Structure of the Bacterial Deacetylase LpxC Bound to the Nucleotide Reaction Product Reveals Mechanisms of Oxyanion Stabilization and Proton Transfer
Clayton, Gina M., Klein, Daniel J., Rickert, Keith W., Patel, Sangita B., Kornienko, Maria, Zugay-Murphy, Joan, Reid, John C., Tummala, Srivanya, Sharma, Sujata, Singh, Sheo B., Miesel, Lynn, Lumb, Kevin J., Soisson, Stephen M.
Published in The Journal of biological chemistry (22.11.2013)
Published in The Journal of biological chemistry (22.11.2013)
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Structural Basis of Human p70 Ribosomal S6 Kinase-1 Regulation by Activation Loop Phosphorylation
Sunami, Tomoko, Byrne, Noel, Diehl, Ronald E., Funabashi, Kaoru, Hall, Dawn L., Ikuta, Mari, Patel, Sangita B., Shipman, Jennifer M., Smith, Robert F., Takahashi, Ikuko, Zugay-Murphy, Joan, Iwasawa, Yoshikazu, Lumb, Kevin J., Munshi, Sanjeev K., Sharma, Sujata
Published in The Journal of biological chemistry (12.02.2010)
Published in The Journal of biological chemistry (12.02.2010)
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L-735,524: The Design of a Potent and Orally Bioavailable HIV Protease Inhibitor
Dorsey, Bruce D, Levin, Rhonda B, McDaniel, Stacy L, Vacca, Joseph P, Guare, James P, Darke, Paul L, Zugay, Joan A, Emini, Emilio A, Schleif, William A
Published in Journal of medicinal chemistry (01.10.1994)
Published in Journal of medicinal chemistry (01.10.1994)
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Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors
Huang, Shaei, Garbaccio, Robert M., Fraley, Mark E., Steen, Justin, Kreatsoulas, Constantine, Hartman, George, Stirdivant, Steve, Drakas, Bob, Rickert, Keith, Walsh, Eileen, Hamilton, Kelly, Buser, Carolyn A., Hardwick, James, Mao, Xianzhi, Abrams, Marc, Beck, Steve, Tao, Weikang, Lobell, Rob, Sepp-Lorenzino, Laura, Yan, Youwei, Ikuta, Mari, Murphy, Joan Zugay, Sardana, Vinod, Munshi, Sanjeev, Kuo, Lawrence, Reilly, Michael, Mahan, Elizabeth
Published in Bioorganic & medicinal chemistry letters (15.11.2006)
Published in Bioorganic & medicinal chemistry letters (15.11.2006)
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Identification of MK-944a: A Second Clinical Candidate from the Hydroxylaminepentanamide Isostere Series of HIV Protease Inhibitors
Dorsey, Bruce D, McDonough, Colleen, McDaniel, Stacey L, Levin, Rhonda B, Newton, Christina L, Hoffman, Jacob M, Darke, Paul L, Zugay-Murphy, Joan A, Emini, Emilio A, Schleif, William A, Olsen, David B, Stahlhut, Mark W, Rutkowski, Carrie A, Kuo, Lawrence C, Lin, Jiunn H, Chen, I-W, Michelson, Stuart R, Holloway, M. Katharine, Huff, Joel R, Vacca, Joseph P
Published in Journal of medicinal chemistry (07.09.2000)
Published in Journal of medicinal chemistry (07.09.2000)
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Dissociation and association of the HIV-1 protease dimer subunits: Equilibria and rates
Darke, Paul L, Hall, Dawn L, Jordan, Susan P, Zugay, Joan A, Shafer, Jules A, Kuo, Lawrence C
Published in Biochemistry (Easton) (11.01.1994)
Published in Biochemistry (Easton) (11.01.1994)
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Only a Small Fraction of Purified Hepatitis C RNA-Dependent RNA Polymerase Is Catalytically Competent: Implications for Viral Replication and in Vitro Assays
Carroll, Steven S, Sardana, Vinod, Yang, Zhucheng, Jacobs, Amanda R, Mizenko, Christine, Hall, Dawn, Hill, Lorraine, Zugay-Murphy, Joan, Kuo, Lawrence C
Published in Biochemistry (Easton) (18.07.2000)
Published in Biochemistry (Easton) (18.07.2000)
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3-Tetrahydrofuran and pyran urethanes as high-affinity P2-ligands for HIV-1 protease inhibitors
Ghosh, Arun K, Thompson, Wayne J, McKee, Sean P, Duong, Tien T, Lyle, Terry A, Chen, Jenny C, Darke, Paul L, Zugay, Joan A, Emini, Emilio A
Published in Journal of medicinal chemistry (1993)
Published in Journal of medicinal chemistry (1993)
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Potent HIV protease inhibitors: the development of tetrahydrofuranylglycines as novel P2-ligands and pyrazine amides as P3-ligands
Ghosh, Arun K, Thompson, Wayne J, Holloway, M. Katharine, McKee, Sean P, Duong, Tien T, Lee, Hee Yoon, Munson, Peter M, Smith, Anthony M, Wai, Jenny M, Darke, Paul L, Zugay, Joan A, Emini, Emilio A, Schleif, William A, Huff, Joel R, Anderson, Paul S
Published in Journal of medicinal chemistry (01.08.1993)
Published in Journal of medicinal chemistry (01.08.1993)
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Potent HIV-1 protease inhibitors: stereoselective synthesis of a dipeptide mimic
Ghosh, Arun K, McKee, Sean P, Thompson, Wayne J, Darke, Paul L, Zugay, Joan C
Published in Journal of organic chemistry (01.02.1993)
Published in Journal of organic chemistry (01.02.1993)
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A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: synthesis, enzyme inhibition, and antiviral activity
