, Matochko, Wadim L., Gu, Chen, Pacheco Sanchez, Patricia, Ultsch, Mark, De Leon Boenig, Gladys, Harris, Seth F., Leonard, Brandon, Scales, Suzie J., Zhu, Jing W., Christensen, Erin, Hang, Julie Q., Brezski, Randall J., Marsters, Scot, Ashkenazi, Avi, Sukumaran, Siddharth, Chiu, Henry, Cubas, Rafael, Kim, Jeong M., Lazar, Greg A.
Published in mAbs (18.08.2019)
Published in mAbs (18.08.2019)
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