Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells
Ohigashi, Izumi, Zuklys, Saulius, Sakata, Mie, Mayer, Carlos E., Zhanybekova, Saule, Murata, Shigeo, Tanaka, Keiji, Holländer, Georg A., Takahama, Yousuke
Published in Proceedings of the National Academy of Sciences - PNAS (11.06.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (11.06.2013)
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Let-7 enhances murine anti-tumor CD8 T cell responses by promoting memory and antagonizing terminal differentiation
Wells, Alexandria C., Hioki, Kaito A., Angelou, Constance C., Lynch, Adam C., Liang, Xueting, Ryan, Daniel J., Thesmar, Iris, Zhanybekova, Saule, Zuklys, Saulius, Ullom, Jacob, Cheong, Agnes, Mager, Jesse, Hollander, Georg A., Pobezinskaya, Elena L., Pobezinsky, Leonid A.
Published in Nature communications (11.09.2023)
Published in Nature communications (11.09.2023)
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Combined multidimensional single-cell protein and RNA profiling dissects the cellular and functional heterogeneity of thymic epithelial cells
Klein, Fabian, Veiga-Villauriz, Clara, Börsch, Anastasiya, Maio, Stefano, Palmer, Sam, Dhalla, Fatima, Handel, Adam E., Zuklys, Saulius, Calvo-Asensio, Irene, Musette, Lucas, Deadman, Mary E., White, Andrea J., Lucas, Beth, Anderson, Graham, Holländer, Georg A.
Published in Nature communications (10.07.2023)
Published in Nature communications (10.07.2023)
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Journal Article
Abrogation of Notch Signaling in Embryonic TECs Impacts Postnatal mTEC Homeostasis and Thymic Involution
García-León, María Jesús, Mosquera, Marta, Cela, Carmela, Alcain, Juan, Zuklys, Saulius, Holländer, Georg, Toribio, María L
Published in Frontiers in immunology (30.05.2022)
Published in Frontiers in immunology (30.05.2022)
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Journal Article
Adult Thymic Medullary Epithelium Is Maintained and Regenerated by Lineage-Restricted Cells Rather Than Bipotent Progenitors
Ohigashi, Izumi, Zuklys, Saulius, Sakata, Mie, Mayer, Carlos E., Hamazaki, Yoko, Minato, Nagahiro, Hollander, Georg A., Takahama, Yousuke
Published in Cell reports (Cambridge) (17.11.2015)
Published in Cell reports (Cambridge) (17.11.2015)
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Journal Article
IL-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCRγδ+ intraepithelial lymphocytes
Shitara, Soichiro, Hara, Takahiro, Liang, Bingfei, Wagatsuma, Keisuke, Zuklys, Saulius, Holländer, Georg A, Nakase, Hiroshi, Chiba, Tsutomu, Tani-ichi, Shizue, Ikuta, Koichi
Published in The Journal of immunology (1950) (15.06.2013)
Published in The Journal of immunology (1950) (15.06.2013)
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Comprehensively Profiling the Chromatin Architecture of Tissue Restricted Antigen Expression in Thymic Epithelial Cells Over Development
Handel, Adam E, Shikama-Dorn, Noriko, Zhanybekova, Saule, Maio, Stefano, Graedel, Annina N, Zuklys, Saulius, Ponting, Chris P, Holländer, Georg A
Published in Frontiers in immunology (19.09.2018)
Published in Frontiers in immunology (19.09.2018)
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Journal Article
TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development
Jenkinson, S. Rhiannon, Williams, Joy A., Jeon, Hyein, Zhang, Jingjing, Nitta, Takeshi, Ohigashi, Izumi, Kruhlak, Michael, Zuklys, Saulius, Sharrow, Susan, Adams, Anthony, Granger, Larry, Choi, Yongwon, Siebenlist, Ulrich, Bishop, Gail A., Hollander, Georg A., Takahama, Yousuke, Hodes, Richard J.
Published in Proceedings of the National Academy of Sciences - PNAS (24.12.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (24.12.2013)
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Journal Article
Cellular and molecular events during early thymus development
Holländer, Georg, Gill, Jason, Zuklys, Saulius, Iwanami, Norimasa, Liu, Cunlan, Takahama, Yousuke
Published in Immunological reviews (01.02.2006)
Published in Immunological reviews (01.02.2006)
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Journal Article
Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2
Barthlott, Thomas, Handel, Adam E., Teh, Hong Ying, Wirasinha, Rushika C., Hafen, Katrin, Žuklys, Saulius, Roch, Benoit, Orkin, Stuart H., de Villartay, Jean-Pierre, Daley, Stephen R., Holländer, Georg A.