Tucker, Thomas J, Lumma, William C, Payne, Linda S, Wai, Jenny M, De Solms, S. Jane, Giuliani, Elizabeth A, Darke, Paul L, Heimbach, Jill C, Zugay, Joan A
Published in Journal of medicinal chemistry (01.07.1992)
Published in Journal of medicinal chemistry (01.07.1992)
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Benzocycloalkyl amines as novel C-termini for HIV protease inhibitors
Lyle, Terry A, Wiscount, Catherine M, Guare, James P, Thompson, Wayne J, Anderson, Paul S, Darke, Paul L, Zugay, Joan A, Emini, Emilio A, Schleif, William A
Published in Journal of medicinal chemistry (01.03.1991)
Published in Journal of medicinal chemistry (01.03.1991)
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Nonpeptidal P2 Ligands for HIV Protease Inhibitors: Structure-Based Design, Synthesis, and Biological Evaluation
Ghosh, Arun K, Kincaid, John F, Walters, D. Eric, Chen, Yan, Chaudhuri, Narayan C, Thompson, Wayne J, Culberson, Chris, Fitzgerald, Paula M. D, Lee, Hee Yoon, McKee, Sean P, Munson, Peter M, Duong, Tien T, Darke, Paul L, Zugay, Joan A, Schleif, William A, Axel, Melinda G, Lin, Juinn, Huff, Joel R
Published in Journal of medicinal chemistry (16.08.1996)
Published in Journal of medicinal chemistry (16.08.1996)
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Cyclic sulfolanes as novel and high-affinity P2 ligands for HIV-1 protease inhibitors
Ghosh, Arun K, Thompson, Wayne J, Lee, Hee Yoon, McKee, Sean P, Munson, Peter M, Duong, Tien T, Darke, Paul L, Zugay, Joan A, Emini, Emilio A
Published in Journal of medicinal chemistry (01.04.1993)
Published in Journal of medicinal chemistry (01.04.1993)
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An Uniquely Purified HCV NS3 Protease and NS4A21–34 Peptide Form a Highly Active Serine Protease Complex in Peptide Hydrolysis
Sardana, Vinod.V., Blue, Jeffrey T., Zugay-Murphy, Joan, Sardana, Mohinder K., Kuo, Lawrence C.
Published in Protein expression and purification (01.08.1999)
Published in Protein expression and purification (01.08.1999)
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A Priori Prediction of Activity for HIV-1 Protease Inhibitors Employing Energy Minimization in the Active Site
Holloway, M. Katharine, Wai, Jenny M, Halgren, Thomas A, Fitzgerald, Paula M. D, Vacca, Joseph P, Dorsey, Bruce D, Levin, Rhonda B, Thompson, Wayne J, Chen, L. Jenny, deSolms, S. Jane, Gaffin, Neil, Ghosh, Arun K, Giuliani, Elizabeth A, Graham, Samuel L, Guare, James P, Hungate, Randall W, Lyle, Terry A, Sanders, William M, Tucker, Thomas J, Wiggins, Mark, Wiscount, Catherine M, Woltersdorf, Otto W, Young, Steven D, Darke, Paul L, Zugay, Joan A
Published in Journal of medicinal chemistry (24.05.1996)
Published in Journal of medicinal chemistry (24.05.1996)
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Synthesis and antiviral activity of a series of HIV-1 protease inhibitors with functionality tethered to the P1 or P1' phenyl design
Thompson, Wayne J, Fitzgerald, Paula M. D, Holloway, M. Katharine, Emini, Emilio A, Darke, Paul L, McKeever, Brian M, Schleif, William A, Quintero, Julio C, Zugay, Joan A
Published in Journal of medicinal chemistry (01.05.1992)
Published in Journal of medicinal chemistry (01.05.1992)
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Discovery of 1-Amino-5H-pyrido[4,3-b]indol-4-carboxamide Inhibitors of Janus Kinase 2 (JAK2) for the Treatment of Myeloproliferative Disorders
Lim, Jongwon, Taoka, Brandon, Otte, Ryan D, Spencer, Kerrie, Dinsmore, Christopher J, Altman, Michael D, Chan, Grace, Rosenstein, Craig, Sharma, Sujata, Su, Hua-Poo, Szewczak, Alexander A, Xu, Lin, Yin, Hong, Zugay-Murphy, Joan, Marshall, C. Gary, Young, Jonathan R
Published in Journal of medicinal chemistry (27.10.2011)
Published in Journal of medicinal chemistry (27.10.2011)
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Discovery of 1-Amino-5 H -pyrido[4,3- b ]indol-4-carboxamide Inhibitors of Janus Kinase 2 (JAK2) for the Treatment of Myeloproliferative Disorders
Lim, Jongwon, Taoka, Brandon, Otte, Ryan D., Spencer, Kerrie, Dinsmore, Christopher J., Altman, Michael D., Chan, Grace, Rosenstein, Craig, Sharma, Sujata, Su, Hua-Poo, Szewczak, Alexander A., Xu, Lin, Yin, Hong, Zugay-Murphy, Joan, Marshall, C. Gary, Young, Jonathan R.
Published in Journal of medicinal chemistry (27.10.2011)
Published in Journal of medicinal chemistry (27.10.2011)
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Journal Article
A priori prediction of activity for HIV-1 protease inhibitors employing energy minimization in the active site
Holloway, M. Katharine, Wai, Jenny M, Halgren, Thomas A, Fitzgerald, Paula M. D, Vacca, Joseph P, Dorsey, Bruce D, Levin, Rhonda B, Thompson, Wayne J, Chen, L. Jenny
Published in Journal of medicinal chemistry (01.01.1995)
Published in Journal of medicinal chemistry (01.01.1995)
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