Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling
Ding, Xinxin, Hough, Lindsay B, Conroy, Jennie L, Fang, Cheng, Gu, Jun, Zeitlin, Scott O, Yang, Weizhu, Yang, Jun, VanAlstine, Melissa A, Nalwalk, Julia W, Albrecht, Phillip J, Mazurkiewicz, Joseph E, Snyder-Keller, Abigail, Shan, Zhixing, Zhang, Shao-Zhong, Wentland, Mark P, Behr, Melissa, Knapp, Brian I, Bidlack, Jean M, Zuiderveld, Obbe P, Leurs, Rob
Published in Nature neuroscience (01.03.2010)
Published in Nature neuroscience (01.03.2010)
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N-substituted piperidinyl alkyl imidazoles: Discovery of methimepip as a potent and selective histamine H-3 receptor agonist
Kitbunnadaj, R, Hashimoto, T, Poli, E, Zuiderveld, OP, Menozzi, A, Hidaka, R, de Esch, IJP, Bakker, RA, Menge, WMPB, Yamatodani, A, Coruzzi, G, Timmerman, H, Leurs, R
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
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Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H-3 receptor agonist
Kitbunnadaj, R, Zuiderveld, OP, Christophe, B, Hulscher, S, Menge, WMPB, Gelens, E, Snip, E, Bakker, RA, Celanire, S, Gillard, M, Talaga, P, Timmerman, H, Leurs, R
Published in Journal of medicinal chemistry (06.05.2004)
Published in Journal of medicinal chemistry (06.05.2004)
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A selective human H-4-receptor agonist: (-)-2-cyano-1-methyl-3-{(2R,5R)-5-[1H-imidazol-4(5)-yl]tetrahydrofuran-2-yl}methylguanidine
Hashimoto, T, Harusawa, S, Araki, L, Zuiderveld, OP, Smit, MJ, Imazu, T, Takashima, S, Yamamoto, Y, Sakamoto, Y, Kurihara, T, Leurs, R, Bakker, RA, Yamatodani, A
Published in Journal of medicinal chemistry (03.07.2003)
Published in Journal of medicinal chemistry (03.07.2003)
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Journal Article
Synthesis and structure-activity relationships of conformationally constrained histamine H-3 receptor agonists
Kitbunnadaj, R, Zuiderveld, OP, De Esch, IJP, Vollinga, RC, Bakker, R, Lutz, M, Spek, AL, Cavoy, E, Deltent, MF, Menge, WMPB, Timmerman, H, Leurs, R
Published in Journal of medicinal chemistry (04.12.2003)
Published in Journal of medicinal chemistry (04.12.2003)
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Journal Article
Non-imidazole histamine H-3 ligands, part 2: New 2-substituted benzothiazoles as histamine H-3 antagonists
Walczynski, K, Guryn, R, Zuiderveld, OP, Timmerman, H
Published in Archiv der Pharmazie (Weinheim) (01.11.1999)
Published in Archiv der Pharmazie (Weinheim) (01.11.1999)
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8R-Lisuride Is a Potent Stereospecific Histamine H1-Receptor Partial Agonist
Bakker, R A, Weiner, D M, ter Laak, T, Beuming, T, Zuiderveld, O P, Edelbroek, M, Hacksell, U, Timmerman, H, Brann, M R, Leurs, R
Published in Molecular pharmacology (01.03.2004)
Published in Molecular pharmacology (01.03.2004)
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Journal Article
Characterization of the binding site of the histamine H-3 receptor. 1. Various approaches to the synthesis of 2-(1H-imidazol-4-yl)cyclopropylamine and histaminergic activity of (1R,2R)- and (1S,2S)-2-(1H-imidazol-4-yl)cyclopropylamine
De Esch, IJP, Vollinga, RC, Goubitz, K, Schenk, H, Appelberg, U, Hacksell, U, Lemstra, S, Zuiderveld, OP, Hoffmann, M, Leurs, R, Menge, WMPB, Timmerman, H
Published in Journal of medicinal chemistry (08.04.1999)
Published in Journal of medicinal chemistry (08.04.1999)
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Journal Article
Pharmacological characterisation of the histamine H 3 receptor in the rat hippocampus
Alves-Rodrigues, Alexandra, Timmerman, Henk, Willems, Edwin, Lemstra, Sylvia, Zuiderveld, Obbe P, Leurs, Rob
Published in Brain research (30.03.1998)
Published in Brain research (30.03.1998)
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Journal Article
Synthesis and pharmacological evaluation of some amino-acid-containing cyproheptadine derivatives as dual antagonists of histamine H 1- and leukotriene D 4-receptors
Zhang, MQ, van de Stolpe, A, Zuiderveld, OP, Timmerman, H
Published in European journal of medicinal chemistry (1997)
Published in European journal of medicinal chemistry (1997)
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Journal Article
Synthesis and pharmacological evaluation of some amino-acid-containing cyproheptadine derivatives as dual antagonists of histamine H1- and leukotriene D4-receptors
Zhang, MQ, van de Stolpe, A, Zuiderveld, OP, Timmerman, H
Published in European journal of medicinal chemistry (01.01.1997)
Published in European journal of medicinal chemistry (01.01.1997)
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Histamine H 1 receptor ligands : Part II. Synthesis and in vitro pharmacology of 2-[2-(phenylamino)thiazol-4-yl]ethanamine and 2-(2-benzhydrylthiazol-4-yl)ethanamine derivatives
Walczyński, Krzysztof, Guryn, Roman, Zuiderveld, Obbe P, Zhang, Ming-Qiang, Timmerman, Henk
Published in Farmaco (Società chimica italiana : 1989) (01.09.2000)
Published in Farmaco (Società chimica italiana : 1989) (01.09.2000)
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Screening of cattle urine samples for the presence of beta-agonists with a functional test : some preliminary results
SCHILT, R, HOOIJERINK, H, HUF, F. A, ZUIDERVELD, O. P, BAST, A
Published in Analyst (London) (01.12.1994)
Published in Analyst (London) (01.12.1994)
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