BMS-345541 Is a Highly Selective Inhibitor of IκB Kinase That Binds at an Allosteric Site of the Enzyme and Blocks NF-κB-dependent Transcription in Mice
Burke, James R., Pattoli, Mark A., Gregor, Kurt R., Brassil, Patrick J., MacMaster, John F., McIntyre, Kim W., Yang, Xiaoxia, Iotzova, Violetta S., Clarke, Wendy, Strnad, Joann, Qiu, Yuping, Zusi, F. Christopher
Published in The Journal of biological chemistry (17.01.2003)
Published in The Journal of biological chemistry (17.01.2003)
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Journal Article
Design and Synthesis of a New Series of 4‑Heteroarylamino-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octanes as α7 Nicotinic Receptor Agonists. 1. Development of Pharmacophore and Early Structure–Activity Relationship
Cook, James, Zusi, F. Christopher, McDonald, Ivar M, King, Dalton, Hill, Matthew D, Iwuagwu, Christiana, Mate, Robert A, Fang, Haiquan, Zhao, Rulin, Wang, Bei, Cutrone, Jingfang, Ma, Baoqing, Gao, Qi, Knox, Ronald J, Matchett, Michele, Gallagher, Lizbeth, Ferrante, Meredith, Post-Munson, Debra, Molski, Thaddeus, Easton, Amy, Miller, Regina, Jones, Kelli, Digavalli, Siva, Healy, Francine, Lentz, Kimberley, Benitex, Yulia, Clarke, Wendy, Natale, Joanne, Siuciak, Judith A, Lodge, Nicholas, Zaczek, Robert, Denton, Rex, Morgan, Daniel, Bristow, Linda J, Macor, John E, Olson, Richard E
Published in Journal of medicinal chemistry (22.12.2016)
Published in Journal of medicinal chemistry (22.12.2016)
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Journal Article
Design and synthesis of a novel series of (1′S,2R,4′S)-3H-4′-azaspiro[benzo[4,5]imidazo[2,1-b]oxazole-2,2′-bicyclo[2.2.2]octanes] with high affinity for the α7 neuronal nicotinic receptor
Cook, James, Zusi, F. Christopher, Hill, Matthew D., Fang, Haiquan, Pearce, Bradley, Park, Hyunsoo, Gallagher, Lizbeth, McDonald, Ivar M., Bristow, Linda, Macor, John E., Olson, Richard E.
Published in Bioorganic & medicinal chemistry letters (15.11.2017)
Published in Bioorganic & medicinal chemistry letters (15.11.2017)
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Journal Article
Design and synthesis of a novel series of 4-heteroarylamino-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octanes as α7 nicotinic receptor agonists 2. Development of 4-heteroaryl SAR
Iwuagwu, Christiana, King, Dalton, McDonald, Ivar M., Cook, James, Zusi, F. Christopher, Hill, Matthew D., Mate, Robert A., Fang, Haiquan, Knox, Ronald, Gallagher, Lizbeth, Post-Munson Amy Easton, Debra, Miller, Regina, Benitex, Yulia, Siuciak, Judy, Lodge, Nicholas, Zaczek, Robert, Morgan, Daniel, Bristow, Linda, Macor, John E., Olson, Richard E.
Published in Bioorganic & medicinal chemistry letters (01.03.2017)
Published in Bioorganic & medicinal chemistry letters (01.03.2017)
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Journal Article
Triazolopyridine ethers as potent, orally active mGlu2 positive allosteric modulators for treating schizophrenia
Higgins, Mendi A., Marcin, Lawrence R., Christopher Zusi, F., Gentles, Robert, Ding, Min, Pearce, Bradley C., Easton, Amy, Kostich, Walter A., Seager, Matthew A., Bourin, Clotilde, Bristow, Linda J., Johnson, Kim A., Miller, Regina, Hogan, John, Whiterock, Valerie, Gulianello, Michael, Ferrante, Meredith, Huang, Yanling, Hendricson, Adam, Alt, Andrew, Macor, John E., Bronson, Joanne J.
