Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer
Mercurio, Ciro, dal Zuffo, Roberto, Liontos, Michalis, d'Ario, Giovanni, Hahn, William C, Gorgoulis, Vassilis, Dobreva, Miryana, Minucci, Saverio, Sulli, Gabriele, Montani, Erica, d'Adda di Fagagna, Fabrizio, Matti, Valentina, Gargiulo, Gaetano, Di Micco, Raffaella, Botrugno, Oronza A
Published in Nature cell biology (01.03.2011)
Published in Nature cell biology (01.03.2011)
Get full text
Journal Article
Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner
Elgendy, Mohamed, Ciro, Marco, Abdel-Aziz, Amal Kamal, Belmonte, Giuseppe, Dal Zuffo, Roberto, Mercurio, Ciro, Miracco, Clelia, Lanfrancone, Luisa, Foiani, Marco, Minucci, Saverio
Published in Nature communications (04.12.2014)
Published in Nature communications (04.12.2014)
Get full text
Journal Article
Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation
Ravasio, Roberto, Ceccacci, Elena, Nicosia, Luciano, Hosseini, Amir, Rossi, Pier Luigi, Barozzi, Iros, Fornasari, Lorenzo, Zuffo, Roberto Dal, Valente, Sergio, Fioravanti, Rossella, Mercurio, Ciro, Varasi, Mario, Mattevi, Andrea, Mai, Antonello, Pavesi, Giulio, Bonaldi, Tiziana, Minucci, Saverio
Published in Science advances (01.04.2020)
Published in Science advances (01.04.2020)
Get full text
Journal Article
Pathology tissue—chromatin immunoprecipitation, coupled with high-throughput sequencing, allows the epigenetic profiling of patient samples
Fanelli, Micro, Amatori, Stefano, Barozzi, Iros, Soncini, Matias, Zuffo, Roberto Dal, Bucci, Gabriele, Capra, Maria, Quarto, Micaela, Dellino, Gaetano Ivan, Mercurio, Ciro, Alcalay, Myriam, Viale, Giuseppe, Pelicci, Pier Giuseppe, Minucci, Saverio, Dawid, Igor B.
Published in Proceedings of the National Academy of Sciences - PNAS (14.12.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (14.12.2010)
Get full text
Journal Article
Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent
Vianello, Paola, Botrugno, Oronza A, Cappa, Anna, Dal Zuffo, Roberto, Dessanti, Paola, Mai, Antonello, Marrocco, Biagina, Mattevi, Andrea, Meroni, Giuseppe, Minucci, Saverio, Stazi, Giulia, Thaler, Florian, Trifiró, Paolo, Valente, Sergio, Villa, Manuela, Varasi, Mario, Mercurio, Ciro
Published in Journal of medicinal chemistry (25.02.2016)
Published in Journal of medicinal chemistry (25.02.2016)
Get full text
Journal Article
Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models
Romussi, Alessia, Cappa, Anna, Vianello, Paola, Brambillasca, Silvia, Cera, Maria Rosaria, Dal Zuffo, Roberto, Fagà, Giovanni, Fattori, Raimondo, Moretti, Loris, Trifirò, Paolo, Villa, Manuela, Vultaggio, Stefania, Cecatiello, Valentina, Pasqualato, Sebastiano, Dondio, Giulio, So, Chi Wai Eric, Minucci, Saverio, Sartori, Luca, Varasi, Mario, Mercurio, Ciro
Published in ACS medicinal chemistry letters (14.05.2020)
Published in ACS medicinal chemistry letters (14.05.2020)
Get full text
Journal Article
Synthesis and biological characterization of spiro[2H-(1,3)-benzoxazine-2,4′-piperidine] based histone deacetylase inhibitors
Thaler, Florian, Varasi, Mario, Abate, Agnese, Carenzi, Giacomo, Colombo, Andrea, Bigogno, Chiara, Boggio, Roberto, Zuffo, Roberto Dal, Rapetti, Daniela, Resconi, Anna, Regalia, Nickolas, Vultaggio, Stefania, Dondio, Giulio, Gagliardi, Stefania, Minucci, Saverio, Mercurio, Ciro