Published in Nature communications (24.06.2021)
Published in Nature communications (24.06.2021)
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Journal Article
Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells
Žuklys, Saulius, Handel, Adam, Zhanybekova, Saule, Govani, Fatima, Keller, Marcel, Maio, Stefano, Mayer, Carlos E, Teh, Hong Ying, Hafen, Katrin, Gallone, Giuseppe, Barthlott, Thomas, Ponting, Chris P, Holländer, Georg A
Published in Nature immunology (01.10.2016)
Published in Nature immunology (01.10.2016)
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Journal Article
Monoallelic Expression of the Interleukin-2 Locus
Holländer, Georg A., Zuklys, Saulius, Morel, Corinne, Mizoguchi, Emiko, Mobisson, Kathrine, Simpson, Stephen, Terhorst, Cox, Wishart, William, Golan, David E., Bhan, Atul K., Burakoff, Steven J.
Published in Science (American Association for the Advancement of Science) (27.03.1998)
Published in Science (American Association for the Advancement of Science) (27.03.1998)
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Journal Article
IL-2 and IL-15 drive intrathymic development of distinct periphery-seeding CD4+Foxp3+ regulatory T lymphocytes
Apert, Cécile, Galindo-Albarrán, Ariel O., Castan, Sarah, Detraves, Claire, Michaud, Héloise, McJannett, Nicola, Haegeman, Bart, Fillatreau, Simon, Malissen, Bernard, Holländer, Georg, Žuklys, Saulius, Santamaria, Jérémy C., Joffre, Olivier P., Romagnoli, Paola, van Meerwijk, Joost P. M.
Published in Frontiers in immunology (08.09.2022)
Published in Frontiers in immunology (08.09.2022)
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Journal Article
Delta-like 4 is indispensable in thymic environment specific for T cell development
Hozumi, Katsuto, Mailhos, Carolina, Negishi, Naoko, Hirano, Ken-ichi, Yahata, Takashi, Ando, Kiyoshi, Zuklys, Saulius, Holländer, Georg A, Shima, David T, Habu, Sonoko
Published in The Journal of experimental medicine (27.10.2008)
Published in The Journal of experimental medicine (27.10.2008)
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Journal Article
A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla
Hauri-Hohl, Mathias, Zuklys, Saulius, Holländer, Georg A, Ziegler, Steven F
Published in Nature immunology (01.06.2014)
Published in Nature immunology (01.06.2014)
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Journal Article
IL-7 Produced by Thymic Epithelial Cells Plays a Major Role in the Development of Thymocytes and TCR gamma delta + Intraepithelial Lymphocytes
Shitara, Soichiro, Hara, Takahiro, Liang, Bingfei, Wagatsuma, Keisuke, Zuklys, Saulius, Hollaender, Georg A, Nakase, Hiroshi, Chiba, Tsutomu, Tani-ichi, Shizue, Ikuta, Koichi
Published in The Journal of immunology (1950) (15.06.2013)
Published in The Journal of immunology (1950) (15.06.2013)
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Journal Article
The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor
Papadopoulou, Aikaterini S, Dooley, James, Linterman, Michelle A, Pierson, Wim, Ucar, Olga, Kyewski, Bruno, Zuklys, Saulius, Hollander, Georg A, Matthys, Patrick, Gray, Daniel H D, De Strooper, Bart, Liston, Adrian
Published in Nature immunology (01.02.2012)
Published in Nature immunology (01.02.2012)
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Journal Article
Dynamic spatio-temporal contribution of single beta 5t+ cortical epithelial precursors to the thymus medulla
Mayer, Carlos E, uklys, Saulius, Zhanybekova, Saule, Ohigashi, Izumi, Teh, Hong-Ying, Sansom, Stephen N, Shikama-Dorn, Noriko, Hafen, Katrin, Macaulay, Iain C, Deadman, Mary E, Ponting, Chris P, Takahama, Yousuke, Hollaender, Georg A
Published in European journal of immunology (01.04.2016)
Published in European journal of immunology (01.04.2016)
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Journal Article
Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice
Holländer, Georg A, Balciunaite, Gina, Keller, Marcel P, Balciunaite, Egle, Piali, Luca, Zuklys, Saulius, Mathieu, Yves D, Gill, Jason, Boyd, Richard, Sussman, Daniel J
Published in Nature immunology (01.11.2002)
Published in Nature immunology (01.11.2002)
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Journal Article
Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells
Rossi, Simona W., Jeker, Lukas T., Ueno, Tomoo, Kuse, Sachiyo, Keller, Marcel P., Zuklys, Saulius, Gudkov, Andrei V., Takahama, Yousuke, Krenger, Werner, Blazar, Bruce R., Holländer, Georg A.
Published in Blood (01.05.2007)
Published in Blood (01.05.2007)
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