Published in Bioorganic & medicinal chemistry (15.01.2017)
Published in Bioorganic & medicinal chemistry (15.01.2017)
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Journal Article
Development of 4‑Heteroarylamino-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octanes] as α7 Nicotinic Receptor Agonists
Hill, Matthew D, Fang, Haiquan, King, H. Dalton, Iwuagwu, Christiana I, McDonald, Ivar M, Cook, James, Zusi, F. Christopher, Mate, Robert A, Knox, Ronald J, Post-Munson, Debra, Easton, Amy, Miller, Regina, Lentz, Kimberley, Clarke, Wendy, Benitex, Yulia, Lodge, Nicholas, Zaczek, Robert, Denton, Rex, Morgan, Daniel, Bristow, Linda, Macor, John E, Olson, Richard
Published in ACS medicinal chemistry letters (12.01.2017)
Published in ACS medicinal chemistry letters (12.01.2017)
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Journal Article
BMS-933043, a Selective α7 nAChR Partial Agonist for the Treatment of Cognitive Deficits Associated with Schizophrenia
King, Dalton, Iwuagwu, Christiana, Cook, Jim, McDonald, Ivar M, Mate, Robert, Zusi, F. Christopher, Hill, Matthew D, Fang, Haiquan, Zhao, Rulin, Wang, Bei, Easton, Amy E, Miller, Regina, Post-Munson, Debra, Knox, Ronald J, Gallagher, Lizbeth, Westphal, Ryan, Molski, Thaddeus, Fan, Jingsong, Clarke, Wendy, Benitex, Yulia, Lentz, Kimberley A, Denton, Rex, Morgan, Daniel, Zaczek, Robert, Lodge, Nicholas J, Bristow, Linda J, Macor, John E, Olson, Richard E
Published in ACS medicinal chemistry letters (09.03.2017)
Published in ACS medicinal chemistry letters (09.03.2017)
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Journal Article
Discovery of a novel series of quinolone α7 nicotinic acetylcholine receptor agonists
McDonald, Ivar M., Mate, Robert A., Zusi, F. Christopher, Huang, Hong, Post-Munson, Debra J., Ferrante, Meredith A., Gallagher, Lizbeth, Bertekap, Robert L., Knox, Ronald J., Robertson, Barbara J., Harden, David G., Morgan, Daniel G., Lodge, Nicholas J., Dworetzky, Steven I., Olson, Richard E., Macor, John E.
Published in Bioorganic & medicinal chemistry letters (15.03.2013)
Published in Bioorganic & medicinal chemistry letters (15.03.2013)
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Journal Article
Synthesis and biological evaluation of 4-amino derivatives of benzimidazoquinoxaline, benzimidazoquinoline, and benzopyrazoloquinazoline as potent IKK inhibitors
Beaulieu, Francis, Ouellet, Carl, Ruediger, Edward H., Belema, Makonen, Qiu, Yuping, Yang, Xuejie, Banville, Jacques, Burke, James R., Gregor, Kurt R., MacMaster, John F., Martel, Alain, McIntyre, Kim W., Pattoli, Mark A., Zusi, F. Christopher, Vyas, Dolatrai
Published in Bioorganic & medicinal chemistry letters (01.03.2007)
Published in Bioorganic & medicinal chemistry letters (01.03.2007)
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Journal Article
Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1
Marcin, Lawrence R., Higgins, Mendi A., Zusi, F. Christopher, Zhang, Yunhui, Dee, Michael F., Parker, Michael F., Muckelbauer, Jodi K., Camac, Daniel M., Morin, Paul E., Ramamurthy, Vidhyashankar, Tebben, Andrew J., Lentz, Kimberley A., Grace, James E., Marcinkeviciene, Jovita A., Kopcho, Lisa M., Burton, Catherine R., Barten, Donna M., Toyn, Jeremy H., Meredith, Jere E., Albright, Charles F., Bronson, Joanne J., Macor, John E., Thompson, Lorin A.
