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Laux-Biehlmann, Alexis, d’Hooghe, Thomas, Zollner, Thomas M
Published in Trends in pharmacological sciences (Regular ed.) (01.05.2015)
Published in Trends in pharmacological sciences (Regular ed.) (01.05.2015)
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Discovery and Characterization of the Potent and Selective P2X4 Inhibitor N‑[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and Structure-Guided Amelioration of Its CYP3A4 Induction Profile
Werner, Stefan, Mesch, Stefanie, Hillig, Roman C, ter Laak, Antonius, Klint, Julie, Neagoe, Ioana, Laux-Biehlmann, Alexis, Dahllöf, Henrik, Bräuer, Nico, Puetter, Vera, Nubbemeyer, Reinhard, Schulz, Simone, Bairlein, Michaela, Zollner, Thomas M, Steinmeyer, Andreas
Published in Journal of medicinal chemistry (26.12.2019)
Published in Journal of medicinal chemistry (26.12.2019)
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Eliapixant is a selective P2X3 receptor antagonist for the treatment of disorders associated with hypersensitive nerve fibers
Davenport, Adam J., Neagoe, Ioana, Bräuer, Nico, Koch, Markus, Rotgeri, Andrea, Nagel, Jens, Laux-Biehlmann, Alexis, Machet, Frederic, Coelho, Anne-Marie, Boyce, Susan, Carty, Nikisha, Gemkow, Mark J., Hess, Stephen D., Zollner, Thomas M., Fischer, Oliver M.
Published in Scientific reports (06.10.2021)
Published in Scientific reports (06.10.2021)
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Mass cytometry analysis reveals a distinct immune environment in peritoneal fluid in endometriosis: a characterisation study
Guo, Manman, Bafligil, Cemsel, Tapmeier, Thomas, Hubbard, Carol, Manek, Sanjiv, Shang, Catherine, Martinez, Fernando O, Schmidt, Nicole, Obendorf, Maik, Hess-Stumpp, Holger, Zollner, Thomas M, Kennedy, Stephen, Becker, Christian M, Zondervan, Krina T, Cribbs, Adam P, Oppermann, Udo
Published in BMC medicine (07.01.2020)
Published in BMC medicine (07.01.2020)
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Discovery of BAY-390, a Selective CNS Penetrant Chemical Probe as Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonist
Mesch, Stefanie, Walter, Daryl, Laux-Biehlmann, Alexis, Basting, Daniel, Flanagan, Stuart, Miyatake Ondozabal, Hideki, Bäurle, Stefan, Pearson, Christopher, Jenkins, James, Elves, Philip, Hess, Stephen, Coelho, Anne-Marie, Rotgeri, Andrea, Bothe, Ulrich, Nawaz, Schanila, Zollner, Thomas M., Steinmeyer, Andreas
Published in Journal of medicinal chemistry (26.01.2023)
Published in Journal of medicinal chemistry (26.01.2023)
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Discovery of IRAK4 Inhibitors BAY1834845 (Zabedosertib) and BAY1830839
Bothe, Ulrich, Günther, Judith, Nubbemeyer, Reinhard, Siebeneicher, Holger, Ring, Sven, Bömer, Ulf, Peters, Michaele, Rausch, Alexandra, Denner, Karsten, Himmel, Herbert, Sutter, Andreas, Terebesi, Ildiko, Lange, Martin, Wengner, Antje M., Guimond, Nicolas, Thaler, Tobias, Platzek, Johannes, Eberspächer, Uwe, Schäfer, Martina, Steuber, Holger, Zollner, Thomas M., Steinmeyer, Andreas, Schmidt, Nicole
Published in Journal of medicinal chemistry (25.01.2024)
Published in Journal of medicinal chemistry (25.01.2024)
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Anxiety-related behaviors without observation of generalized pain in a mouse model of endometriosis
Nunez-Badinez, Paulina, Laux-Biehlmann, Alexis, Hayward, Michael D, Buiakova, Olesia, Zollner, Thomas M, Nagel, Jens
Published in Frontiers in behavioral neuroscience (09.02.2023)
Published in Frontiers in behavioral neuroscience (09.02.2023)
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Identification of a Benzimidazolecarboxylic Acid Derivative (BAY 1316957) as a Potent and Selective Human Prostaglandin E2 Receptor Subtype 4 (hEP4-R) Antagonist for the Treatment of Endometriosis
Bäurle, Stefan, Nagel, Jens, Peters, Olaf, Bräuer, Nico, ter Laak, Antonius, Preusse, Cornelia, Rottmann, Antje, Heldmann, Dieter, Bothe, Ulrich, Blume, Thorsten, Zorn, Ludwig, Walter, Daryl, Zollner, Thomas M, Steinmeyer, Andreas, Langer, Gernot
Published in Journal of medicinal chemistry (14.03.2019)
Published in Journal of medicinal chemistry (14.03.2019)
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Preclinical models of endometriosis and interstitial cystitis/bladder pain syndrome: an Innovative Medicines Initiative-PainCare initiative to improve their value for translational research in pelvic pain