Published in European journal of medicinal chemistry (01.06.2013)
Published in European journal of medicinal chemistry (01.06.2013)
Get full text
Journal Article
Novel potent inhibitors of the histone demethylase KDM1A (LSD1), orally active in a murine promyelocitic leukemia model
Trifirò, Paolo, Cappa, Anna, Brambillasca, Silvia, Botrugno, Oronza A, Cera, Maria Rosaria, Zuffo, Roberto Dal, Dessanti, Paola, Meroni, Giuseppe, Thaler, Florian, Villa, Manuela, Minucci, Saverio, Mercurio, Ciro, Varasi, Mario, Vianello, Paola
Published in Future medicinal chemistry (01.07.2017)
Published in Future medicinal chemistry (01.07.2017)
Get full text
Journal Article
Chiral Resolution and Pharmacological Characterization of the Enantiomers of the Hsp90 Inhibitor 2-Amino-7-[4-fluoro-2-(3-pyridyl)phenyl]-4-methyl-7,8-dihydro-6H-quinazolin-5-one Oxime
Amici, Raffaella, Bigogno, Chiara, Boggio, Roberto, Colombo, Andrea, Courtney, Stephen M., Dal Zuffo, Roberto, Dondio, Giulio, Fusar, Fulvia, Gagliardi, Stefania, Minucci, Saverio, Molteni, Marco, Montalbetti, Christian A. G. N., Mortoni, Annalisa, Varasi, Mario, Vultaggio, Stefania, Mercurio, Ciro
Published in ChemMedChem (01.07.2014)
Published in ChemMedChem (01.07.2014)
Get full text
Journal Article
Spiro[chromane-2,4′-piperidine]-Based Histone Deacetylase Inhibitors with Improved in vivo Activity
Thaler, Florian, Varasi, Mario, Carenzi, Giacomo, Colombo, Andrea, Abate, Agnese, Bigogno, Chiara, Boggio, Roberto, Carrara, Simone, Cataudella, Tiziana, Dal Zuffo, Roberto, Reali, Veronica, Vultaggio, Stefania, Dondio, Giulio, Gagliardi, Stefania, Minucci, Saverio, Mercurio, Ciro
Published in ChemMedChem (01.04.2012)
Published in ChemMedChem (01.04.2012)
Get full text
Journal Article
A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance
Santoro, Fabio, Botrugno, Oronza A., Dal Zuffo, Roberto, Pallavicini, Isabella, Matthews, Geoffrey M., Cluse, Leonie, Barozzi, Iros, Senese, Silvia, Fornasari, Lorenzo, Moretti, Simona, Altucci, Lucia, Pelicci, Pier Giuseppe, Chiocca, Susanna, Johnstone, Ricky W., Minucci, Saverio
Published in Blood (25.04.2013)
Published in Blood (25.04.2013)
Get full text
Journal Article
Discovery, Synthesis, and Pharmacological Evaluation of Spiropiperidine Hydroxamic Acid Based Derivatives as Structurally Novel Histone Deacetylase (HDAC) Inhibitors
Varasi, Mario, Thaler, Florian, Abate, Agnese, Bigogno, Chiara, Boggio, Roberto, Carenzi, Giacomo, Cataudella, Tiziana, Dal Zuffo, Roberto, Fulco, Maria Carmela, Rozio, Marco Giulio, Mai, Antonello, Dondio, Giulio, Minucci, Saverio, Mercurio, Ciro
Published in Journal of medicinal chemistry (28.04.2011)
Published in Journal of medicinal chemistry (28.04.2011)
Get full text
Journal Article
Chiral Resolution and Pharmacological Characterization of the Enantiomers of the Hsp90 Inhibitor 2‐Amino‐7‐[4‐fluoro‐2‐(3‐pyridyl)phenyl]‐4‐methyl‐7,8‐dihydro‐6 H ‐quinazolin‐5‐one Oxime
Amici, Raffaella, Bigogno, Chiara, Boggio, Roberto, Colombo, Andrea, Courtney, Stephen M., Dal Zuffo, Roberto, Dondio, Giulio, Fusar, Fulvia, Gagliardi, Stefania, Minucci, Saverio, Molteni, Marco, Montalbetti, Christian A. G. N., Mortoni, Annalisa, Varasi, Mario, Vultaggio, Stefania, Mercurio, Ciro
Published in ChemMedChem (01.07.2014)
Published in ChemMedChem (01.07.2014)
Get full text
Journal Article