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Journal Article
Rational design of RAR-selective ligands revealed by RARβ crystal stucture
Germain, Pierre, Kammerer, Sabrina, Pérez, Efrén, Peluso-Iltis, Carole, Tortolani, David, Zusi, F Christopher, Starrett, John, Lapointe, Philippe, Daris, Jean-Paul, Marinier, Anne, de Lera, Angel R, Rochel, Natacha, Gronemeyer, Hinrich
Published in EMBO reports (01.09.2004)
Published in EMBO reports (01.09.2004)
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Journal Article
Progress in the discovery of BACE inhibitors
Thompson, Lorin A, Bronson, Joanne J, Zusi, F Christopher
Published in Current pharmaceutical design (01.01.2005)
Published in Current pharmaceutical design (01.01.2005)
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Journal Article
Selective retinoids and rexinoids in cancer therapy and chemoprevention
Zusi, F.Christopher, Lorenzi, Matthew V, Vivat-Hannah, Valerie
Published in Drug Discovery Today (01.12.2002)
Published in Drug Discovery Today (01.12.2002)
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Book Review
Journal Article
Retinoids as therapeutic agents: today and tomorrow
Vivat-Hannah, Valerie, Zusi, F Christopher
Published in Mini reviews in medicinal chemistry (01.08.2005)
Published in Mini reviews in medicinal chemistry (01.08.2005)
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Journal Article
Rational design of RAR-selective ligands revealed by RARbeta crystal stucture
Germain, Pierre, Kammerer, Sabrina, Pérez, Efrén, Peluso-Iltis, Carole, Tortolani, David, Zusi, F Christopher, Starrett, John, Lapointe, Philippe, Daris, Jean-Paul, Marinier, Anne, de Lera, Angel R, Rochel, Natacha, Gronemeyer, Hinrich
Published in EMBO reports (01.09.2004)
Published in EMBO reports (01.09.2004)
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Journal Article
Design and synthesis of a novel series of (1 ' S,2R,4 ' S)-3H-4 '-azaspiro [benzo[4,5] imidazo[2,1-b]oxazole-2,2 '-bicyclo[2.2.2]octanes] with high affinity for the alpha 7 neuronal nicotinic receptor
Cook, James, Zusi, F. Christopher, Hill, Matthew D., Fang, Haiquan, Pearce, Bradley, Park, Hyunsoo, Gallagher, Lizbeth, McDonald, Ivar M., Bristow, Linda, Macor, John E., Olson, Richard E.
Published in Bioorganic & medicinal chemistry letters (15.11.2017)
Published in Bioorganic & medicinal chemistry letters (15.11.2017)
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Journal Article
Design and synthesis of a novel series of (1′ S ,2 R ,4′ S )-3 H -4′-azaspiro[benzo[4,5]imidazo[2,1- b ]oxazole-2,2′-bicyclo[2.2.2]octanes] with high affinity for the α7 neuronal nicotinic receptor
Cook, James, Zusi, F. Christopher, Hill, Matthew D., Fang, Haiquan, Pearce, Bradley, Park, Hyunsoo, Gallagher, Lizbeth, McDonald, Ivar M., Bristow, Linda, Macor, John E., Olson, Richard E.
Published in Bioorganic & medicinal chemistry letters (01.11.2017)
Published in Bioorganic & medicinal chemistry letters (01.11.2017)
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Journal Article
QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS
KING DALTON, MCDONALD IVAR M, ZUSI F. CHRISTOPHER, COOK II JAMES H, IWUAGWU CHRISTIANA I, MACOR JOHN E, WANG NENGHUI, OLSON RICHARD E
Year of Publication 06.09.2012
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Year of Publication 06.09.2012
Patent
Competitive, Reversible Inhibition of Cytosolic Phospholipase A2 at the Lipid-Water Interface by Choline Derivatives That Partially Partition into the Phospholipid Bilayer
Burke, J R, Witmer, M R, Zusi, F C, Gregor, K R, Davern, L B, Padmanabha, R, Swann, R T, Smith, D, Tredup, J A, Micanovic, R, Manly, S P, Villafranca, J J, Tramposch, K M
Published in The Journal of biological chemistry (02.07.1999)
Published in The Journal of biological chemistry (02.07.1999)
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Journal Article