Nunez-Badinez, Paulina, De Leo, Bianca, Laux-Biehlmann, Alexis, Hoffmann, Anja, Zollner, Thomas M., Saunders, Philippa T.K., Simitsidellis, Ioannis, Charrua, Ana, Cruz, Francisco, Gomez, Raul, Tejada, Miguel Angel, McMahon, Stephen B., Lo Re, Laure, Barthas, Florent, Vincent, Katy, Birch, Judy, Meijlink, Jane, Hummelshoj, Lone, Sweeney, Patrick J., Armstrong, J. Douglas, Treede, Rolf-Detlef, Nagel, Jens
Published in Pain (Amsterdam) (01.09.2021)
Published in Pain (Amsterdam) (01.09.2021)
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Discovery of the potent non-steroidal glucocorticoid receptor modulator BAY 1003803 as clinical candidate
Berger, Markus, May, Ekkehard, Rehwinkel, Hartmut, Schäcke, Heike, Neuhaus, Roland, Rottmann, Antje, Zollner, Thomas M., Jaroch, Stefan
Published in Bioorganic & medicinal chemistry letters (15.08.2020)
Published in Bioorganic & medicinal chemistry letters (15.08.2020)
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Discovery and Characterization of BAY 1214784, an Orally Available Spiroindoline Derivative Acting as a Potent and Selective Antagonist of the Human Gonadotropin-Releasing Hormone Receptor as Proven in a First-In-Human Study in Postmenopausal Women
Panknin, Olaf, Wagenfeld, Andrea, Bone, Wilhelm, Bender, Eckhard, Nowak-Reppel, Katrin, Fernández-Montalván, Amaury E, Nubbemeyer, Reinhard, Bäurle, Stefan, Ring, Sven, Schmees, Norbert, Prien, Olaf, Schäfer, Martina, Friedrich, Christian, Zollner, Thomas M, Steinmeyer, Andreas, Mueller, Thomas, Langer, Gernot
Published in Journal of medicinal chemistry (22.10.2020)
Published in Journal of medicinal chemistry (22.10.2020)
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Neuropeptide S receptor 1 is a nonhormonal treatment target in endometriosis
Tapmeier, Thomas T, Rahmioglu, Nilufer, Lin, Jianghai, De Leo, Bianca, Obendorf, Maik, Raveendran, Muthuswamy, Fischer, Oliver M, Bafligil, Cemsel, Guo, Manman, Harris, Ronald Alan, Hess-Stumpp, Holger, Laux-Biehlmann, Alexis, Lowy, Ernesto, Lunter, Gerton, Malzahn, Jessica, Martin, Nicholas G, Martinez, Fernando O, Manek, Sanjiv, Mesch, Stefanie, Montgomery, Grant W, Morris, Andrew P, Nagel, Jens, Simmons, Heather A, Brocklebank, Denise, Shang, Catherine, Treloar, Susan, Wells, Graham, Becker, Christian M, Oppermann, Udo, Zollner, Thomas M, Kennedy, Stephen H, Kemnitz, Joseph W, Rogers, Jeffrey, Zondervan, Krina T
Published in Science translational medicine (25.08.2021)
Published in Science translational medicine (25.08.2021)
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Discovery and optimization of pyridyl-cycloalkyl-carboxylic acids as inhibitors of microsomal prostaglandin E synthase-1 for the treatment of endometriosis
Koppitz, Marcus, Bräuer, Nico, Ter Laak, Antonius, Irlbacher, Horst, Rotgeri, Andrea, Coelho, Anne-Marie, Walter, Daryl, Steinmeyer, Andreas, Zollner, Thomas M., Peters, Michaele, Nagel, Jens
Published in Bioorganic & medicinal chemistry letters (15.09.2019)
Published in Bioorganic & medicinal chemistry letters (15.09.2019)
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Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions
Thézénas, Marie-Laëtitia, De Leo, Bianca, Laux-Biehlmann, Alexis, Bafligil, Cemsel, Elger, Bernd, Tapmeier, Thomas, Morten, Karl, Rahmioglu, Nilufer, Dakin, Stephanie G., Charles, Philip, Martinez, Fernando Estrada, Steers, Graham, Fischer, Oliver M., Mueller, Joerg, Hess-Stumpp, Holger, Steinmeyer, Andreas, Manek, Sanjiv, Zondervan, Krina T., Kennedy, Stephen, Becker, Christian M., Shang, Catherine, Zollner, Thomas M., Kessler, Benedikt M., Oppermann, Udo
Published in Scientific reports (30.01.2020)
Published in Scientific reports (30.01.2020)
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Induction of overt menstruation in intact mice
Rudolph, Marion, Döcke, Wolf-Dietrich, Müller, Andrea, Menning, Astrid, Röse, Lars, Zollner, Thomas Matthias, Gashaw, Isabella
Published in PloS one (07.03.2012)
Published in PloS one (07.03.2012)
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Mast cells in endometriosis: guilty or innocent bystanders?
Kirchhoff, Dennis, Kaulfuss, Stefan, Fuhrmann, Ulrike, Maurer, Marcus, Zollner, Thomas M
Published in Expert opinion on therapeutic targets (01.03.2012)
Published in Expert opinion on therapeutic targets (01.03.2012)
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